Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin [0.03%]
NMDA受体/TRPM4接口抑制剂Brophenexin对海马神经元中NMDA受体和TRPM4活性的调节作用
Jordan Casby,Rachel K Allen,Ezequiel Marron Fernandez de Velasco et al.
Jordan Casby et al.
Excitotoxic signaling mediated by N-methyl-D-aspartate receptors (NMDARs) is inhibited by NMDAR/TRPM4 complex inhibitors such as brophenexin (BPN). We used rat hippocampal neurons grown in culture to determine the effects of BPN on NMDAR an...
Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review [0.03%]
系统性综述三种主要自闭症谱系障碍啮齿动物模型中脑源性神经营养因子(BDNF)变化状况
Marzieh Jalalian-Javadpour,Mahdi Khaledian,Hamed Moradi et al.
Marzieh Jalalian-Javadpour et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, and repetitive and aggressive behaviors. The pathophysiology of ASD still remains unclear, while the population with ASD is 1/36 in childre...
Niacin Protects iPSC-Derived Neurons from Chemotherapy-Induced Toxicity [0.03%]
烟酸保护诱导多能干细胞来源的神经元免受化疗毒性的影响
Nidaa A Ababneh,Mohammad H Gharandouq,Mohammad A Ismail et al.
Nidaa A Ababneh et al.
Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review [0.03%]
婴儿期因奶粉污染导致砷中毒的长期影响：系统性综述
Khaled Saad,Ramez M Odat,Ahmed Mansour et al.
Khaled Saad et al.
Arsenic is a prevalent and significant cause of poisoning worldwide, leading to both acute and chronic toxicity. The life-threatening nature of arsenic toxicity is evident in its link to fatal health conditions in different parts and system...
Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats [0.03%]
慢性阿托莫西汀和甲基苯丙胺给药诱导年轻大鼠海马和纹状体的改变不同
Mireya Bejarano-Coria,Diana Beciez-Flores,Juan Carlos Corona
Mireya Bejarano-Coria
IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression [0.03%]
IGF2BP1通过促进TRIM45表达来加重微胶质细胞样细胞中NLRP3炎性小体的激活和促炎症表型
Pei Wang,Yanling Huang,Qian Ma et al.
Pei Wang et al.
Cerebral ischemia-reperfusion (I/R) injury is the main cause of early complications and adverse outcomes after treatment such as myocardial infarction and acute ischemic stroke. In this study, we aimed to explore the functions of insulin li...
Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization [0.03%]
全氟和多氟化合物的神经毒性机制：网络毒理学、分子对接和孟德尔随机化综合研究
Zhuoya Jiang,Chenchen Wei,Aijun Ma
Zhuoya Jiang
Background: Observational studies have shown that exposure to per- and polyfluoroalkyl substances can lead to neurotoxicity. We focus on whether perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) affect br...
Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model [0.03%]
冬虫夏草提取物对斑马鱼吸烟模型神经退行性病变的保护作用研究
Paritosh Sharma,Dev Goyal,Muskan Thakur et al.
Paritosh Sharma et al.
Background and objectives: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neurons in specific areas of the brain, often worsened by cigarette smoke through oxidative stress and i...
Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors [0.03%]
作用于α7和α9烟碱型乙酰胆碱受体的锥形肽在化疗诱导外周神经病理性疼痛中的镇痛及抗炎作用研究
Bashir Mosayyebi,Davood Rabiei Faradonbeh,Saereh Hosseindoost et al.
Bashir Mosayyebi et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by sensory dysfunction, including allodynia and hyperalgesia. Despite its clinical significance, there are no ...
The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity [0.03%]
线粒体质量控制在线皮质毒性中的作用
Alexey A Tinkov,Hyunjin Kim,Anatoly V Skalny et al.
Alexey A Tinkov et al.
The objective of the present review is to discuss the involvement of altered mitochondrial quality control in Mn-induced neurotoxicity. Existing data demonstrate that mitochondrial autophagy (mitophagy) and brain mitochondrial unfolded prot...