Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks [0.03%]
转录抑制促进DNA双链断裂处RNA:DNA杂交体的积累
Florian Saur,Emma Lesage,Lea Pradel et al.
Florian Saur et al.
RNA:DNA hybrids accumulate at DNA double-strand breaks (DSBs) and were shown to regulate homologous recombination repair. The mechanism responsible for the formation of these non-canonical RNA:DNA structures remains unclear although they we...
Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport [0.03%]
鞘氨醇-1-磷酸信号通过活化E-Syt1促进HDL来源的胆固醇运输
Zizhen Xu,Ying Meng,Jonathan St-Germain et al.
Zizhen Xu et al.
Cholesterol derived from high-density lipoprotein (HDL) is rapidly redistributed to intracellular compartments in steroidogenic and bile-producing cells, but the molecular mechanisms governing this essential transport process remain poorly ...
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA [0.03%]
心理压力通过细胞外囊泡RNA转移诱导ALKBH5缺乏，从而促进肿瘤神经支配和胰腺癌的发展
Ziming Chen,Yifan Zhou,Chunling Xue et al.
Ziming Chen et al.
The pathological role and mechanism of psychological stress in cancer progression are little known. Here we show in a mouse model that psychological stress drives pancreatic ductal adenocarcinoma (PDAC) progression by stimulating tumour ner...
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells [0.03%]
整合素β1磷酸化的动态调节支持乳腺癌细胞的侵袭性
James R W Conway,Omkar Joshi,Jasmin Kaivola et al.
James R W Conway et al.
Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized importance of integrin phosphorylation in several biological proce...
Author Correction: Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism [0.03%]
作者更正：线粒体NADPH为线粒体脂肪酸合成和泛素化提供动力以增强氧化代谢
Dohun Kim,Rushendhiran Kesavan,Kevin Ryu et al.
Dohun Kim et al.
Published Erratum
Nature cell biology. 2025 May 22. DOI:10.1038/s41556-025-01695-w 2025
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation [0.03%]
中性粒细胞通过分泌与外泌体结合的DNA来解决非无菌急性炎症反应
Subhash B Arya,Samuel P Collie,Yang Xu et al.
Subhash B Arya et al.
Acute inflammation, characterized by a rapid influx of neutrophils, is a protective response that can lead to chronic inflammatory diseases when left unresolved. We previously showed that secretion of LTB4-containing exosomes via nuclear en...
Stylianos Lefkopoulos
Stylianos Lefkopoulos
Sabrya Carim
Sabrya Carim
Stem cells in the clinic [0.03%]
干细胞的临床应用
Stylianos Lefkopoulos
Stylianos Lefkopoulos