Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics [0.03%]
细胞衰老与癌症：从机制悖论到精准治疗
Tiejun Feng,Fuda Xie,Leo M Y Lee et al.
Tiejun Feng et al.
Cellular senescence is a double-edged sword in cancer biology, functioning as both a tumor-suppressive mechanism and a driver of malignancy. Initially, senescence acts as a protective barrier by arresting the proliferation of damaged or onc...
Lin Shui,Dan Wu,Kaixuan Yang et al.
Lin Shui et al.
Advancements in diagnostic and therapeutic standards have substantially enhanced the survival of patients with malignant tumors. Nevertheless, the quest for effective strategies to address resistant or recurrent advanced tumors remains a cr...
Christabelle Rajesh,Richard D Cummings,Prakash Radhakrishnan
Christabelle Rajesh
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease, and standard of care therapies have failed to yield significant clinical benefit, with invasive surgery being the only curative treatment for patients with early-st...
Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy [0.03%]
免疫细胞重编程中的代谢检查点——用于癌症治疗的免疫代谢重塑
Yingying Lv,Zongshang Li,Shutong Liu et al.
Yingying Lv et al.
Immune cell metabolism plays a pivotal role in regulating cellular proliferation, differentiation, and functional responses, collectively shaping immune responses within the tumor microenvironment (TME). Recent advancements increasingly hig...
Peng Song,Tongtong Liu,Yinfang Zhang et al.
Peng Song et al.
Breast cancer (BC) is the most commonly diagnosed malignancy among women globally. While treatments such as chemotherapy and endocrine therapy have contributed to improving survival rates, there remains a critical need for more effective th...
Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma [0.03%]
靶向FGFR4可消除胰腺导管腺癌中HNF1A驱动的转移性病变
Katherine J Crawford,Kennedy S Humphrey,Eduardo Cortes et al.
Katherine J Crawford et al.
Background: We previously identified an oncogenic role for the transcription factor HNF1A in pancreatic ductal adenocarcinoma (PDAC). However, the role of HNF1A in the metastatic progression of PDAC remains unknown and ta...
Advances and obstacles of T cell-based immunotherapy in gynecological malignancies [0.03%]
基于T细胞免疫治疗妇科恶性肿瘤的进展与挑战
Xi Zhao,Jialing Ran,Shenglong Li et al.
Xi Zhao et al.
T cell-mediated immunotherapy has revolutionized oncology by enabling precision immune responses against malignant cells. Chimeric Antigen Receptor (CAR) T-cell therapy, which involves genetically reprogramming T lymphocytes to recognize tu...
Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers [0.03%]
抢占稳态：肿瘤发病中脑-体神经环路及新兴疗法前沿
Yong-Fei Wang,Zi-Kai Dong,Wei-Lin Jin
Yong-Fei Wang
Cancer research is undergoing a paradigm shift from solely studying tumor cells to investigating systemic effects of cancer in the tumor macroevironment, with an emphasis on the interactions between host organs and tumors. The theory of hom...
PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy [0.03%]
聚乙二醇化PLGA纳米颗粒：解锁癌症治疗的先进策略
Prashant Kesharwani,Vishal Kumar,Khang Wen Goh et al.
Prashant Kesharwani et al.
Poly(lactic-co-glycolic acid) (PLGA) is a widely utilized biodegradable and biocompatible polymer in drug delivery systems, particularly for encapsulating drug molecules with poor solubility and permeability. PLGA nanoparticles, composed of...
Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation [0.03%]
代谢重新编程通过CASP3乳酸化促进急性淋巴细胞白血病的抗凋亡作用
Zhi Lin,Fei Long,Jiao Liu et al.
Zhi Lin et al.