The immune microenvironment of pathogen-associated cancers and current clinical therapeutics [0.03%]
病原体相关癌症的免疫微环境和当前临床治疗方案
Xiao-Yu Wei,Hui-Jing Feng,Ying-Yin Zhu et al.
Xiao-Yu Wei et al.
Pathogen-associated cancers account roughly 15-20% of all malignancies worldwide and arise from chronic infections by oncogenic viruses, bacteria and parasites. Pathogens can alter the tumor microenvironment (TME) into an immune-suppressive...
The immune microenvironment of pathogen-associated cancers and current clinical therapeutics [0.03%]
病原体相关癌症的免疫微环境及当前临床治疗手段
Xiao-Yu Wei,Hui-Jing Feng,Ying-Yin Zhu et al.
Xiao-Yu Wei et al.
Pathogen-associated cancers account roughly 15-20% of all malignancies worldwide and arise from chronic infections by oncogenic viruses, bacteria and parasites. Pathogens can alter the tumor microenvironment (TME) into an immune-suppressive...
Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer [0.03%]
泛素信号网络的调控机制及其在精确放射增敏治疗中的应用研究
Fu-Ying Zhao,Li-Ye Shi,Lu-Jiao Yu et al.
Fu-Ying Zhao et al.
Radiotherapy resistance remains a major clinical challenge, largely driven by tumors' ability to dynamically adapt through complex molecular networks. Critically, the ubiquitin system has emerged as a critical regulator of this resistance. ...
Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer [0.03%]
泛素信号网络的调控机制及精确放射增敏的肿瘤治疗新策略研究
Fu-Ying Zhao,Li-Ye Shi,Lu-Jiao Yu et al.
Fu-Ying Zhao et al.
Radiotherapy resistance remains a major clinical challenge, largely driven by tumors' ability to dynamically adapt through complex molecular networks. Critically, the ubiquitin system has emerged as a critical regulator of this resistance. ...
Microbiome-metabolome interplay in pancreatic cancer progression: insights from multi-omics analysis [0.03%]
胰腺癌进展中的微生物组-代谢组相互作用：多组学分析的新见解
Dong Luo,Qizhen Chen,Yixiong Li et al.
Dong Luo et al.
Background: Recent studies suggest that intratumoral microbiome and altered metabolic networks play crucial roles in pancreatic cancer (PC) progression. However, the precise interplay between microbial communities and tum...
Microbiome-metabolome interplay in pancreatic cancer progression: insights from multi-omics analysis [0.03%]
胰腺癌进展中微生物组-代谢组互作的多组学分析初探
Dong Luo,Qizhen Chen,Yixiong Li et al.
Dong Luo et al.
Background: Recent studies suggest that intratumoral microbiome and altered metabolic networks play crucial roles in pancreatic cancer (PC) progression. However, the precise interplay between microbial communities and tum...
Lipid reprogramming and ferroptosis crosstalk in clear cell renal cell carcinoma: metabolic vulnerabilities and therapeutic targeting [0.03%]
透明细胞肾细胞癌中的脂质重构与铁死亡互作：代谢弱点和靶向治疗
Qing Deng,Yu Ji,Jian Liu et al.
Qing Deng et al.
Clear cell renal cell carcinoma (ccRCC) features metabolic dysregulation, with altered lipid metabolism and ferroptosis dysregulation driving malignancy. This review examines the interplay between lipid reprogramming and ferroptosis resista...
Lipid reprogramming and ferroptosis crosstalk in clear cell renal cell carcinoma: metabolic vulnerabilities and therapeutic targeting [0.03%]
脂质重组与铁死亡串扰在透明细胞肾癌中的作用：代谢弱点和治疗靶向
Qing Deng,Yu Ji,Jian Liu et al.
Qing Deng et al.
Clear cell renal cell carcinoma (ccRCC) features metabolic dysregulation, with altered lipid metabolism and ferroptosis dysregulation driving malignancy. This review examines the interplay between lipid reprogramming and ferroptosis resista...
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer [0.03%]
BRD9-p53-E2F1通路调控胃癌的细胞生长和DNA损伤修复
Qingqing Zhou,Qi Wang,Yantao Duan et al.
Qingqing Zhou et al.
Background: BRD9 is involved in multiple physiological and pathological pathways, yet its functional role and molecular mechanisms in gastric cancer (GC) remain largely unexplored. Addressing this knowledge gap is critica...
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer [0.03%]
BRD9-p53-E2F1信号轴调控胃癌的细胞增殖和DNA损伤修复功能
Qingqing Zhou,Qi Wang,Yantao Duan et al.
Qingqing Zhou et al.
Background: BRD9 is involved in multiple physiological and pathological pathways, yet its functional role and molecular mechanisms in gastric cancer (GC) remain largely unexplored. Addressing this knowledge gap is critica...