Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy [0.03%]
基于菊粉凝胶的口服免疫疗法重塑小肠微生态并抑制食物过敏
Kai Han,Fang Xie,Olamide Animasahun et al.
Kai Han et al.
Despite the potential of oral immunotherapy against food allergy, adverse reactions and loss of desensitization hinder its clinical uptake. Dysbiosis of the gut microbiota is implicated in the increasing prevalence of food allergy, which wi...
Into the attosecond era [0.03%]
进入阿秒时代
Eirini Maniou,Silvia Todros,Anna Urciuolo et al.
Eirini Maniou et al.
Morphogenesis requires embryonic cells to generate forces and perform mechanical work to shape their tissues. Incorrect functioning of these force fields can lead to congenital malformations. Understanding these dynamic processes requires t...
Synthetic extremophiles via species-specific formulations improve microbial therapeutics [0.03%]
通过物种特异性配方合成极端环境耐受微生物以改善微生物疗法
Miguel Jimenez,Johanna L&#x;Heureux,Emily Kolaya et al.
Miguel Jimenez et al.
Microorganisms typically used to produce food and pharmaceuticals are now being explored as medicines and agricultural supplements. However, maintaining high viability from manufacturing until use remains an important challenge, requiring s...
Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids [0.03%]
基于患者胰腺癌类器官的 rigidity 介导的化学抗性研究
Bauer L LeSavage,Daiyao Zhang,Carla Huerta-López et al.
Bauer L LeSavage et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour phenotype has been difficult to dissect. H...
Mengwei He,William J Davids,Andrew J Breen et al.
Mengwei He et al.
Medium- and high-entropy alloys are an emerging class of materials that can exhibit outstanding combinations of strength and ductility for engineering applications. Computational simulations have suggested the presence of short-range order ...
Marcus E Peter,Maartje M C Bastings
Marcus E Peter
Philip Ball
Philip Ball
José Capmany,Daniel Pérez-López
José Capmany
Roy van der Meel,Francesca Grisoni,Willem J M Mulder
Roy van der Meel