Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment [0.03%]
单细胞多组学在癌症免疫治疗中的应用：从肿瘤异质性到个性化精准治疗
Jiayuan Le,Yating Dian,Deze Zhao et al.
Jiayuan Le et al.
Cancer immunotherapy has revolutionized clinical oncology; however, the inherent complexity and heterogeneity of cancer present substantial challenges to achieving broad therapeutic efficacy. Tumor heterogeneity manifests not only among dif...
The application of organoids in treatment decision-making for digestive system cancers: progress and challenges [0.03%]
类器官在消化系统肿瘤治疗决策中的应用：进展与挑战
Yufei Wang,Limin Zhang,Louis Zizhao Wang et al.
Yufei Wang et al.
Digestive system cancers-including gastric, liver, colorectal, esophageal, and pancreatic malignancies-remain leading causes of cancer death, with treatment resistance posing major challenges in advanced disease. Patient-derived cancer orga...
Retraction Note: m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling [0.03%]
撤回 notice:通过降低WIF-1RNA甲基化和介导Wnt信号传导来抑制胰腺癌的发生发展的m6A去甲基酶ALKBH5的撤回通知
Min Kang,Yunshan Wang,Yan Wang et al.
Min Kang et al.
Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities [0.03%]
生物分子相分离与肿瘤发生：从异常凝聚体到治疗靶点
Lan Hu,Zikun Huang,Zhaoyong Liu et al.
Lan Hu et al.
Biomolecular phase separation has emerged as a fundamental mechanism governing intracellular spatial organization and functional compartmentalization, and is increasingly recognized as a critical factor in tumor initiation and progression. ...
Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers [0.03%]
氧化应激与肿瘤发生发展及创新治疗研究进展
Xisong Liang,Jiadi Weng,Zhongyi You et al.
Xisong Liang et al.
Oxidative stress is a pathological condition of redox signaling dysregulation and macromolecular oxidative damage arising from elevated ROS levels. Oxidative stress interacts with tumor cell growth regulation and tumor microenvironment remo...
CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation [0.03%]
Circular RNA CircZFR通过YTHDF3/FASN轴促进宫颈癌淋巴结转移
Mingyi Zhou,Yan Gao,Yong Zhang et al.
Mingyi Zhou et al.
Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear. ...
Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer [0.03%]
Jab1通过调节HRR信使rna稳定性来调控三阴性乳腺癌的PARP抑制剂敏感性
Xin Peng,Yingying Wang,Zixiang Yu et al.
Xin Peng et al.
Background: Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype associated with the highest mortality rate among all breast cancer subtypes, primarily due to the absence of actionable therape...
Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors [0.03%]
神经递质：肿瘤免疫检查点抑制剂获得性抵抗的新兴治疗靶标
Jiyuan Yang,Yu Wu,Xinhui Lv et al.
Jiyuan Yang et al.
The critical role of neurotransmitters in the resistance to tumor immune checkpoint inhibitor (ICI) is becoming increasingly significant in therapeutic contexts. ICIs work by enhancing antitumor immunity through the blockade of the PD-1/PD-...
Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors [0.03%]
神经科学和肿瘤学的融合：消化系统肿瘤发生及发展的神经免疫交互作用
Haonan Sun,Tao Wang,Xiangyan Jiang et al.
Haonan Sun et al.
CircRNA aptamer targets IGF2BP2 to overcome acquired BETi resistance [0.03%]
环状circRNA适配体靶向IGF2BP2以克服获得性BETi耐药性
Christophe Nicot
Christophe Nicot