An immune responsive tumor microenvironment imprints into PBMCs and predicts outcome in advanced pancreatic cancer: lessons from the PREDICT trial [0.03%]
一项关于晚期胰腺癌的免疫响应性肿瘤微环境印记到外周血单个核细胞并预测预后：PREDICT试验的经验教训
Anton Lahusen,Manfred P Lutz,Rui Fang et al.
Anton Lahusen et al.
Background: Prognosis in advanced pancreatic ductal adenocarcinoma (aPDAC) is particularly poor, only few patients benefit from treatment, and there are few biomarkers. The PREDICT trial examined whether first-line time-t...
Clinical Trial
Molecular cancer. 2025 Jul 22;24(1):202. DOI:10.1186/s12943-025-02406-7 2025
Primary and secondary metastatic dissemination: multiple routes to cancer-related death [0.03%]
原发和继发性转移扩散：癌症相关死亡的多种途径
D Sparrer,R Blazquez,F Keil et al.
D Sparrer et al.
Metastatic disease accounts for approximately 80% of cancer-related deaths, typically manifesting as single-organ failure mainly through abdominal, cardiovascular, neurological, or respiratory complications. Despite treating thousands of ca...
NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis [0.03%]
NSUN2介导的FSP1第5位胞嘧啶甲基化保护急性髓系白血病细胞免受铁死亡侵害
Wenle Ye,Yanchun Zhao,Yutong Zhou et al.
Wenle Ye et al.
RNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in...
Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment [0.03%]
光动力药物活化技术联合光动力疗法在肿瘤治疗中的应用研究进展
Yining Du,Jingyuan Zhao,Shuai Li et al.
Yining Du et al.
The design of prodrugs aims to address the issues of systemic toxicity and poor specificity associated with traditional chemotherapy drugs, thereby improving patient survival rates. However, effectively controlling the activation of prodrug...
From preneoplastic lesion to heterogenous tumor: recent insights into hepatoblastoma biology and therapeutic opportunities [0.03%]
从癌前病变到异质性肿瘤：肝母细胞瘤生物学和治疗机会的最新见解
Jun Yang,Andrew M Davidoff,Andrew J Murphy
Jun Yang
Hepatoblastoma is the most common pediatric liver cancer, with the fastest rising incidence among childhood malignancies. Early genomic studies revealed that hepatoblastoma has the lowest mutational burden of any human cancer, however, rece...
CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA [0.03%]
Circular RNA CircABCA1通过IGF2BP3介导的SCARB1 mRNA稳定促进胆固醇代谢重编程和辅助M2型巨噬细胞极化从而促进ccRCC的发展
Hao Ning,Yan Jiang,Binbin Li et al.
Hao Ning et al.
Background: The reliance of clear cell renal cell carcinoma (ccRCC) on exogenous cholesterol import implies a metabolic susceptibility. This susceptibility represents a potential avenue that can be exploited as a novel th...
Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24 [0.03%]
活性NRF2肺鳞状细胞癌对NRF2和TRIM24的双重敏感性
Miriam Sánchez-Ortega,Antonio Garrido,Lorena Sanz et al.
Miriam Sánchez-Ortega et al.
Asra Khan,Mengqiu Song,Zigang Dong
Asra Khan
The tumor microbiome in cancer progression: mechanisms and therapeutic potential [0.03%]
肿瘤微生物组与癌症进展：机制和治疗潜力
Wanting Zhang,Yuhang Xiang,He Ren et al.
Wanting Zhang et al.
The tumor microbiome (TM) comprises diverse microbial communities, such as bacteria, fungi, and viruses. Recent advancements in microbial sequencing technologies have improved our understanding of the distribution and functional roles of mi...
Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development [0.03%]
肿瘤微环境的桥梁作用：癌相关成纤维细胞在肿瘤恶病质发生发展中的核心地位
Guoming Chen,Bonan Chen,Yilin Wu et al.
Guoming Chen et al.