NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression [0.03%]
Keng Ye,Siyi Lin,Caiming Chen et al.
Keng Ye et al.
The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) remains a major clinical challenge. It is primarily triggered by renal tubular epithelial cell (RTEC) death that leads to persistent sterile inflammation, maladapt...
Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling [0.03%]
Hanqing Zhu,Ping Yuan,Xiangyang Wu et al.
Hanqing Zhu et al.
Dysfunction of vascular endothelial cells is recognized as a critical driver in pulmonary vascular remodeling of pulmonary hypertension (PH). Although interleukin-6 (IL-6) has been firmly established as an indispensable factor leading to pu...
Correction: The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope [0.03%]
关于论文“肿瘤抑制蛋白PML调控HIV-1包膜诱导的细胞凋亡”的勘误通知
J-L Perfettini,R Nardacci,C Séror et al.
J-L Perfettini et al.
Published Erratum
Cell death and differentiation. 2026 Apr 24. DOI:10.1038/s41418-026-01745-2 2026
FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis [0.03%]
FAAH通过抑制铁死亡促进肺腺癌进展的正反馈调节作用
Xinyi He,Cheng Tang,Tongtong Jiang et al.
Xinyi He et al.
Ferroptosis represents an iron-dependent form of cell death characterized by accumulation of lipid peroxides. However, it is largely elusive how authentic lipid metabolites contribute to ferroptosis, and whether this is dysregulated in mali...
Role of the cross-regulation between Wnt pathway activation and androgen receptor signaling in prostate cancer treatment resistance [0.03%]
Wnt信号激活与雄激素受体信号之间的交叉调节在前列腺癌治疗抵抗中的作用
Nicolas Anselmino,Pablo Sanchis,Juan Bizzotto et al.
Nicolas Anselmino et al.
Prostate cancer (PCa) is a biologically heterogeneous disease that frequently progresses to castration-resistant prostate cancer (CRPC), a challenging clinical stage. The underlying mechanisms driving CRPC progression and resistance to andr...
Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8+T cells against colorectal cancer [0.03%]
靶向CAF来源的PCSK6抑制PD-L1重新分布并恢复CD8+t细胞对结直肠癌的作用
Qianming Du,Yuxiang Fei,Tao Li et al.
Qianming Du et al.
Carcinoma-associated fibroblasts (CAFs) are core components of the tumor microenvironment, which contribute to tumor initiation and progression through mediating immune suppression. In this study, eight activated CAF subpopulations were ide...
Diva Sinha,Sonia S Shah,Sharad Kumar
Diva Sinha
Ubiquitination is a versatile post-translational modification that regulates protein stability, localisation and signalling. By modifying a wide range of substrates, ubiquitination controls key physiological processes, including inflammator...
Editorial Expression of Concern: The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis [0.03%]
表达关注声明：腺嘌呤核苷酸转运蛋白1作为第2型谷氨酰胺转胺酶底物的作用：其对线粒体凋亡的意涵
W Malorni,M G Farrace,P Matarrese et al.
W Malorni et al.
Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses [0.03%]
Shoc2信号支架通过抑制mTORC1介导的干扰素反应调节淋巴管生成
Patricia Wilson,Vishakha Vishwakarma,Rebecca Norcross et al.
Patricia Wilson et al.
An interplay of growth factors and signaling pathways governs the development and maintenance of lymphatic vasculature, ensuring proper fluid homeostasis and immune function. Disruption of these regulatory mechanisms can lead to congenital ...
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production [0.03%]
RIPK3依次募集MLKL和RIPK1诱导PANoptosis及细胞因子产生
Yu Yang,Yue Wang,Yang Wang et al.
Yu Yang et al.
Receptor-interacting protein kinase 3 (RIPK3) has emerged as a central player in necroptosis and apoptosis activation in specific scenarios, concurrently modulating inflammatory responses. Here, we reveal that direct activation of RIPK3 con...