Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy [0.03%]
癌症中的Wnt/β-连环蛋白介导的信号转导通路：最新进展及在癌症治疗中的应用
Xiuzhu Wu,Haiying Que,Qingfang Li et al.
Xiuzhu Wu et al.
The Wnt/β-catenin signaling pathway is a highly conserved signaling pathway closely linked to cancer development through various biological processes, including oncogenic transformation, genomic instability, cancer cell proliferation, stem...
CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation [0.03%]
CREPT通过合作型染色质环介导的基因调控促进三阴性乳腺癌转移
Jianghua Li,Lu Xu,Jiayu Wang et al.
Jianghua Li et al.
Triple-negative breast cancer (TNBC) is recognized for its aggressiveness, yet the mechanism underlying metastasis remains unclear. Here, we report that CREPT/RPRD1B, which exhibits somatic gene copy-number amplifications and elevated expre...
Differential susceptibility and role for senescence in CART cells based on costimulatory domains [0.03%]
CART细胞基于共刺激结构域的差异敏感性和衰老的作用
Ismail Can,Elizabeth L Siegler,Olivia L Sirpilla et al.
Ismail Can et al.
Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy....
The tumor microenvironment in hepatocellular carcinoma: mechanistic insights and therapeutic potential of traditional Chinese medicine [0.03%]
传统中药在肝细胞癌肿瘤微环境中的机制研究和治疗潜力
Xiaojun Su,Xiuli Yan,Hui Zhang
Xiaojun Su
Hepatocellular carcinoma (HCC) progression and therapeutic resistance are profoundly influenced by the dynamic interplay within the tumor microenvironment (TME). The HCC TME comprises a complex network of cellular components, including canc...
Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside [0.03%]
纳米医学在癌症治疗中的应用：从实验台到临床的当前视角
K M Abdullah,Gunjan Sharma,Ajay P Singh et al.
K M Abdullah et al.
Cancer is among the leading causes of death worldwide, with projections indicating that it will claim 35 million lives by the year 2050. Conventional therapies, such as chemotherapy and immune modulation, have reduced cancer mortality to so...
Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 [0.03%]
上皮-间质转化（EMT）与癌症转移：方法和实验模型的现状与未来展望（2025年）
Heike Allgayer,Samikshya Mahapatra,Barnalee Mishra et al.
Heike Allgayer et al.
Epithelial-to-mesenchymal transition (EMT) is a crucial cellular process for embryogenesis, wound healing, and cancer progression. It involves a shift in cell interactions, leading to the detachment of epithelial cells and activation of gen...
Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis [0.03%]
靶向PERP通过调节肿瘤免疫微环境和代谢稳态促进头颈鳞癌的抗肿瘤免疫
Xueying Wang,Yuxi Tian,Xiaohong Wu et al.
Xueying Wang et al.
Background: PERP may have the potential to function as an oncogene. However, the precise function, prognostic value, and predictive significance remain shrouded in ambiguity. ...
Integrative multi-omics analysis reveals the LncRNA 60967.1-PLCD4-ATRA axis as a key regulator of colorectal cancer progression and immune response [0.03%]
整合多组学分析揭示长链非编码RNA 60967.1-PLCD4-ATRA轴在结直肠癌进展和免疫反应中的关键调控作用
Yiyi Chen,Ningning Zhao,Lingna Xu et al.
Yiyi Chen et al.
Colorectal cancer (CRC) is a major global health concern, characterized by high morbidity and mortality rates. CRC progression involves intricate molecular networks that remain incompletely understood. In this study, we conducted an integra...
Exosomes in cancer nanomedicine: biotechnological advancements and innovations [0.03%]
癌症纳米医学中的外泌体：生物技术的进步与创新
Jacky J J Liu,Duanrui Liu,Sally K Y To et al.
Jacky J J Liu et al.
Exosomes, as natural intercellular messengers, are gaining prominence as delivery vehicles in nanomedicine, offering a superior alternative to conventional synthetic nanoparticles for cancer therapeutics. Unlike lipid, polymer, or metal...
The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism [0.03%]
EGR1介导的长链非编码RNA TENM3-AS1通过重新编程脂肪酸代谢促进胃癌转移
Yuhui Tang,Baiwei Zhao,Wanchuan Wang et al.
Yuhui Tang et al.
Background: Long non-coding RNAs (lncRNAs) are essential modulators in tumor progression. While fatty acid (FA) metabolism can potentiate tumorigenesis, colonization, and metastasis, the roles of lncRNAs in reprograming F...