Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer [0.03%]
肺癌相关巨噬细胞表型与长链非编码RNA的关系研究
Yvessa Verheyden,Sonia Cinque,Daliya Kancheva et al.
Yvessa Verheyden et al.
Tumour-associated macrophages (TAMs) are central players in the tumour microenvironment, driving cancer progression and modulating immune responses. Renowned for their ability to rapidly adapt to environmental changes, TAMs can adopt a wide...
STAMBP drives colorectal cancer progression via CXCR4 deubiquitination and bone marrow-derived suppressor cell recruitment [0.03%]
STAMBP通过CXCR4去泛素化和募集骨髓源性抑制细胞促进结直肠癌进展
Yang Yang,Song Zhao,Feng Jing et al.
Yang Yang et al.
Colorectal cancer (CRC) is one of the three leading causes of tumor-related mortality worldwide. The recruitment of bone marrow-derived suppressor cells (MDSCs) is a key mechanism by which tumors evade immune surveillance, as these cells in...
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections [0.03%]
SARS-CoV-2、HBV、HIV和HSV感染中miRNA介导的免疫调节机制分析
Suleyman Arziman,Sevim Aydemir,Vildan Bozok
Suleyman Arziman
Eukaryotic cells regulate gene expression through multiple checkpoints, including post-transcriptional mechanisms mediated by microRNAs (miRNAs). These small non-coding RNAs inhibit translation by binding to target mRNAs, often within a com...
Maialen Sebastian-delaCruz,Ane Olazagoitia-Garmendia,Izei Pascual-Gonzalez et al.
Maialen Sebastian-delaCruz et al.
N6-methyladenosine (m6A) RNA modifications and reovirus infections have recently been implicated in the development of celiac disease. While viral infections are known to alter the RNA modification machinery of the host, their interplay in ...
Recruitment of CCR5+ inflammatory monocytes in pulmonary tissue contributes to acute lung injury [0.03%]
肺组织中CCR5+炎症单核细胞的募集在急性肺损伤中的作用
Dongdong Wei,Xuebiao Li,Guocong Xu et al.
Dongdong Wei et al.
Acute lung injury (ALI) is a common serious complication following deep hypothermic circulatory arrest (DHCA). Monocytes and macrophages play crucial roles in producing inflammatory mediators and regulating innate and adaptive immunity. In ...
Radiotherapy combined with anti-PD-1 immunotherapy promotes ferroptosis-driven control of hepatocellular carcinoma [0.03%]
放疗联合抗PD-1免疫治疗可促进铁死亡介导的肝细胞癌控制作用
Ting Dou,Xianggao Zhu,Hong Li et al.
Ting Dou et al.
Combination of radiotherapy (RT) and anti-PD-1 immunotherapy (IO) has shown significant efficacy in treating hepatocellular carcinoma (HCC). Nevertheless, yet the underlying mechanisms remain incompletely understood. A Hepa1-6 mouse HCC mod...
Structural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein [0.03%]
TGM-2（一种免疫调节寄生虫蛋白）的结构和功能分析
Emmaculate Yaah Ntang,Kyle T Cunningham,Shashi P Singh et al.
Emmaculate Yaah Ntang et al.
The extraordinary prevalence of helminths is attributable to secretion of molecules that manipulate the host immune system, facilitating their survival. Among the secretory products of the murine intestinal helminth Heligmosomoides polygyru...
Molecular analysis and immunological characterization of a founder mutation causing ARPC1B deficiency [0.03%]
ARPC1B缺陷型创始人突变的分子分析及免疫学特征研究
Megan M Dobrose,Meltem Ece Kars,Jareb J Perez-Caraballo et al.
Megan M Dobrose et al.
Actin-Related Protein Complex 1B (ARPC1B) is a subunit of the ARP2/3 complex that is predominately expressed in hematopoietic cells and is involved in the regulation of actin polymerization. ARPC1B deficiency leads to combined immunodeficie...
Spatiotemporal transcriptomic insights into ferroptosis and TFRC-linked immune interactions in ischemia-reperfusion acute kidney injury [0.03%]
缺血再灌注急性肾损伤中铁死亡和TFRC相关免疫互作的时空转录组学见解
Yulin Wang,Cheng Zhu,Shiqi Lv et al.
Yulin Wang et al.
Acute kidney injury (AKI) is a common and critical clinical condition with complex pathogenesis and limited early intervention options. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a pivotal role in ...
Jianghong Zhong,Zhongheng Chen,Hangqi Yue et al.
Jianghong Zhong et al.
Genetic variants of NCF1 that impair the production of reactive oxygen species (ROS) are associated with lupus in humans; however, the underlying mechanism of immune dysregulation remains unclear. To clarify this mechanism, the study tested...