Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy-induced peripheral neurotoxicity [0.03%]
蛋白酶体抑制剂在化疗诱发的外周神经毒性中的共通和特异性分子机制
Federico Iseppon,Alessio Malacrida,Alessia Chiorazzi et al.
Federico Iseppon et al.
Background and purpose: Proteasome inhibitors have been approved for treatment of multiple myeloma but induce significant chemotherapy-related peripheral neurotoxicity in up to one third of patients. Crucial information a...
Haemostatic changes and bleeding with anti-IL-6 directed therapy in autoimmune diseases [0.03%]
抗IL-6治疗自身免疫性疾病过程中的止血变化和出血事件
Charlotte D C C van der Heijden,Loes C Oskam,Lenny van Bon et al.
Charlotte D C C van der Heijden et al.
Anti-IL-6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulato...
Neutrophil extracellular traps drive tubulointerstitial fibrosis via the coiled-coil domain-containing protein 25 (CCDC25)-Yes-associated protein 1 (YAP1) axis-mediated autophagy regulation [0.03%]
中性粒细胞胞外陷阱通过CCDC25-YAP1轴介导的自噬调节驱动肾间质纤维化
Xinhui Hu,Weijie Ni,Haifei Liu et al.
Xinhui Hu et al.
Background and purpose: Tubulointerstitial fibrosis (TIF) is a pathological hallmark of chronic kidney disease (CKD) without effective therapy. Neutrophil extracellular traps (NETs) are complex web-like structures release...
Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology [0.03%]
哺乳动物伤害性热感觉的神经元和离子通道机制：感觉生理学和药理学的一个谜题
Gábor Pethő,Peter W Reeh
Gábor Pethő
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat-sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the p...
Fn14 signalling participates in pristane-induced murine lupus through exacerbating oxidative stress [0.03%]
FN14信号通过加剧氧化应激参与石腊油诱导的小鼠狼疮发病过程
Zhu Yan,Rongfang Feng,Mai Luo et al.
Zhu Yan et al.
Background and purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor-inducible 14 (Fn14) has been implicated in tissue in...
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes [0.03%]
肠促胰素类似物对肥胖和糖尿病患者脂质及脂蛋白代谢的影响
Andrea Baragetti,Giuseppe Danilo Norata
Andrea Baragetti
Incretin-based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in ...
Identification of drug repurposing candidates for the treatment of polycystic kidney disease [0.03%]
用于治疗多囊肾病的药物再定位候选物的识别
Alina Meyer,Paraskevi Sotiropoulou,Koussai Bouker et al.
Alina Meyer et al.
Background and purpose: Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective tre...
Susan Wonnacott,Gary J Stephens,Trevor Sharp
Susan Wonnacott
Increasing interest in psychedelic and related drugs as potential therapies for a wide spectrum of difficult-to-treat conditions, that extend beyond neuropsychiatric disorders, provided the impetus for this themed issue. This collection of ...
Endothelium- and epithelium-derived novel endogenous catecholamines as modulators of the autonomic nervous system [0.03%]
新型内源性儿茶酚胺调节自主神经系统的机制研究进展：来自血管和上皮细胞的新证据
Mariana G de Oliveira,Edson Antunes,Fabiola Zakia Monica et al.
Mariana G de Oliveira et al.
Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Phy...
Development of a long-acting relaxin for the treatment of pulmonary hypertension [0.03%]
长效Relaxin治疗肺动脉高压的研究发展
John Diener,Hitesh Soni,Jason Booe et al.
John Diener et al.
Background and purpose: Relaxin is a naturally occurring peptide hormone with significant cardiovascular effects, particularly during the adaptation to pregnancy. A short-acting peptide therapeutic previously demonstrated...