Olga Afonso,Ludovic Dumoulin,Karsten Kruse et al.
Olga Afonso et al.
During early embryogenesis, fast mitotic cycles without interphase lead to a decrease in cell size, while scaling mechanisms must keep cellular structures proportional to cell size. For instance, as cells become smaller, if the position of ...
Flow, sense and divide [0.03%]
流动、感知与分割
Nicoletta I Petridou
Nicoletta I Petridou
An avoidance segment resolves a lethal nuclear-mitochondrial targeting conflict during ribosome assembly [0.03%]
一个回避区段在核糖体组装过程中解决了一个致死的核质靶向冲突
Michaela Oborská-Oplová,Alexander Gregor Geiger,Erich Michel et al.
Michaela Oborská-Oplová et al.
The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to mitochondria for ribosome production poses a logistical challenge for cellular targeting pathways. Here we report the discovery of a conserved mitocho...
Kanda M Borgognoni,Robin E Stanley
Kanda M Borgognoni
SNORD113-114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery [0.03%]
SNORD113-114簇通过调控翻译机制维持造血干细胞的自我更新能力
Hui Wang,Zhaoru Zhang,Chenxi Han et al.
Hui Wang et al.
Haematopoietic stem cells (HSCs) self-renew and differentiate to replenish the pool of blood cells, which require a low but finely tuned protein synthesis rate. Nonetheless, the translatome landscape in HSCs and how the translation machiner...
Nikolaus Pfanner,Fabian den Brave,Thomas Becker
Nikolaus Pfanner
Mitochondria have to import a large number of precursor proteins from the cytosol. Chaperones keep these proteins in a largely unfolded state and guide them to the mitochondrial import sites. Premature folding, mitochondrial stress and impo...
Stylianos Lefkopoulos
Stylianos Lefkopoulos
Stylianos Lefkopoulos
Stylianos Lefkopoulos