Extracellular vesicles cargo orchestration in colorectal cancer: immune evasion, stromal remodeling, and therapeutic frontiers [0.03%]
结直肠癌中外泌体装载物的调控：免疫逃逸、基质重塑和治疗前沿
Yukang Lu,Xiulan Liu,Tingting Zhang et al.
Yukang Lu et al.
Extracellular vesicles (EVs), as pivotal "messengers" in intercellular communication within the tumor microenvironment (TME), play multifaceted regulatory roles in the initiation, progression, and therapeutic response of colorectal cancer (...
CircRNF10 sequestrates β-catenin by a dual regulatory circuit of direct degradation and a miR-1275/DKK3-mediated inhibition in driver gene- negative lung adenocarcinoma [0.03%]
环状RNA RNF10通过直接降解和miR-1275/DKK3介导的抑制作用的双重调控电路在驱动基因阴性的肺腺癌中结合β-catenin蛋白质
Xiaohua Situ,Xinwei Wang,Xiting Liao et al.
Xiaohua Situ et al.
Background: Circular RNAs (circRNAs) exert critical regulatory functions in tumor biology by modulating pathways associated with oncogenesis or tumor suppression. Despite substantial progress in elucidating their roles in...
Hengshuo Liu,Xingyu Xiong,Weizhen Zhu et al.
Hengshuo Liu et al.
Gut microbiota-derived metabolites are emerging as systemic "remote immunoregulators" that shape tumor immunity across tissues. Integrating evidence across short-chain fatty acids, tryptophan derivatives, secondary bile acids, polyamines an...
Correction: Harnessing ExDNA for precision Exatecan delivery in cancer: a novel antibody-drug conjugate approach [0.03%]
纠正：利用外源性DNA精准递送抗癌药物Exatecan：一种新型抗体-药物偶联物方法
Zaira Ianniello,Huimei Lu,Elias Quijano et al.
Zaira Ianniello et al.
Published Erratum
Molecular cancer. 2025 Dec 3;24(1):304. DOI:10.1186/s12943-025-02539-9 2025
Development and validation of a small extracellular vesicle-derived RNA signature for early diagnosis of lung adenocarcinoma and prognosis in advanced stages [0.03%]
用于肺癌早期诊断和晚期预后的微小细胞外囊泡衍生RNA标志物的开发及验证
Rui Meng,Yanjun Gao,Zheng Peng et al.
Rui Meng et al.
This study developed and validated a diagnostic signature comprising five small extracellular vesicle (sEV)-derived long RNAs (ATF4, GRAP2, MCL1, PAK2, PIK3CB) for distinguishing early-stage lung adenocarcinoma (LUAD) from benign pulmonary ...
Multi-omic profiling provides insights into the heterogeneity, microenvironmental features, and biomarker landscape of small-cell lung cancer [0.03%]
多组学谱分析可提供小细胞肺癌异质性、微环境特征和生物标志物图谱的见解
Mingchao Xie,Miljenka Vuko,Shashank Saran et al.
Mingchao Xie et al.
Background: Greater understanding of differential therapeutic sensitivity, specifically to immunotherapy, in small-cell lung cancer (SCLC) is required. Me...
Yansheng Wu,Hao Li,Kai Yue et al.
Yansheng Wu et al.
Ferroptosis is a form of cell death, distinct from apoptosis, necrosis and autophagy. It is a novel programmed cell death (PCD) triggered by iron accumulation and peroxidation associated with intracellular iron metabolism disorders. Since i...
Correction: Proteogenomic characterization of molecular and cellular targets for treatment‑resistant subtypes in locally advanced cervical cancers [0.03%]
纠正：对局部晚期宫颈癌治疗抵抗亚型的蛋白质基因组特征及细胞分子靶点分析
Do Young Hyeon,Dowoon Nam,Hye-Jin Shin et al.
Do Young Hyeon et al.
Published Erratum
Molecular cancer. 2025 Nov 29;24(1):301. DOI:10.1186/s12943-025-02522-4 2025
Downregulation of Sod2 increases atypical flat lesions and dysplasia to advance pancreatic ductal adenocarcinoma [0.03%]
Sod2下调可增加非典型性胰管上皮内病变至高级别上皮内瘤变及胰腺导管腺癌的进展风险
Alicia K Fleming Martinez,Heike R Döppler,Ryan Argo et al.
Alicia K Fleming Martinez et al.
Background: Production of mitochondrial reactive oxygen species (mROS) induces acinar-to-ductal metaplasia (ADM), an initiating step towards pancreatic ductal adenocarcinoma (PDAC). Manganese superoxide dismutase (SOD2, M...
Retraction Note: Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26+ cancer stem cells in colorectal carcinoma [0.03%]
撤回 notice: 雷帕霉素哺乳动物靶蛋白抑制剂对结直肠癌细胞和结肠癌 cd26+ 癌症干细胞抗肿瘤和抗转移效果的临床前分析
Ariel Km Chow,Nathan Sm Cheng,Colin Sc Lam et al.
Ariel Km Chow et al.