Prenatal Coca Paste Exposure Impairs Hippocampal Neuronal Development and Recognition Memory in Offspring [0.03%]
孕期古柯膏暴露损害子代海马神经元发育和识别记忆
Vanina Clouzet,Alberto Rafael,Andrea Cairus et al.
Vanina Clouzet et al.
Illicit psychostimulant use during pregnancy represents a major public health issue due to its detrimental effects on offspring neurodevelopment. Prenatal exposure to smokable cocaine derivatives such as crack cocaine and coca paste (CP) is...
Evaluation of an Integrated In Silico-In Vitro Pipeline for Predicting Mitochondrial Complex I-Mediated Neurotoxicity of Chlorpyrifos [0.03%]
基于氯毗杀螨酯的线粒体复合物I介导的神经毒性的“从计算机到实验”的预测管道评估
Fuat Karakuş,Muhammed Tilahun Muhammed,Ege Arzuk
Fuat Karakuş
Chlorpyrifos (CPF) is a broad-spectrum chlorinated organophosphate insecticide. It was classified as a persistent organic pollutant under the Stockholm Convention in 2024 due to its harmful effects on the environment and human health, inclu...
Inhibition of Glutamate Decarboxylase in the Spinal Cord Induces Motor Deficits and Motor Neuron Degeneration [0.03%]
脊髓谷氨酸脱羧酶活性抑制引起运动功能障碍和运动神经元变性
Elizabeth Colín-Martínez,Uri Nimrod Ramírez-Jarquín,Ricardo Tapia et al.
Elizabeth Colín-Martínez et al.
Motor neuron (MN) diseases such as amyotrophic lateral sclerosis (ALS) are characterized by the loss of cortical and spinal MNs. Although the precise mechanisms of MN degeneration are still unknown, downregulation of GABAergic circuits has ...
Correction to: C-terminal Domain of the Heavy Chain of Tetanus Toxin Ameliorate Lipopolysaccharide Induced Hemiparkinsonism in Rats [0.03%]
Correction to：破伤风毒素重链C端结构域改善脂多糖诱导的大鼠半侧帕金森病症状
Irving Parra,José Aguilera,Yousef Tizabi et al.
Irving Parra et al.
Published Erratum
Neurotoxicity research. 2026 Jul 29;44(4):39. DOI:10.1007/s12640-026-00814-1 2026
Melatonin Modulates Behavioral and Physiological Responses in a Concentration-dependent Manner in a Pilocarpine-induced Seizure-like Model Using Zebrafish Larvae [0.03%]
褪黑素以浓度依赖性方式调节斑马鱼癫痫样模型的行为和生理反应
Lorrânny Pereira de Assis Valadares,Bianca Leite Carnib,Bruno Dos Santos Ferreira Roque et al.
Lorrânny Pereira de Assis Valadares et al.
Melatonin has been extensively studied for its antioxidant activity, yet its safety profile and concentration-dependent effects remain only partially understood, particularly in aquatic experimental systems. Here, we investigated the effect...
Caffeic Acid Mitigates Behavioral and Biochemical Alterations in Lead-induced Neurotoxicity in Rats With Possible Involvement of TFEB [0.03%]
咖啡酸通过可能激活TFEB的作用缓解大鼠铅神经毒性引起的生化和行为异常
Pratham Gautam,Varinder Singh,Navjot Kanwar et al.
Pratham Gautam et al.
Lead (Pb) neurotoxicity is characterized by persistent cognitive and motor impairments that arise from converging disturbances in mitochondrial function, oxidative balance, and neuroinflammatory signaling. Increasing evidence suggests that ...
C-terminal Domain of the Heavy Chain of Tetanus Toxin Ameliorate Lipopolysaccharide Induced Hemiparkinsonism in Rats [0.03%]
破伤风毒素重链C端片段改善脂多糖诱导的帕金森病半侧黑质损害作用及机制研究
Irving Parra,José Aguilera,Yousef Tizabi et al.
Irving Parra et al.
Neuroinflammation is recognized as a central mechanism in Parkinson's disease (PD) pathogenesis. The C-terminal domain of the heavy-chain of tetanus toxin (Hc-TeTx) has shown neuroprotective effects in toxin-based PD models, but its efficac...
Human Stem Cell-Derived Neurospheroids and a Multi-Assay Strategy Provide Brain Cytotoxicity New Insights from ADB-FUBIATA Exposure [0.03%]
人诱导多能干细胞来源的神经球和多联检测试剂盒策略可为ADB-FUBIATA暴露引起的脑细胞毒性提供新见解
Uliana De Simone,Carlo Alessandro Locatelli,Francesca Caloni et al.
Uliana De Simone et al.
Synthetic cannabinoids (SCs) are chemical and inhomogeneous broad group of new psychoactive substances associated with severe toxicity and death. This study aims to characterize neurotoxicological profile of ADB-FUBIATA, third-generation in...
Oral Microbial Extracellular Vesicles as Novel Mediators of Alzheimer's Pathogenesis: A Critical Review of the Periodontal-Brain Axis [0.03%]
口腔微生物外泌体作为阿尔茨海默病新发病机制的介质：牙周-脑轴批判性综述
Seyed Ebrahim Alavi,Hasan Ebrahimi Shahmabadi,Robert M Love et al.
Seyed Ebrahim Alavi et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose origins extend beyond the brain. Chronic periodontitis has emerged as a modifiable risk factor, and extracellular vesicles (EVs) have recently been proposed as impor...
Bisphenol S-Induced Neurobehavioral Impairment Is Characterized by c-Jun Activation and Distinct Dysregulation of Nrf2 and BDNF in the Zebrafish Brain [0.03%]
双酚S通过活化c-jun诱导斑马鱼脑内Nrf2和BDNF失调及神经行为异常
Bhabani Sankar Sahoo,Prerana Sarangi,Pradyumna Kumar Sahoo et al.
Bhabani Sankar Sahoo et al.
Bisphenol S (BPS), a widely used substitute for bisphenol A (BPA), is increasingly detected in consumer products and aquatic environments, yet its neurotoxic potential remains insufficiently understood. Building on our previous findings tha...