The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate [0.03%]
染色质H3K9二甲基化位点的核周边定位及其在细胞命运决定中的作用
Harold C Marin,Charlie Allen,Eric Simental et al.
Harold C Marin et al.
Heterochromatic loci marked by histone H3 lysine 9 dimethylation (H3K9me2) are enriched at the nuclear periphery in metazoans, but the effect of spatial position on heterochromatin function has not been defined. Here we remove three nuclear...
Metabolic regulation of key developmental events during mammalian embryogenesis [0.03%]
哺乳动物胚胎发育过程中关键发育事件的代谢调控
Yuyan Xu,Wei Xie,Jin Zhang
Yuyan Xu
Metabolic regulation is critical in embryonic development and influences key processes such as fertilization, zygotic genome activation, cell compaction, implantation, gastrulation and organ development. Here we explore the interplay betwee...
Jim Lu Zhang,Yu-Chen Chang,Po-Hsuan Lai et al.
Jim Lu Zhang et al.
Mitochondria export Ca2+ via Na+/Ca2+ exchange machinery (mito-NCX) to regulate intracellular Ca2+ signalling and mitochondrial Ca2+ homeostasis. TMEM65 has recently been implicated as essential for mito-NCX, but its mechanisms and roles re...
A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis [0.03%]
ROS介导的氧化-O-葡萄糖酸化级联调控铁死亡
Hemeng Zhang,Jialin Ma,Chunyan Hou et al.
Hemeng Zhang et al.
Reactive oxygen species (ROS) play a crucial role in lipid peroxidation and the initiation of ferroptosis, markedly affecting chemotherapeutic drug resistance. However, the mechanisms by which ROS function and are sensed remain poorly under...
Retraction Note: Mitochondrial mechanotransduction through MIEF1 coordinates the nuclear response to forces [0.03%]
撤回 notice: 通过 MIEF1 的线粒体机械转导协调对力的核反应
Patrizia Romani,Giada Benedetti,Martina Cusan et al.
Patrizia Romani et al.
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells [0.03%]
分化、衰老和白血病会改变人类骨髓造血干细胞和祖细胞的代谢谱型
Maria-Eleni Lalioti,Mari Carmen Romero-Mulero,Noémie Karabacz et al.
Maria-Eleni Lalioti et al.
Metabolic cues are crucial for regulating haematopoietic stem and progenitor cells (HSPCs). However, the metabolic profile of human HSPCs remains poorly understood due to the limited number of cells and the scarcity of bone marrow samples. ...
Michael Salsaa,Gregory D Fairn
Michael Salsaa
Stylianos Lefkopoulos,Jan Żylicz
Stylianos Lefkopoulos
Wenqi Hu,Carmen Sancho-Serra,Carlos W Gantner et al.
Wenqi Hu et al.
The amnion is a critical extra-embryonic structure that supports foetal development, yet its ontogeny remains poorly defined. Here, using single-cell transcriptomics, we identified major cell types and subtypes in the human amnion across th...