HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4-ERK1/2-U2AF2-TFRC axis [0.03%]
HPGD通过LXA4-ERK1/2-U2AF2-TFRC轴诱导铁死亡和自噬来抑制食管鳞状细胞癌
Tianyun Ma,Xiamei Guo,Jueying Zhao et al.
Tianyun Ma et al.
Background: Although 15-hydroxyprostaglandin dehydrogenase (HPGD) is known to regulate the metabolism of prostaglandins and lipoxin A4, and its dysregulation has been implicated in various cancers, its role in esophageal ...
HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4-ERK1/2-U2AF2-TFRC axis [0.03%]
HPGD通过LXA4-ERK1/2-U2AF2-TFRC轴诱导铁死亡和自噬来抑制食管鳞状细胞癌
Tianyun Ma,Xiamei Guo,Jueying Zhao et al.
Tianyun Ma et al.
The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets [0.03%]
乙酰胆碱及其受体在肿瘤免疫调节中的作用：机制和潜在治疗靶点
Chunyu Zhang,Xiangdong Guo,Yanan Wang et al.
Chunyu Zhang et al.
Acetylcholine (ACh) is an essential neurotransmitter that has recently gained attention for its multifunctional role in tumor immune regulation. By binding neuronal loss to nicotinic and muscarinic receptors, ACh directly promotes tumor cel...
Epigenetic modification of cuproptosis by non-coding RNAs in cancer drug resistance [0.03%]
非编码RNA通过表观遗传修饰调控铜死亡抵抗肿瘤药物作用
Fei Du,Lu Tang,Fang Wang et al.
Fei Du et al.
Tumor drug resistance remains a significant barrier to effective cancer treatment, undermining the clinical efficacy of current therapies through adaptive and evolving mechanisms. Cuproptosis, a recently discovered form of programmed cell d...
Evolution of direct RAS inhibitors: from undruggable target to clinical breakthroughs [0.03%]
直接RAS抑制剂的发展：从不可成药靶点到临床突破
Xia Wang,Jing Wu,Aotian Xiao et al.
Xia Wang et al.
The RAS signaling pathway, particularly through mutations in KRAS, NRAS, and HRAS, plays a pivotal role in driving oncogenesis in a wide range of cancers. For years, RAS proteins were deemed "undruggable" due to their smooth surface and lac...
Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer [0.03%]
多功能金纳米颗粒在癌症检测、诊断及治疗中的应用
Lianting Zhuang,Yi Lian,Tiantong Zhu
Lianting Zhuang
Cancer remains a leading global health challenge, responsible for millions of deaths annually. Conventional therapies are hindered by systemic toxicity, drug resistance, and ineffective targeting of the tumor microenvironment (TME). Gold na...
Retraction Note: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer [0.03%]
撤回 notice:长链非编码rna PVT1通过调节miR-143/HK2轴促进胆囊癌进展
Jianan Chen,Yan Yu,Hua Li et al.
Jianan Chen et al.
Correction: Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development [0.03%]
纠正：肿瘤微环境的连接：癌相关成纤维细胞在肿瘤恶病质发展中的关键作用
Guoming Chen,Bonan Chen,Yilin Wu et al.
Guoming Chen et al.
Published Erratum
Molecular cancer. 2025 Sep 4;24(1):226. DOI:10.1186/s12943-025-02453-0 2025
Engineered iron oxide nanoplatforms: reprogramming immunosuppressive niches for precision cancer theranostics [0.03%]
工程化铁氧纳米平台：重塑免疫抑制微环境用于癌症精确诊断与治疗
Chao Yang,Shenglong Li,Liming Wang
Chao Yang
Iron oxide nanoparticles (IONPs) have transitioned from conventional magnetic resonance imaging (MRI) contrast agents into structurally programmable combined imaging/treatment tools, leveraging their superparamagnetism, catalytic activity, ...
Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis [0.03%]
乳腺癌新型细胞死亡机制研究进展：铁死亡、铜死亡、二硫化物型细胞死亡和焦亡的交叉视角
Zhengjun Jing,Wenqin Huang,Jun Mei et al.
Zhengjun Jing et al.
The advent of molecular classification has ushered breast cancer treatment into the era of precision medicine. Nevertheless, clinical management continues to face significant challenges posed by drug resistance and tumor heterogeneity. Rece...