Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin-dependent protein kinase IIδ in a murine model of acute doxorubicin-related cardiotoxicity [0.03%]
抑制晚钠电流可预防阿霉素诱发急性心脏毒性小鼠模型中钙/钙调素依赖型蛋白激酶Ⅱδ的病理激活
Anna-Lena Feder,Anna-Maria Pfützenreuter,Lea Maria Funke et al.
Anna-Lena Feder et al.
Background and purpose: Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin-induced toxic cardiomyopathy (DICM) ...
Subregion-specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment [0.03%]
背海马亚区特异性神经周围网重塑介导慢性应激易感性及抗压性的表型转换：盐酸文拉法辛的作用机制
Paola Brivio,Arianna Palumbo,Maria Teresa Gallo et al.
Paola Brivio et al.
Background and purpose: Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core p...
Tyrosine-protein phosphatase non-receptor type 2 deficiency in macrophages diminishes the anti-inflammatory and cardioprotective effects of gabapentin after myocardial infarction [0.03%]
酪氨酸蛋白磷酸酶非受体2型缺乏通过削弱加巴喷丁的抗炎和心脏保护作用限制心肌梗死后的巨噬细胞极化
Zhenjun Li,Guo Dong,Gaojun Shan et al.
Zhenjun Li et al.
Background and purpose: Our previous study has highlighted the anti-inflammatory properties of gabapentin (GBP) after myocardial infarction (MI) by suppressing M1 macrophage polarization. In this study, we further dissect...
The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery [0.03%]
肺不仅仅是气体交换的器官：免疫功能、血小板和药物发现的意义
Simon C Pitchford
Simon C Pitchford
The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action o...
Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation [0.03%]
Comirnaty引起的猪急性过敏和多器官炎症效应：刺突蛋白mRNA转染及炎性细胞因子上调的证据
László Dézsi,Gábor Kökény,Gábor Szénási et al.
László Dézsi et al.
Background and purpose: Rare but severe adverse events (AEs) associated with mRNA-lipid nanoparticle (LNP) COVID-19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying m...
Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1-linked episodic ataxia in mice [0.03%]
鼠尾草酸通过其电压感应器激活Kv1.1通道并纠正小鼠中的Kv1.1相关发作性共济失调
Rían W Manville,Ryan F Yoshimura,Hanh A Nguyen et al.
Rían W Manville et al.
Background and purpose: Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss-of-function mutations in the voltage-gated potassium channel Kv1.1 (KCNA1). Small molecules that...
sGC stimulator BAY 41-8543 improves survival and ventricular function in a rat model of doxorubicin-induced cardiomyopathy with nephrotic syndrome [0.03%]
可的松联合阿霉素致心肌病大鼠模型中一氧化氮/sGC信号通路刺激剂BAY 41-8543改善心脏功能和生存率
Olga Gawrys,Petra Škaroupková,Soňa Kikerlová et al.
Olga Gawrys et al.
Background and purpose: Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble gu...
Inhibition of leucine-rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation-network remodelling [0.03%]
雷富肽酶2(LRRK2)的抑制通过磷酸化网络重构促进外周轴突再生
Eun-Hae Jang,Eun Mo Yang,Gil Song et al.
Eun-Hae Jang et al.
Background and purpose: In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro-regenerative transcriptional programme. Path...
Tyrosine kinase 2 inhibition by GL-V9 treats psoriasiform dermatitis via macrophage-helper T-cell modulation [0.03%]
口服GL-V9通过调节巨噬细胞和辅助性T细胞治疗银屑病皮炎的机制研究
Leyi Chen,Haiyan Tu,Xiaohe Xu et al.
Leyi Chen et al.
Background and purpose: Psoriasis (PsO) is a chronic T lymphocyte-mediated inflammatory disease arising on a polygenic background. GL-V9, a structurally optimized flavonoid with reported anti-inflammatory and anti-fibroti...
Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression [0.03%]
cannabinoid cb1 变构配体通过抑制小鼠炎症性疼痛发挥作用，而不产生耐受性、运动障碍、记忆缺陷或呼吸抑制等作用
Ifeoluwa D Solomon,Sumanta Garai,Ganesh A Thakur et al.
Ifeoluwa D Solomon et al.
Background and purpose: Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whe...