ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression [0.03%]
醛脱氢酶4家族成员A1作为线粒体丙酮酸载体复合物的活性成分，维持丙酮酸进入三羧酸循环以抑制肿瘤产生中的作用
Che-Chia Hsu,Chi-Yun Wang,Rajesh Kumar Manne et al.
Che-Chia Hsu et al.
MPC1 and MPC2 are two well-known components of the mitochondrial pyruvate carrier (MPC) complex maintaining MPC activity to transport pyruvate into mitochondria for tricarboxylic acid (TCA) cycle entry in mammalian cells. It is currently un...
Import mechanism of peroxisomal proteins with an N-terminal signal sequence [0.03%]
具有N端信号序列的过氧化物酶体蛋白的输入机制
Michael L Skowyra,Tom A Rapoport
Michael L Skowyra
Most proteins imported into peroxisomes use a carboxy-terminal PTS1 signal, which is recognized by soluble receptors that transport the cargo through a nuclear pore-like conduit in the peroxisomal membrane formed by the tyrosine and glycine...
Heyang Wei,Hongdan Zheng,Siqing Wang et al.
Heyang Wei et al.
Transcriptional silencing of hypermethylated tumour suppressor genes is a hallmark of tumorigenesis but the underlying mechanism remains enigmatic. Here we show that methyl-CpG-binding domain protein 2 (MBD2) forms nuclear condensate in div...
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [0.03%]
α-酮戊二酸促进人胚胎干细胞向滋养层细胞的诱导和成熟
Karlien Van Nerum,Anne Wenzel,Lidia Argemi-Muntadas et al.
Karlien Van Nerum et al.
Development and lineage choice are driven by interconnected transcriptional, epigenetic and metabolic changes. Specific metabolites, such as α-ketoglutarate (αKG), function as signalling molecules affecting the activity of chromatin-modif...
Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans [0.03%]
人类成纤维细胞多样性的发育起源、组织线索和病理信号的影响
Marta Torregrossa,Lindsay Davies,Machens Hans-Günther et al.
Marta Torregrossa et al.
Fibroblasts, once perceived as a uniform cell type, are now recognized as a mosaic of distinct populations with specialized roles in tissue homeostasis and pathology. Here we provide a global overview of the expanding compendium of fibrobla...
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth [0.03%]
髓母细胞瘤脑膜转移灶重塑局部脑膜微环境以促进进一步的转移定植和生长
Namal Abeysundara,Alexandra Rasnitsyn,Vernon Fong et al.
Namal Abeysundara et al.
Leptomeningeal metastases are the major source of morbidity and mortality for patients with medulloblastoma. The biology of the leptomeningeal metastases and the local tumour microenvironment are poorly characterized. Here we show that meta...
Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function [0.03%]
肿瘤间质液富集的磷胆碱抑制t细胞功能
Yupeng Wang,Drew Wilfahrt,Patrick Jonker et al.
Yupeng Wang et al.
Nutrient stress represents an important barrier for anti-tumour immunity, and tumour interstitial fluid often contains metabolites that hinder immune function. However, it is difficult to isolate the effects of tumour nutrient stress from o...
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism [0.03%]
线粒体NADPH促进脂肪酸合成及辅酶A的硫辛基化以驱动氧化代谢
Dohun Kim,Rushendhiran Kesavan,Kevin Ryu et al.
Dohun Kim et al.
Nicotinamide adenine dinucleotide phosphate (NADPH) is a vital electron donor essential for macromolecular biosynthesis and protection against oxidative stress. Although NADPH is compartmentalized within the cytosol and mitochondria, the sp...