Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids
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Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour phenotype has been difficult to dissect. Here we design and en... ...
