Author Correction: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling [0.03%]
作者更正：量化结直肠癌类器官中单细胞ERK动力学，显示EGFR作为致癌MAPK途径信号放大的放大器
Bas Ponsioen,Jasmin B Post,Julian R Buissant des Amorie et al.
Bas Ponsioen et al.
Published Erratum
Nature cell biology. 2026 Jul 31. DOI:10.1038/s41556-026-02050-3 2026
Yanhong Shi
Yanhong Shi
The glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance [0.03%]
glycolytic酶PGAM1作为代谢-自噬检查点来协调生长和压力耐受性
Yi Zhang,Pengwei Zhao,Hangfei Liang et al.
Yi Zhang et al.
Cell survival requires tight coordination between growth-promoting metabolism and cellular quality-control pathways, yet how these processes are integrated remains unclear. Here we identify the conserved glycolytic enzyme PGAM1 as a metabol...
Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling [0.03%]
核小类3型PI3K协同激活饥饿特异性染色质重塑作用
Nathaniel F Henneman,Genki Kawamura,Ying Luo et al.
Nathaniel F Henneman et al.
Transcriptional remodelling during fasting ensures metabolic adaptation and provides health benefits across species. Although several regulators of fasting-induced transcription and chromatin are known, how nutrient levels directly influenc...
Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ [0.03%]
癌干细胞是肿瘤微环境的高反应性传感器并通过YAP/TAZ调节转移动力学
Binwu Tang,Jacob Minin,Victoria M Gonzalez et al.
Binwu Tang et al.
Cancer stem cells (CSCs) drive metastasis and therapy resistance, yet their behaviour within the complex tumour microenvironment remains poorly understood. Here we use a fluorescent reporter that marks CSCs to show that CSCs and their more ...
Veronica J Farmer,Amy S Gladfelter
Veronica J Farmer
Kelli F Johnson,Xiangning Dong,Yu-Hwai Tsai et al.
Kelli F Johnson et al.
The organization of diverse mesenchymal populations during human small intestinal development is critical for tissue architecture and function yet remains poorly defined. Here, to construct a comprehensive, tissue-scale map of the developin...
Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes [0.03%]
线粒体衍生囊泡驱动受损溶酶体的芽生型分裂
Yuanchun Luo,Jianglong Yu,Zhuofan Li et al.
Yuanchun Luo et al.
Lysosomes are central degradative organelles essential for cellular homeostasis, yet the mechanisms that maintain their integrity and function under stress remain incompletely understood. Here we identify a previously unrecognized lysosomal...
Shawn M Ferguson
Shawn M Ferguson
Matthew L Steinhauser,Yuan Liu,Stacey J Sukoff Rizzo et al.
Matthew L Steinhauser et al.
Lysosomes are essential regulators of cellular homeostasis. Emerging evidence positions lysosomes as both vulnerable targets and active drivers of ageing biology. During ageing, lysosomes exhibit impaired biogenesis, defective acidification...