Sabrya Carim
Sabrya Carim
Zhe Wang
Zhe Wang
P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance [0.03%]
P4 ATPase控制磷脂酰肌醇膜不对称性和新霉素抗性
Bhawik K Jain,H Diessel Duan,Christina Valentine et al.
Bhawik K Jain et al.
The aminoglycoside antibiotic neomycin has robust antibacterial properties, yet its clinical utility is curtailed by its nephrotoxicity and ototoxicity. The mechanism by which the polycationic neomycin enters specific eukaryotic cell types ...
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation [0.03%]
回顾性和多因素单细胞谱系分析揭示X染色体失活过程中的连续染色质重构
Samy Kefalopoulou,Pim M J Rullens,Kim L de Luca et al.
Samy Kefalopoulou et al.
The regulation of gene expression is governed at multiple levels of chromatin organization. However, how gene regulation is co-ordinated remains relatively unexplored. Here we develop Dam&ChIC, a method that enables retrospective and multif...
Never let you go [0.03%]
永远不会放开你
Angela R Parrish
Angela R Parrish
Anna Bright,Leyla Anne Akay,Joel Blanchard et al.
Anna Bright et al.
João Pedro de Magalhães
João Pedro de Magalhães
Ageing is a complex biological process whose underlying mechanisms remain contentious. Nonetheless, due to an ageing global population and the rising incidence of age-related diseases, understanding why we age is one of the most important s...
REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes [0.03%]
REM转录因子和GDE1通过招募RNA聚合酶IV转录复合物来塑造DNA甲基化景观
Zhongshou Wu,Yan Xue,Shuya Wang et al.
Zhongshou Wu et al.
In plants, the maintenance of DNA methylation is controlled by several self-reinforcing loops involving histone methylation and non-coding RNAs. However, how methylation is initially patterned at specific genomic loci is largely unknown. He...
The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness [0.03%]
Vps13样蛋白BLTP2通过调节磷脂酰乙醇胺水平维持质膜流动性及乳腺癌恶性进展
Subhrajit Banerjee,Stephan Daetwyler,Xiaofei Bai et al.
Subhrajit Banerjee et al.
Lipid transport proteins (LTPs) facilitate non-vesicular lipid exchange between cellular compartments and have critical roles in lipid homeostasis. A recently identified family of bridge-like LTPs (BLTPs) is thought to form lipid-transporti...