Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies [0.03%]
癌症免疫检查点的翻译后修饰：机制和治疗策略
Haiqing Jia,Lei Jiang,Xiaoyu Shen et al.
Haiqing Jia et al.
Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging. Protein post-translational modifications (PTMs) are criti...
M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression [0.03%]
N6-甲基化circRAPGEF5通过IGF2BP2/NUP160介导的自噬抑制驱动肺腺癌进展和转移
Liqun Ling,Tianqi Hu,Chenkang Zhou et al.
Liqun Ling et al.
Background: Lung adenocarcinoma (LUAD), the predominant histological subtype of non-small cell lung cancer, demonstrates critical regulatory involvement of RNA-binding proteins (RBPs) and circular RNAs (circRNAs) in tumor...
Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives [0.03%]
基于CAR的细胞疗法治疗实体瘤：挑战、策略和前景
Sarkar Sardar Azeez,Raya Kh Yashooa,Shukur Wasman Smail et al.
Sarkar Sardar Azeez et al.
Chimeric antigen receptor-cell therapies have demonstrated remarkable success in haematological malignancies but face significant hurdles in solid tumours. The hostile tumour microenvironment, antigen heterogeneity, limited tumour infiltrat...
Promising therapeutic efficacy and safety of a novel integrin α6-targeting peptide-drug conjugate in lung adenocarcinoma [0.03%]
一种新型整合素α6靶向肽-药物偶联物在肺腺癌治疗中的疗效和安全性评估
Wuyou Gao,Qiaoli Wang,Shibing Li et al.
Wuyou Gao et al.
Background: Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, with poor prognosis due to rapid tumor growth and resistance to current treatments. Thus, the identification of novel biomarkers and the...
Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation [0.03%]
非经典的ALK7通路通过β-连环素/MMP介导的基底膜降解和血管入侵促进胰腺癌转移
Anna M Kolarzyk,Yujin Kwon,Elizabeth Oh et al.
Anna M Kolarzyk et al.
Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood. Transforming growth factor beta (TGFβ) receptors have been ex...
Targeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential [0.03%]
靶向B细胞非霍奇金淋巴瘤中的CD30L：新型肽缀合物及其治疗潜力
Chaowen Shi,Tianzheng Lan,Yufeng Gao et al.
Chaowen Shi et al.
Background: B-cell non-Hodgkin lymphoma (B-NHL) constitutes the majority of NHL cases. Patients with B-NHL often experience multiple recurrences, necessitating several lines of antitumor therapy, and develop drug resistan...
IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC [0.03%]
IFITM3通过调节MHC-I增强免疫敏感性并与抗PD-1/-L1治疗在小细胞肺癌中的疗效相关
Yanan Cui,Tianyu Qiu,Jiale Wang et al.
Yanan Cui et al.
Background: Most small cell lung cancer (SCLC) patients exhibit resistance to immune checkpoint inhibitors (ICIs) and demonstrate downregulation of major histocompatibility complex class I (MHC-I) molecules. This study ai...
CircERC1 facilitates chemoresistance through inhibiting pyroptosis and remodeling extracellular matrix in pancreatic cancer [0.03%]
circERN1通过抑制焦亡和重塑细胞外基质促进胰腺癌化疗耐药性
Jian Zhang,Shengnan Lv,Xinyu Peng et al.
Jian Zhang et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) resists to neoadjuvant treatment even though overall survival (OS) is transiently prolonged while the underlying mechanism of this drug resistance remains elusive. ...
STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis [0.03%]
STK3是YAP1的转录靶点，在胃癌发生过程中介导Hippo和Wnt信号通路间的相互作用
Fuda Xie,Yang Lyu,Bonan Chen et al.
Fuda Xie et al.
Background: Serine/threonine kinase 3 (STK3) is recognized as a key regulator in Hippo pathway and a tumor-suppressing gene in various cancer types. However, its non-canonical role has been gradually revealed in cancer de...
Correction: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer [0.03%]
纠正：THBS2+癌症相关成纤维细胞通过COL8A1介导的PI3K/AKT活化促进结直肠癌上皮间质转化导致奥沙利铂耐药性
Xing Zhou,Jiashu Han,Anning Zuo et al.
Xing Zhou et al.
Published Erratum
Molecular cancer. 2025 Jun 26;24(1):184. DOI:10.1186/s12943-025-02388-6 2025