Graeme I Lancaster,Andrew J Murphy
Graeme I Lancaster
Joanna R Kovalski,Davide Ruggero
Joanna R Kovalski
Selective translational control by PABPC1 phase separation regulates blast crisis and therapy resistance in chronic myeloid leukaemia [0.03%]
慢性髓性白血病中PABPC1相分离的选择性转录控制调节急性变和治疗抵抗性
Chenguang Sun,Xi Xu,Zhongyang Chen et al.
Chenguang Sun et al.
Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 fusion tyrosine kinase have revolutionized the treatment of chronic myeloid leukaemia (CML). However, the development of TKI resistance and the subsequent transition from the chronic ...
Taking on Parkinson's [0.03%]
抗击帕金森病
Stylianos Lefkopoulos
Stylianos Lefkopoulos
George Andrew S Inglis
George Andrew S Inglis
Clémentine Villeneuve,Kaitlin P McCreery,Sara A Wickström
Clémentine Villeneuve
Tissue deformations are a central feature of development, from early embryogenesis, growth and building the body plan to the establishment of functional organs. These deformations often result from active contractile forces generated by cel...
Yasmine J Liu,Jonathan Sulc,Johan Auwerx
Yasmine J Liu
Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome, which is matrilineally inher...
David A Calderwood,Derek Toomre
David A Calderwood
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer [0.03%]
PRMT5介导的精氨酸甲基化稳定GPX4以抑制癌症中的铁死亡过程
Yizeng Fan,Yuzhao Wang,Weichao Dan et al.
Yizeng Fan et al.
The activation of ferroptosis has shown great potential for cancer therapy from an unconventional perspective, but revealing the mechanisms underlying the suppression of tumour-intrinsic ferroptosis to promote tumorigenesis remains a challe...