The guinea pig serves as an alternative model to study human preimplantation development [0.03%]
Guinea猪作为研究人类植入前发育的替代模型
Jesica Romina Canizo,Cheng Zhao,Sophie Petropoulos
Jesica Romina Canizo
Preimplantation development is an important window of human embryogenesis. However, ethical constraints and the limitations involved in studying human embryos often necessitate the use of alternative model systems. Here we identify the guin...
Supra-second tracking and live-cell karyotyping reveal principles of mitotic chromosome dynamics [0.03%]
超秒追踪和活细胞核型分析揭示有丝分裂染色体动力学原理
Rumen Stamatov,Sonya Uzunova,Yoana Kicheva et al.
Rumen Stamatov et al.
Mitotic chromosome dynamics are essential for the three-dimensional organization of the genome during the cell cycle, but the spatiotemporal characteristics of this process remain unclear due to methodological challenges. While Hi-C methods...
Zhi Zong,Jiang Ren,Bing Yang et al.
Zhi Zong et al.
Given its various roles in cellular functions, lactate is no longer considered a waste product of metabolism and lactate sensing is a pivotal step in the transduction of lactate signals. Lysine lactylation is a recently identified post-tran...
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency [0.03%]
出版更正：mRNA的m6A甲基化在暂停多能性期间调控转录静默状态
Evelyne Collignon,Brandon Cho,Giacomo Furlan et al.
Evelyne Collignon et al.
Published Erratum
Nature cell biology. 2025 Apr 2. DOI:10.1038/s41556-025-01664-3 2025
Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study [0.03%]
骨髓造血干细胞活性的调节作为心肌梗死后的一种治疗策略：一项动物研究
Jasmin Rettkowski,Mari Carmen Romero-Mulero,Indranil Singh et al.
Jasmin Rettkowski et al.
Myocardial infarction (MI) is a major global health concern. Although myeloid cells are crucial for tissue repair in emergency haematopoiesis after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Bone marrow ...
Xiaoting Hou,Chang Ren,Jing Jin et al.
Xiaoting Hou et al.
Cell motility and adhesion are fundamental components for diverse physiological functions, including embryonic development, immune responses and tissue repair. Dysregulation of these processes can lead to a range of diseases, including canc...
Céline Vrancx,Wim Annaert
Céline Vrancx
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease [0.03%]
阿尔茨海默病转分化的神经元中的蛋白质稳态和溶酶体修复缺陷
Ching-Chieh Chou,Ryan Vest,Miguel A Prado et al.
Ching-Chieh Chou et al.
Ageing is the most prominent risk factor for Alzheimer's disease (AD). However, the cellular mechanisms linking neuronal proteostasis decline to the characteristic aberrant protein deposits in the brains of patients with AD remain elusive. ...
Jay Xiaojun Tan
Jay Xiaojun Tan
Felix Lange,Michael Ratz,Jan-Niklas Dohrke et al.
Felix Lange et al.
Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others. Th...