Protective Effect of myo-Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish [0.03%]
肌醇对地西他滨诱导的斑马鱼胚胎神经管缺陷的保护作用
Venugopalan Rajesh,Subramani Karthi,Manni Venkatachari Kumudhavalli
Venugopalan Rajesh
Neural tube defects (NTDs) are severe congenital anomalies affecting 1-2 infants per 1000 births, and are influenced by genetic and environmental factors, with DNA hypomethylation and methylation cycle suppression being key causes. In our e...
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms [0.03%]
二甲双胍通过抗氧化机制保护人类诱导多能干细胞(hiPSC)衍生的神经元免受氧化损伤
Mohammad H Gharandouq,Mohammad A Ismail,Tareq Saleh et al.
Mohammad H Gharandouq et al.
The antidiabetic drug metformin possesses antioxidant and cell protective effects including in neuronal cells, suggesting its potential use for treating neurodegenerative diseases. This study aimed to assess metformin's effects on viability...
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride [0.03%]
氯三甲基锡大鼠海马的多组学分析
Douaa Zakaria,Tomoki Yamashita,Yohei Kosugi
Douaa Zakaria
Trimethyltin chloride (TMT) is a neurotoxicant that damages the central nervous system (CNS) and triggers neurodegeneration. This study used multi-omic data, including transcriptomics and proteomics of the rat hippocampus, to identify diffe...
Evaluation of the Memory Enhancement Effects of Aminopyrimidine Derivatives Using the Scopolamine Model of Dementia in Mice [0.03%]
使用小鼠东莨菪碱痴呆模型评估氨基嘧啶衍生物的记忆改善作用
Behnaz Landi,Mona Khoramjouy,Alireza Ghavami Lahij et al.
Behnaz Landi et al.
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence as multi-targeted molecules. This makes them perfect candidates as agents for cognitive improvement, as cognitive dec...
The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model [0.03%]
奈林对肥胖大鼠模型海马认知行为功能，CREB / BDNF 信号传导，胆碱能活性和神经元密度的影响
Bahareh Alijani,Mohammad Amin Edalatmanesh,Heydar Aghababa
Bahareh Alijani
The global rise in obesity and overweight over the past few decades has led to numerous associated disorders, including cognitive deficits. This study evaluate investigates the effects of Naringin (Nar) on memory and learning, anxiety-like ...
Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving [0.03%]
由于不利的照顾导致早期生活压力的大鼠模型中的性别特异性结果
Jazmín Grillo Balboa,Ailén A Colapietro,Verónica I Cantarelli et al.
Jazmín Grillo Balboa et al.
Early parental care is critical for the development of cortico-limbic circuits regulating stress responses and emotional well-being. Conversely, infant maltreatment can increase susceptibility to mood disorders-such as anxiety and depressio...
Restoration of MPTP-induced Dopamine and Tyrosine Hydroxylase Depletion in the Mouse Brain Through Ethanol and Nicotine [0.03%]
乙醇和尼古丁对MPTP诱导的小鼠脑多巴胺及酪氨酸羟化酶缺乏的恢复作用
Mostofa Jamal,Sella Takei,Ikuko Tsukamoto et al.
Mostofa Jamal et al.
Dopamine (DA) has long been considered a major factor in the development of Parkinson's disease (PD). Ethanol (EtOH) and nicotine (Nic), either alone or in combination, have been shown to affect nigrostriatal dopaminergic neuronal activity....
Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway [0.03%]
白藜芦醇的胶质细胞保护作用及其对谷氨酸诱导的细胞功能障碍中血红素氧合酶1通路的影响作用研究
André Quincozes-Santos,Larissa Daniele Bobermin,Ana Carolina Tramontina et al.
André Quincozes-Santos et al.
Resveratrol, a natural polyphenol, has shown promising neuroprotective effects in several in vivo and in vitro experimental models. However, the mechanisms by which resveratrol mediates these effects are not fully understood. Glutamate is t...
Correction to: Dexmedetomidine Promoted HSPB8 Expression via Inhibiting the lncRNA SNHG14/UPF1 Axis to Inhibit Apoptosis of Nerve Cells in AD : The Role of Dexmedetomidine in AD [0.03%]
地佐辛通过抑制长链非编码RNA SNHG14/UPF1轴促进HSPB8表达以抑制阿尔茨海默病中神经元细胞凋亡的机制研究：地佐辛在AD中的作用的校正文章
QingYun Tan,LiLi Liu,Shuo Wang et al.
QingYun Tan et al.
Published Erratum
Neurotoxicity research. 2025 Jan 25;43(1):6. DOI:10.1007/s12640-025-00728-4 2025
Exploring the Different Impacts of Ketamine on Neurotrophic Factors and Inflammatory Parameters in a Cecal Ligation and Puncture-Induced Sepsis Model [0.03%]
探讨氯胺酮对腹腔镜诱导的脓毒症模型中神经因子和炎症参数不同影响的研究
Jorge M Aguiar-Geraldo,Lara Canever,Debora P Marino et al.
Jorge M Aguiar-Geraldo et al.
Given ketamine's conflicting impacts on the central nervous system, investigating its effects within an inflammatory context becomes crucial. This study aimed to assess the impact of varying ketamine doses on neurotrophin and inflammatory c...