Cold-induced metabolic flexibility explains ethnic disparities among individuals with obesity and insulin resistance [0.03%]
冷引起的代谢灵活性解释了肥胖和胰岛素抵抗个体之间的种族差异
Lijuan Sun,Hui Jen Goh,Xinyan Bi et al.
Lijuan Sun et al.
Background: Cold-induced thermogenesis (CIT) mediated by brown adipose tissue (BAT) and skeletal muscle holds therapeutic utility for obesity, but relative tissue contribution to CIT-driven metabolic flexibility (MetF) an...
Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight [0.03%]
癫痫相关肥胖和超重的遗传风险、抗惊厥药物和生活方式因素
Jiaqi Wang,Zihua He,Sisi Shen et al.
Jiaqi Wang et al.
Background: Obesity is common among people with epilepsy and is influenced by genetic susceptibility, lifestyle behaviours, and antiseizure medications (ASMs). How ASMs and lifestyle factors interact with genetic risk for...
A time bridge for obesity care: protein monitoring adds a timing layer to the EASO pathway while preserving the Lancet Commission definition [0.03%]
肥胖症治疗的时间桥梁：蛋白质监测在EASO路径中添加了时间层，同时保留了柳叶刀委员会的定义
Enzo Nisoli,Michele O Carruba,Alessandra Valerio
Enzo Nisoli
The European Association for the Study of Obesity (EASO) frames obesity care around staged, target-driven decisions. The Lancet Diabetes & Endocrinology Commission provides a disease definition-clinical obesity requires objective dysfunctio...
A qualitative study exploring key informant perspectives on obesity prevention efforts in France [0.03%]
一项定性研究：探究法国肥胖预防工作的关键信息提供者的观点
Nour M Hammad,Isabelle Romieu,Sébastien Czernichow et al.
Nour M Hammad et al.
Objective: To explore key informants' perspectives on how France has maintained a lower obesity prevalence than other high-income countries and the challenges that may limit France's current response to the obesity epidem...
An experimental investigation of the stigmatization of weight loss and regain from GLP-1 receptor agonist use and cessation [0.03%]
GLP-1受体激动剂的减重和复胖的污名化现象的实验调查
Erin C Standen,Sean M Phelan,A Janet Tomiyama
Erin C Standen
Background/objectives: Glucagon-like peptide-1 receptor agonist medications (GLP-1s) are effective for weight loss, but when people discontinue them, they tend to regain weight. The present work sought to examine the stig...
Central amygdala neuropeptide Y neurons drive hedonic ingestive behaviour independent of energy homeostasis [0.03%]
中枢杏仁体神经肽Y神经元可驱动独立于能量平衡的愉悦摄食行为
Neda Rafiei,Caitlin S Mitchell,Philip Jean-Richard-Dit-Bressel et al.
Neda Rafiei et al.
Background/objectives: Neuropeptide Y (NPY), a key orexigenic neurotransmitter, is widely expressed in the central nervous system, including in a distinct subpopulation of neurons within the central nucleus of the amygdal...
γδ T cell exhaustion is associated with obesity in individuals with type 2 diabetes [0.03%]
肥胖伴2型糖尿病患者的γδ T细胞衰竭现象
Ke Li,Guichao Liu,Guojun Zhang et al.
Ke Li et al.
Obesity is a major factor driving immune exhaustion in adaptive immune cells, yet its effect on the exhaustion of peripheral circulating innate γδ T cells in individuals with type 2 diabetes (T2D) remains poorly understood. In this study,...
Mediators and moderators of successful population-level weight management in primary care: results from the PATHWEIGH cluster-randomized pragmatic trial [0.03%]
成功的一线医疗人群体重管理的中介和调节因素——一项PATHWEIGH群组随机实用试验的结果
Leigh Perreault,Carlos Rodriguez,Peter C Smith et al.
Leigh Perreault et al.
PATHWEIGH is the first intervention scaled to 274,182 patients to mitigate population weight gain. In a stepped-wedge cluster-randomized pragmatic trial in Colorado, USA, 56 primary care clinics were randomly assigned to three clusters with...
Obesity prevalence: comparison of traditional and new classification approaches in a Swiss population-based study (2005-2024) [0.03%]
肥胖流行率：在一项基于瑞士人口的研究中比较传统和新的分类方法（2005-2024）
Mayssam Nehme,Celine Mettraux,Claire Chevalier et al.
Mayssam Nehme et al.
Background/objective: Obesity has traditionally been defined using body mass index (BMI), but this may overlook central adiposity and related metabolic risks. In 2025, new guidelines recommended adding anthropometric meas...
The relationship between weight, eating behaviours and mental health over time in the YOUTH longitudinal cohort study [0.03%]
基于YOUTH纵向队列研究探讨体重、饮食行为和心理健康之间的关系变化趋势
Megan Whatnall,Therese Fozard,Katerina Z Kolokotroni et al.
Megan Whatnall et al.
Background: Weight, eating behaviours and mental health have a complex interrelationship that is not fully understood. This study aimed to investigate the relationships between weight, eating behaviours and mental health ...