Dual amylin and calcitonin receptor agonists as multifaceted disease-modifying osteoarthritis drugs [0.03%]
一种双胰岛素和降钙素受体激动剂类风湿关节炎多功能改病药物
Khaled Elhady Mohamed,Anna Thorsø Larsen,Christian S Thudium et al.
Khaled Elhady Mohamed et al.
Obesity is a powerful driver in the development and progression of osteoarthritis (OA), contributing to increased mechanical load and metabolic stress, making it a valuable target for treatment. Weight loss is a cornerstone of OA management...
Triglyceride-glucose index trajectories and the incident risk of type 2 diabetes mellitus in Chinese adults with normal weight: the China-PAR project [0.03%]
中国正常体重成人胰岛素抵抗轨迹与2型糖尿病风险：中国心脏研究项目数据
Yuying Wu,Yang Zhao,Yanyan Zhang et al.
Yuying Wu et al.
Objective: The association between the longitudinal trajectory changes of triglyceride-glucose (TyG) index and type 2 diabetes mellitus (T2DM) is still unclear among the population with normal weight; hence, we aimed to i...
A mental model of obesity: comparing expert and public perceptions in Ireland, the UK, and the US [0.03%]
肥胖的认知模型：比较爱乐、英国和美国专家与民众的感知差异
Deirdre A Robertson,Ylva Andersson,Ciarán Lavin et al.
Deirdre A Robertson et al.
Objective: Despite scientific evidence on the environmental causes of obesity, policies that target these causes frequently face public opposition. This study investigates the mental model that the public hold about obesi...
Exercise reprograms the gut microbiota to enhance metabolic outcomes after bariatric surgery: a translational, cross-species study [0.03%]
运动调节肠道菌群以增强肥胖手术后的代谢结局：一项转化医学跨物种研究
Alisson Padilha de Lima,Juliana Bueno de Novais,Adriane Elisabete Costa Antunes et al.
Alisson Padilha de Lima et al.
Background/objectives: Exercise training has been associated with metabolic improvements in bariatric patients beyond weight and fat loss, potentially involving modulation of the gut microbiota. We investigated whether ex...
Long-term effect of sweeteners and sweetness enhancers on gene expression markers of adipose tissue function, adipocyte morphology, and metabolic health: a SWEET substudy [0.03%]
代糖和甜味增强剂对基因表达标志物、脂肪细胞形态和代谢健康长期影响的SWEET亚研究：一项关于胰岛素抵抗个体的研究
Michelle D Pang,Jacco J A J Bastings,Johan W E Jocken et al.
Michelle D Pang et al.
Background/objectives: We investigated the effects of sweeteners and sweetness enhancers (S&SEs) in replacement of sugar on gene expression markers of adipose tissue (AT) function, adipocyte morphology, and metabolic heal...
Exercise attenuates obesity-related cognitive and sleep-circadian dysfunctions by attenuating neuroinflammation via JAK/STAT in sex and age specific manner [0.03%]
运动通过性别和年龄特异性的JAK/STAT依赖性神经炎症作用减轻肥胖相关认知功能障碍和睡眠-生物钟节律异常
Archana Yadav,Morgan Barkley,John C Watson et al.
Archana Yadav et al.
Background: Obesity including genetic obesity accelerates age-related cognitive decline and disrupts circadian regulation, increasing the risk of neurodegenerative disorders. These effects are mediated in part by metaboli...
Dietary intake of polybrominated diphenyl ethers (PBDEs) and the risk of obesity in the French E3N cohort [0.03%]
法国E3N队列人群饮食多溴二苯醚(PBDEs)暴露与肥胖风险关系研究
Xuan Ren,Pauline Frenoy,Fanny Artaud et al.
Xuan Ren et al.
Background: Polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants, with the primary exposure pathway for the general population being the consumption of contaminated food. Human exposure to PBDEs is sus...
Altered hypothalamic functional connectivity in adolescents with severe obesity [0.03%]
肥胖青少年下丘脑功能连接的改变
Allison L B Shapiro,Meghan E Pauley,Jaime M Moore et al.
Allison L B Shapiro et al.
Background/objectives: Neurobiological frameworks of obesity in youth have focused largely on non-homeostatic systems (reward, salience, executive control), while the homeostatic system-particularly the hypothalamus-is co...
Associations of body composition and resting metabolic rate with homeostatic and hedonic components of appetite [0.03%]
身体组成和基础代谢率与摄食的稳态因素和快感寻求因素的关系
Arwa Alruwaili,Hannah Trotman,Laure Haenebalcke et al.
Arwa Alruwaili et al.
Background: While fat-free mass (FFM), fat mass (FM), and resting metabolic rate (RMR) influence energy intake, their specific roles as homoeostatic and hedonic drivers of eating-and factors moderating these relationships...
Artificial intelligence in cardio-kidney-metabolic care: Transforming integrated disease management through data-informed innovation [0.03%]
人工智能在心血管-肾脏-代谢性疾病护理中的应用：通过数据驱动的创新转化综合疾病管理
Clipper F Young,Janice MacLeod
Clipper F Young
Artificial intelligence (AI) is rapidly transforming the landscape of chronic medical conditions, such as cardio-kidney-metabolic (CKM) issues linked to type 2 diabetes and obesity. It creates new opportunities to shift from reactive to pro...