ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion [0.03%]
ADSL生成的延胡索酸盐结合并抑制STING以促进肿瘤免疫逃逸
Yuran Duan,Zhiqiang Hu,Peng Han et al.
Yuran Duan et al.
Highly aggressive tumours have evolved to restrain the cGAS-STING pathway for immune evasion, and the mechanisms underlying this hijacking remain unknown. Here we demonstrate that hypoxia induces robust STING activation in normal mammary ep...
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens [0.03%]
使用可扩展的单细胞扰动筛选系统性重建分子通道标志物
Longda Jiang,Carol Dalgarno,Efthymia Papalexi et al.
Longda Jiang et al.
Recent advancements in functional genomics have provided an unprecedented ability to measure diverse molecular modalities, but predicting causal regulatory relationships from observational data remains challenging. Here, we leverage pooled ...
Publisher Correction: Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis [0.03%]
出版更正：生长因子触发的去唾液酸作用控制糖脂凝集素驱动的内吞作用
Ewan MacDonald,Alison Forrester,Cesar A Valades-Cruz et al.
Ewan MacDonald et al.
Published Erratum
Nature cell biology. 2025 Feb 25. DOI:10.1038/s41556-025-01643-8 2025
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis [0.03%]
拟兰芥中通过动态中间cis-高尔基体管状网从内质网到高尔基体的运输过程
Louise Fougère,Magali Grison,Patricia Laquel et al.
Louise Fougère et al.
Endoplasmic reticulum (ER)-to-Golgi trafficking is a central process of the secretory system of eukaryotic cells that ensures proper spatiotemporal sorting of proteins and lipids. However, the nature of the ER-Golgi intermediate compartment...
Intratumour oxidative hotspots provide a niche for cancer cell dissemination [0.03%]
肿瘤内氧化热点为癌细胞扩散提供生态位
Yoshifumi Ueda,Shigeki Kiyonaka,Laura M Selfors et al.
Yoshifumi Ueda et al.
Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic...
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis [0.03%]
生长因子触发的去唾液酸化控制糖脂凝集素驱动的内吞作用
Ewan MacDonald,Alison Forrester,Cesar A Valades-Cruz et al.
Ewan MacDonald et al.
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we ...
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties [0.03%]
Blebbisomes是具有细胞特性的大型富含细胞器的胞外囊泡
Dennis K Jeppesen,Zachary C Sanchez,Noah M Kelley et al.
Dennis K Jeppesen et al.
Cells secrete a large variety of extracellular vesicles (EVs) to engage in cell-to-cell and cell-to-environment intercellular communication. EVs are functionally involved in many physiological and pathological processes by interacting with ...
Crislyn D&#x;Souza-Schorey,Dolores Di Vizio
Crislyn D&#x;Souza-Schorey
Theresa Willem,Vladimir A Shitov,Malte D Luecken et al.
Theresa Willem et al.
Recent machine-learning (ML)-based advances in single-cell data science have enabled the stratification of human tissue donors at single-cell resolution, promising to provide valuable diagnostic and prognostic insights. However, such insigh...
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness [0.03%]
细胞形状、基质和组织动力学的耦合确保了胚胎模式形成的稳健性
Prachiti Moghe,Roman Belousov,Takafumi Ichikawa et al.
Prachiti Moghe et al.
Tissue patterning coordinates morphogenesis, cell dynamics and fate specification. Understanding how precision in patterning is robustly achieved despite inherent developmental variability during mammalian embryogenesis remains a challenge....