Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity [0.03%]
差异表达的Nedd4结合蛋白Ndfip1能保护神经元抵抗甲基苯丙胺引起的神经毒性
Masato Asanuma,Ikuko Miyazaki,Jean Lud Cadet
Masato Asanuma
To identify factors involved in methamphetamine (METH) neurotoxicity, we comprehensively searched for genes which were differentially expressed in mouse striatum after METH administration using differential display (DD) reverse transcriptio...
Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis [0.03%]
姜黄素改善海马细胞生物能量、氧化还原和炎症标志物以及突触蛋白，调节线粒体钙稳态
Claudia Jara,Angie K Torres,Han S Park-Kang et al.
Claudia Jara et al.
Mitochondria produces energy through oxidative phosphorylation (OXPHOS), maintaining calcium homeostasis, survival/death cell signaling mechanisms, and redox balance. These mitochondrial functions are especially critical for neurons. The hi...
Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice [0.03%]
cannabigerol可减轻卤operidol诱导的小鼠空嚼运动
R Ponciano,J E C Hallak,J A Crippa et al.
R Ponciano et al.
Chronic use of typical antipsychotics can lead to varying motor effects depending on the timing of analysis. Acute treatment typically induces hypokinesia, resembling parkinsonism, while repeated use can result in tardive dyskinesia, a hype...
Implication of Pyrethroid Neurotoxicity for Human Health: A Lesson from Animal Models [0.03%]
拟除虫菊酯神经毒性的公共卫生意义——来自动物模型的启示
Mega Obukohwo Oyovwi,Adedeji David Atere,Paul Chimwuba et al.
Mega Obukohwo Oyovwi et al.
Pyrethroids, synthetic insecticides used in pest management, pose health risks, particularly neurotoxic effects, with studies linking exposure to a neurodegenerative disorder. This review examines the neurotoxic mechanisms of pyrethroids an...
No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage [0.03%]
实验性脑内出血后3%高渗盐水治疗无益
Tiffany F C Kung,Anna C J Kalisvaart,Angely Claire C Suerte et al.
Tiffany F C Kung et al.
Intracerebral hemorrhage (ICH) is a stroke subtype with a high mortality rate (~ 40%). After ICH, the mass effect of the hematoma and edema contribute to raised intracranial pressure (ICP) and poor outcome. Endogenous compensatory mechanism...
Jan L Cheng,Anthony L Cook,Jana Talbot et al.
Jan L Cheng et al.
Excitotoxicity linked either to environmental causes (pesticide and cyanotoxin exposure), excitatory neurotransmitter imbalance, or to intrinsic neuronal hyperexcitability, is a pathological mechanism central to neurodegeneration in amyotro...
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses [0.03%]
5-脂氧合酶缺乏对多巴胺介导的行为反应的影响
Ana Carolina Issy,João Francisco Pedrazzi,Glauce Crivelaro Nascimento et al.
Ana Carolina Issy et al.
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central nervous system. Understanding how this system interacts with the dopaminergic system could provide valuable insights ...
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication [0.03%]
沙林中毒后乙酰胆碱酯酶人源化小鼠癫痫模型中腺苷A1受体激动剂的作用机制研究
Tsung-Ming Shih,Crystal Munoz,Cindy Acon-Chen et al.
Tsung-Ming Shih et al.
Recently a novel genetically modified mouse strain with serum carboxylesterase knocked-out and the human acetylcholinesterase gene knocked-in (KIKO) was created to simulate human responses to nerve agent (NA) exposure and its standard medic...
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum [0.03%]
维生素C对味精诱导的大鼠纹状体和小脑氧化应激的影响及其对ATP酶活性的作用
Olusegun L Adebayo,Vivian A Agu,Grace A Idowu et al.
Olusegun L Adebayo et al.
Monosodium glutamate (MSG) is a silent excitotoxin used as a flavour enhancer but exerts serious health hazards to consumers. MSG plays a role in neuronal function as the dominant excitatory neurotransmitter. It is transferred into the bloo...
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum [0.03%]
神经发育期间暴露于利他林会改变大鼠纹状体中的氨基酸谱系，星形胶质细胞标志物和谷氨酸能兴奋毒性
Felipe Schmitz,Luz Elena Durán-Carabali,Alessandra Schmitt Rieder et al.
Felipe Schmitz et al.
There is a public health concern about the use of methylphenidate (MPH) since the higher prescription for young individuals and non-clinical purposes is addressed to the limited understanding of its neurochemical and psychiatric consequence...