ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome [0.03%]
锌指基因ZNF280A连接DNA双链断裂修复与人类染色体22q11.2远端缺失综合症
Thomas L Clarke,Hyo Min Cho,Ilaria Ceppi et al.
Thomas L Clarke et al.
DNA double-strand breaks (DSB) are among the most deleterious forms of DNA damage and, if unresolved, result in DNA mutations and chromosomal aberrations that can cause disease, including cancer. Repair of DSBs by homologous recombination r...
Gayathri Muthukumar,Jonathan S Weissman
Gayathri Muthukumar
Mitochondria are critical double-membraned organelles that act as biosynthetic and bioenergetic cellular factories, with the outer membrane providing an interface with the rest of the cell. Mitochondrial outer membrane proteins regulate a v...
Cell state-specific cytoplasmic density controls spindle architecture and scaling [0.03%]
细胞状态特异的胞质密度控制纺锤体结构和尺度效应
Tobias Kletter,Omar Muñoz,Sebastian Reusch et al.
Tobias Kletter et al.
Mitotic spindles are dynamically intertwined with the cytoplasm they assemble in. How the physicochemical properties of the cytoplasm affect spindle architecture and size remains largely unknown. Using quantitative biochemistry in combinati...
Helena Klara Jambor
Helena Klara Jambor
Endoplasmic reticulum-mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis [0.03%]
内质网-线粒体接触是铁死亡驱动磷脂过氧化的主要热点区域
Maria Livia Sassano,Yulia Y Tyurina,Antigoni Diometzidou et al.
Maria Livia Sassano et al.
The peroxidation of membrane phospholipids (PLs) is a hallmark of ferroptosis. The endoplasmic reticulum and mitochondria have been implicated in ferroptosis, but whether intracellular PL peroxidation ensues at their contact sites (endoplas...
Qidong Li,Boyi Gan
Qidong Li
Sunny Sharma,Xinfu Jiao,Jun Yang et al.
Sunny Sharma et al.
Epitranscriptomic modifications play pivotal roles in regulating RNA stability, localization and function. Recently, glycosylation has also emerged as an RNA modification, though its functional implications remain unclear. Here we report th...
Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells [0.03%]
乳酸脱氢酶B促进二硫键蛋白降解并导致肿瘤浸润CD8⁺T细胞衰竭
Jie Wan,Jian-Hong Shi,Min Shi et al.
Jie Wan et al.
The aberrant accumulation of intracellular disulfides promotes cancer cell disulfidptosis; however, how disulfide stress influences tumour-infiltrating CD8+ T cell function remains unknown. Here we demonstrate that lactate dehydrogenase B (...