Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects [0.03%]
靶向线粒体稳态的抗癌治疗策略：现状与未来展望
Hongling Zhong,Renjie Pan,Yuzhen Ouyang et al.
Hongling Zhong et al.
Mitochondria are central to health and disease by precisely regulating metabolism and interacting closely with other organelles. Mitochondrial dysfunction contributes to the initiation and development of numerous diseases, including cancer....
Spatiotemporal dynamics of tumor-associated neutrophils: bridging the gap between cancer progression and immunotherapy [0.03%]
肿瘤相关中性粒细胞的时空动态特性：弥合癌症进展与免疫治疗之间的差距
Xiangyuan Chu,Junying Ma,Shihua Li et al.
Xiangyuan Chu et al.
Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns [0.03%]
局部转移扩散与二次性器官内播散：两种由根本不同的转移定植模式导致的神经外科死亡原因
Dorde Komljenovic,Tobias Bäuerle,Jessica Alves-de-Lima et al.
Dorde Komljenovic et al.
Background: Neurological failure contributes to 15-50% of deaths in patients with brain metastases, yet the underlying mechanisms remain poorly understood. Clinical causes range from local compression to meningeal metasta...
A paracrine-to-autocrine shunt of GREM1 fuels colorectal cancer metastasis via ACVR1C [0.03%]
通过ACVR1C促进结直肠癌转移的GREM1旁分泌-自分泌环路
Huaixiang Zhou,Qunlong Jin,Zhang Fu et al.
Huaixiang Zhou et al.
LncRNA PVT1 in human cancers: genomic complexity, isoforms, functional elements, mechanism of action, subcellular localization and possible role as a therapeutic target [0.03%]
人类癌症中的长链非编码RNA PVT1：基因组复杂性、异构体、功能元件、作用机制、亚细胞定位及其作为治疗靶点的潜在作用
Chen Li,Francisco Alejandro Lagunas-Rangel,Lutao Du et al.
Chen Li et al.
Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials [0.03%]
结直肠癌的癌症干细胞驱动的药物耐药性：分子特征和治疗潜力
Minfeng Zhou,Huifang Niu,Dandan Cui et al.
Minfeng Zhou et al.
Colorectal cancer (CRC) remains a major global health burden, with therapeutic resistance accounting for the majority of treatment failures and cancer-related deaths. Cancer stem cells (CSCs), which possess intrinsic drug tolerance and self...
Lactylation in cancer: molecular mechanisms and advances in clinical study [0.03%]
癌症中的乳酰化：分子机制和临床研究进展
Jiale Li,Changfeng Miao,Haijun Guo et al.
Jiale Li et al.
Lysine lactylation (Kla), first described in 2019, is an emerging post-translational modification that converts lactate availability into changes in chromatin state and protein function. In cancer, where glycolysis and microenvironmental hy...
piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer [0.03%]
三阴性乳腺癌中WTAP介导的m6A甲基化重编程通过piR-1170驱动脑转移和免疫逃逸
Yongzhou Luo,Wenwen Tian,Xudong Zhu et al.
Yongzhou Luo et al.
Notch signaling in the tumor microenvironment: recent advances and targeted therapeutics [0.03%]
肿瘤微环境中的诺特定理信号传导：最近的研究进展与靶向治疗药物
Di Chen,Xinyu Gu,Jingdian Liu et al.
Di Chen et al.
METTL3-mediated m6A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca2+ signaling [0.03%]
METTL3介导的CACNA1E位点m6A修饰通过增强WNT7B介导的Ca2+信号促进骨肉瘤进展和化学抗性
Chaotao Chen,Kai Xiong,Feiyuan Liang et al.
Chaotao Chen et al.
Background: Osteosarcoma (OS) is the most prevalent primary cancer of the bone. Metastasis and chemoresistance are the major obstacles to the improvement of OS prognosis, in which N6-methyladenosine (m6A) modification pla...