Autophagy-targeted NBR1-p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH [0.03%]
自噬靶向的NBR1-p62/SQSTM1复合物通过隔离ITCH促进乳腺癌转移
Gourish Mondal,Hugo Gonzalez,Timothy Marsh et al.
Gourish Mondal et al.
Autophagy deficiency in breast cancer promotes metastasis through the accumulation of the autophagy cargo receptor NBR1. Here we show that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1-p62/SQSTM1 c...
Terytty Yang Li,Arwen W Gao,Rendan Yang et al.
Terytty Yang Li et al.
Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive...
Huilun Helen Wang,Ida Biunno,Shengyi Sun et al.
Huilun Helen Wang et al.
Endoplasmic reticulum-associated degradation (ERAD) is a critical quality control mechanism responsible for eliminating misfolded or unassembled proteins. It maintains endoplasmic reticulum homeostasis, ensures a proper folding environment ...
Author Correction: A two-step mechanism for epigenetic specification of centromere identity and function [0.03%]
作者更正：染色体着丝粒身份和功能表观遗传特化的两步机制
Daniele Fachinetti,H Diego Folco,Yael Nechemia-Arbely et al.
Daniele Fachinetti et al.
Published Erratum
Nature cell biology. 2025 Jun 23. DOI:10.1038/s41556-025-01718-6 2025
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates [0.03%]
YAP调控TDP-43凝聚体的动态平衡并抑制病理性聚集
Jiaqi Zhang,Jiaojiao Hu,Ruogu Liu et al.
Jiaqi Zhang et al.
Recent studies exploring the underlying pathomechanisms of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder, have focused on biomolecular condensates. Here we reveal an unexpected function for YAP, a central component of t...
Ancély Ferreira Dos Santos,José Pedro Friedmann Angeli
Ancély Ferreira Dos Santos
Crossover patterning through condensation and coarsening of pro-crossover factors [0.03%]
重组通过预重组因子的凝聚和粗化实现
Liangyu Zhang,Weston Stauffer,Chenshu Liu et al.
Liangyu Zhang et al.
Meiotic recombination mixes genetic information from parental genomes, creating unique combinations of alleles. During meiotic prophase, each homologue pair must undergo at least one crossover to segregate faithfully. Only a few recombinati...
Gabriel Cavin-Meza,Rebecca Heald
Gabriel Cavin-Meza
Grow up, beta cells [0.03%]
胰岛素β细胞快长大吧
Angela R Parrish
Angela R Parrish
Daryl J V David
Daryl J V David