PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury [0.03%]
PDK4驱动的乳酸积累促进LPCAT2乳酰化以加重脓毒症诱导的急性肺损伤
Yifan Deng,Yuetan Qiu,Xiang Li et al.
Yifan Deng et al.
Elevated glycolysis in lung tissue is a hallmark of sepsis-induced acute lung injury (SI-ALI), yet the role of glycolytic reprogramming and lactate-derived protein modifications in damaging epithelial cells remains poorly understood. In thi...
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth [0.03%]
O-GlcNAc酰化调控UGDH活性及重塑细胞外基质以促进肿瘤生长
Bingyi Lin,Junjie Zhou,Didi Geng et al.
Bingyi Lin et al.
The tumor microenvironment is an immunosuppressive niche that contributes to tumor growth by downregulating immune cell functions or restraining immune cell infiltration. The underlying mechanisms are not still poorly understood. Here, we d...
Caspase-8 expression and its Src dependent phosphorylation on Tyrosine 380 triggers NRF2 signaling activation in glioblastoma [0.03%]
胶质母细胞瘤中胱天蛋白酶-8的表达及其Src依赖性的酪氨酸380磷酸化触发NRF2信号活化
Claudia Cirotti,Claudia Di Girolamo,Irene Taddei et al.
Claudia Cirotti et al.
Caspase-8 expression is upregulated in many tumors where, despite its canonical apoptotic pathway, it sustains cancer progression promoting cell migration, NF-kB activation and inflammation. Here, we provide the first evidence for a novel r...
K11- and K29-ubiquitination-mediated nuclear translocation of glycolytic enzyme aldolase A promotes pancreatic cancer progression by NF-κB activation [0.03%]
丙酮酸激酶M2通过去泛素化酶USP21介导的K48去泛素化稳定在结直肠癌中促进肿瘤生长和转移
Siru Zhou,Yulin Li,Chao Wang et al.
Siru Zhou et al.
The function of cytosolic aldolase A (ALDOA) in glycolysis is well recognized. However, the cytosol-to-nucleus redistribution of ALDOA and its nuclear function is poorly understood. Here, we uncover inflammatory factor-stimulated nuclear fu...
Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex [0.03%]
小鼠新皮层神经元MCT2通过乳酸促进发育中的血管生成
Daehoon Lee,Anika Wu,Lingling Yao et al.
Daehoon Lee et al.
Neural activity drives blood vessel (BV) formation and energy substrate delivery in the developing brain to meet rising metabolic demands; however, the underlying mechanisms remain poorly understood. In this study, we exposed neonatal mice ...
Christophe Arnoult,Laura D Attardi,Kerem Batsheva et al.
Christophe Arnoult et al.
AMPK-activated BAP1 regulates pVHL stability and tumor-suppressive functions [0.03%]
活化型BAP1调节pVHL稳定性及其抑癌功能
Mei Li,Lei Huang,Jiayi Chen et al.
Mei Li et al.
The von Hippel-Lindau (VHL) protein (pVHL) functions as a potent tumor suppressor by mediating the degradation or inactivation of various substrates, including HIFα and Akt. However, pVHL is frequently downregulated in numerous cancers har...
Epithelial MST1 deficiency promotes pyroptosis and aggravates inflammatory bowel disease via the YAP/p73 signaling pathway [0.03%]
MST1上皮缺陷通过YAP/p73信号途径促进焦亡并加重炎症性肠病
Jiali Lu,Fei Li,Hailin Wang et al.
Jiali Lu et al.
The Hippo pathway has been implicated in the onset and pathogenesis of inflammatory bowel disease (IBD), with Mammalian STE20-like kinase 1 (MST1), a core kinase in this pathway, playing significant roles in inflammation and immune regulati...
USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ [0.03%]
USP2通过稳定PPARγ促进与代谢紊乱相关的肝脂肪变性疾病进展
Hao Luo,Chujiao Zhu,Yingying Wang et al.
Hao Luo et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide, yet the molecular mechanisms underlying its pathogenesis are not fully understood. Here, we identify the deubiquitinatin...
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy [0.03%]
糖尿病肾病中铁依赖性细胞焦亡的表观遗传调控机制研究：天冬氨酸-tRNA合成酶1介导组蛋白H3K18乳酰化促进STAT1信号异常激活
Jia Hong,Hongjiao Xu,Lang Yu et al.
Jia Hong et al.
Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide. Recent studies have revealed that lactate-mediated histone lactylation, which functions as a novel epigenetic modification, is involved in the occurrence a...