Heidi Beate Bentzen,Maxence Gaillard,Iftach Nachman et al.
Heidi Beate Bentzen et al.
Human stem-cell-based embryo models (hSCBEMs) offer unprecedented opportunities for basic and translational research. However, the rapid pace of scientific developments in the field challenges the slower, traditional modes of ethics evaluat...
Morally relevant features warranting ethical oversight in human stem cell-based embryo models [0.03%]
Naomi Moris,Alfonso Martinez Arias,Martin Pera et al.
Naomi Moris et al.
Stem cell-based embryo models provide innovative ways to explore the principles of human development but also pose new challenges for regulation. Recent guidelines have argued for case-by-case evaluation of stem cell-based embryo model rese...
Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine-ZBTB5-mTORC1 axis [0.03%]
Junyu Xiang,Tao Wang,Shuoran Tian et al.
Junyu Xiang et al.
Acute activation of mTORC1 by amino acids (AAs) is pivotal for growth regulation, yet it remains unclear how the intracellular nutrient-sensing machinery might be rewired by environmental cues to execute distinct functions. Here we report t...
Xinyi Chen,Yinglin Situ,Yuexuan Yang et al.
Xinyi Chen et al.
Trogocytosis, the transfer of plasma membrane fragments during cell-cell contact, offers potential for macromolecular delivery but is limited by the uncertain fate of trogocytosed molecules, restriction to membrane cargo and unclear general...
Joshua D Frenster,Stephen Babin,Pablo Casani-Galdon et al.
Joshua D Frenster et al.
Selective elimination of suboptimal cells is critical for the developmental integrity of early mammalian embryogenesis. Cell competition is a non-autonomous quality control in which 'winner' cells outcompete viable but suboptimal 'loser' ce...
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours [0.03%]
通过GITR信号活化COTL1⁺NK细胞可克服tsMHC-I缺陷型肿瘤的免疫检查点抑制抵抗性
Wenhua You,Chupeng Hu,Yuhan Zhang et al.
Wenhua You et al.
Patients with impaired tumour-specific major histocompatibility complex class I (tsMHC-Iimpaired) often fail to respond to immune checkpoint blockade (ICB), presenting a major clinical challenge. However, through our multicentre investigati...
An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs [0.03%]
表皮生长因子受体共扩增的长链非编码RNA HELDR通过KAT7驱动的基因程序促进胶质母细胞瘤恶性进展
Xiaozhou Yu,Xiao Song,Richard A Schäfer et al.
Xiaozhou Yu et al.
EGFR amplification frequently occurs within extrachromosomal DNAs (ecDNAs) and is the most prevalent mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments has been unsuccessful. Here we show a long non-coding RNA (lncRN...
Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells [0.03%]
nonsense-mediated mRNA衰减在多能干细胞中守护端粒
Marta Markiewicz-Potoczny,Si Young Lee,Soniya Chatterjee et al.
Marta Markiewicz-Potoczny et al.
Telomeres are protective DNA caps at chromosome ends that prevent cells from mistakenly recognizing them as broken DNA. These structures are safeguarded by a protein complex called Shelterin, particularly through the TRF2 protein encoded by...