Melissa J Hoyer,Cristina Capitanio,Ian R Smith et al. Melissa J Hoyer et al.

Bin Wang,Yongqiang Wang,Ting Pan et al. Bin Wang et al.

Maintaining innate immune homeostasis is critical for preventing infections and autoimmune diseases but effective interventions are lacking. Here we identified C864-C869-mediated intermolecular disulfide-linkage formation as a critical step...

Stylianos Lefkopoulos Stylianos Lefkopoulos

Angela R Parrish Angela R Parrish

Xinbo Wang,Peng Xu,Amanda Bentley-DeSousa et al. Xinbo Wang et al.

Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson's disease. Here we show that VPS13C, a bridge-like lipid-transport protein and a Parkinson's disease gene, is a sensor of lysosome stress or ...

Dong Han,Wan Xu,Hyun-Woo Jeong et al. Dong Han et al.

Conventional understanding dictates that mammalian neural stem cells (NSCs) exist only in the central nervous system. Here, we report that peripheral NSCs (pNSCs) exist outside the central nervous system and can be isolated from mouse embry...

Reiya Taniguchi,Clarisse Orniacki,Jan Philipp Kreysing et al. Reiya Taniguchi et al.

Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange, which is essential for eukaryotes. Mutations in the central scaffolding components of NPCs are associated with genetic diseases, but how they manifest only in specific tissue...

Sanjna Singh,Julian M Carosi,Linh Dang et al. Sanjna Singh et al.