Editorial expression of concern: Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer [0.03%]
社论关注：大豆异黄酮通过表观遗传活化雌激素受体-α增强激素治疗在雌激素受体阴性乳腺癌中的敏感性发表表达担忧
Yuanyuan Li,Syed M Meeran,Shweta N Patel et al.
Yuanyuan Li et al.
Advances in improving cancer immunotherapy with nanotechnology: from smart nanoparticles to synergistic combination strategies [0.03%]
纳米技术改善癌症免疫治疗的研究进展：从智能型纳米颗粒到协同组合策略研究
Untack Cho,Jingjing Pu,Amit Sharma et al.
Untack Cho et al.
Cancer immunotherapy has substantially advanced cancer treatment, achieving durable responses in select malignancies. However, its widespread application is limited by significant challenges: low efficacy in many solid tumors, severe side e...
Radiotherapy and tertiary lymphoid structures: balancing immune activation and immune damage in cancer immunotherapy [0.03%]
放疗和三级淋巴器官结构：癌症免疫治疗中的免疫激活与免疫损伤之间的平衡关系
Yi Zhang,Hongshuai Li,Siyao Lv et al.
Yi Zhang et al.
Cancer immunotherapy, exemplified by immune checkpoint blockade (ICB), remains strongly influenced by the pre-existing immune organization of the tumor microenvironment. Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates wh...
Spatial proteomics reveals four-stage molecular evolution in cancer immunotherapy-related gastritis [0.03%]
空间蛋白质组学揭示了与癌症免疫治疗相关的胃炎的四阶段分子演化
Lei Shi,Zhongqiao Lin,Huishan Zhang et al.
Lei Shi et al.
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet immune-related adverse events (irAEs) including immunotherapy-related gastritis (IRAEG) pose significant clinical challenges-often nec...
Evidence of endothelial anergy and T-cell exclusion in microsatellite stable colorectal liver metastases revealed through human hemi-liver perfusion and spatial transcriptomics [0.03%]
通过人类半肝灌注和空间转录组学揭示微卫星稳定型结直肠癌肝转移中内皮细胞无应答及T细胞排挤现象的证据
Peter Kok-Ting Wan,Ranchu Cheng,David Johnson et al.
Peter Kok-Ting Wan et al.
Background: Colorectal liver metastasis (CRLM) is the terminal stage of colorectal cancer and remains largely resistant to immunotherapeutics, yet the underlying immune escape mechanisms remain poorly understood. Through ...
RNA modifications in cancer: regulators of tumor evolution and therapeutic response [0.03%]
癌症中的RNA修饰：肿瘤进化和治疗反应的调节因素
Xinyu Gu,Yuting He,Ziyi Xu et al.
Xinyu Gu et al.
RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I) editing, constitute a dynamic epitranscriptomic network th...
ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer [0.03%]
ADSL通过促进富马酸诱导的scrib-rictor复合物形成来促进三阴性乳腺癌转移扩散
Yidan Fan,Xiaofang He,Wei Deng et al.
Yidan Fan et al.
Background: Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior and limited therapeutic options. Although metabolic reprogramming is increasingly recognized as a hallmark of TNBC, the m...
Protein lactylation in cancer: principles, programmes and therapeutic opportunities [0.03%]
蛋白质乳酰化在癌症中的作用：原理、程序和治疗机会
Xiaoyun Bu,Xinyue Yu,Jie Wang et al.
Xiaoyun Bu et al.
Lactylation is a recently identified metabolism-associated post-translational modification that provides a mechanistic link between tumor metabolic reprogramming and epigenetic regulation. Although aberrant lactate accumulation in tumor tis...
Breaking barriers: nano-boosted drug delivery systems in overcoming the defenses of pancreatic cancer [0.03%]
突破屏障：纳米增强型药物递送系统克服胰腺癌防御体系的挑战
Yujia Wang,Yuxin Zhang,Xueyan Wang et al.
Yujia Wang et al.
Pancreatic cancer (PC) remains a highly lethal malignancy presenting formidable therapeutic challenges, primarily attributable to the substantial barriers posed by its dense desmoplastic stroma, profoundly immunosuppressive microenvironment...
Correction: CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma [0.03%]
订正：CHEK1和circCHEK1_246aa诱发多发性骨髓瘤染色体不稳定并诱导骨病灶形成
Chunyan Gu,Wang Wang,Xiaozhu Tang et al.
Chunyan Gu et al.
Published Erratum
Molecular cancer. 2026 Jul 17;25(1):179. DOI:10.1186/s12943-026-02734-2 2026