Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Amyloid Precursor Protein Processing in Neuronal Cell Lines [0.03%]
褪黑素通过抑制铁死亡和淀粉样前体蛋白处理来缓解神经细胞系中艾拉stin诱导的细胞死亡
Suwakon Wongjaikam,Puntita Siengdee,Alliya Somnus et al.
Suwakon Wongjaikam et al.
Ferroptosis is an iron-dependent and membrane lipid peroxidation-mediated form of programmed or regulated cell death. A number of recent studies have demonstrated that ferroptosis contributes to Alzheimer's disease (AD)-mediated nerve cell ...
Streptozotocin and L-Buthionine-Sulfoximine Decrease Neuron Membrane Lipid Packing and Alter Insulin Signaling [0.03%]
链球菌素和L-半胱氨酸硫氧苷亚硝胺减少神经膜脂质堆积并改变胰岛素信号转导
Yandara A Martins,Camila A E F Cardinali,Andressa P Costa et al.
Yandara A Martins et al.
Membrane composition, permeability and fluidity are essential for proper cellular function. According to the membrane aging hypothesis, aging-related diseases, including neurodegenerative disorders, arise from the aging of cell membranes. M...
The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with H2O2 [0.03%]
凋亡相关蛋白A1通过CAMK2/BECN1信号通路调节氧化应激诱导的浦肯野细胞自噬的保护作用
Shan Hui,Yi Long,Lemei Zhu et al.
Shan Hui et al.
This study investigates the potential protective role of annexin A1 (ANXA1) in cell models of H2O2-induced Alzheimer's disease. PC12 cells exposed to varying concentrations of H2O2 exhibited a dose-dependent decrease in cell viability. H2O2...
Exploring Retinal Neurodegeneration in Alzheimer's Disease: A Molecular and Cellular Perspective [0.03%]
阿尔茨海默病视网膜神经退行性变的分子与细胞机制研究进展
Rishika Dhapola,Prajjwal Sharma,Sneha Kumari et al.
Rishika Dhapola et al.
Increasing evidence of ocular impairments in Alzheimer's disease (AD) has drawn the attention of researchers worldwide towards retinal neurodegeneration in AD. The AD-associated changes observed in the retina include visual discrepancies, p...
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes [0.03%]
TRIM13通过调节小胶质细胞中TRAF6泛素化在甲基苯丙胺和HIV-1蛋白诱导的炎症反应及神经毒性协同作用中的机制研究
Yi Tan,Lin Miao,Chan Wang et al.
Yi Tan et al.
Methamphetamine (METH) abuse and HIV infection are major public health concerns worldwide. While both METH and HIV- 1 Tat proteins can induce neurotoxicity and synergistic effects on the nervous system, the mechanisms by which they act syne...
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults [0.03%]
非痴呆成人中血管紧张素转换酶、神经炎症与阿尔茨海默病脑脊液生物标志物之间的关联关系
Lan-Yang Wang,Hao Hu,Ze-Hu Sheng et al.
Lan-Yang Wang et al.
Recent studies have identified the angiotensin-converting enzyme (ACE) gene as a potential candidate influencing Alzheimer's disease (AD) risk. It is crucial to investigate the impact of ACE on AD pathology and its underlying mechanisms. A ...
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders [0.03%]
探讨微管相关蛋白-2在HIV相关神经认知障碍发病机制中的潜在作用
Melanie K Becher,Valeria Avdoshina,Lee A Campbell et al.
Melanie K Becher et al.
HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HAND is characterized by synapto-dendritic damage, yet the cause of this pathology is still under investigation. Various...
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction [0.03%]
犬尿氨酸途径在癫痫中的作用：解析其在谷氨酸兴奋性毒性、γ-氨基丁酸调节失常、神经炎症和线粒体功能障碍中的角色
Manpreet Kaur,Pratyush Porel,Royal Patel et al.
Manpreet Kaur et al.
Epilepsy is a chronic noncommunicable neurological disorder characterized by recurrent seizures and ranks as the seventh most prevalent neurological disease globally. According to the Global Burden of Disease report, 3.40 billion people wer...
Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking [0.03%]
使用网络毒理学和分子对接进行十溴二苯醚诱导的人神经毒性机制分析
Fuat Karakuş,Burak Kuzu
Fuat Karakuş
Commercial decabromodiphenyl ether (c-decaBDE) is a widely used additive flame retardant in textiles and plastics. This formulation predominantly consists of the congener BDE-209, with trace amounts of other brominated diphenyl ether congen...
Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage [0.03%]
氧四环素及其非抗生素衍生物DOT保护中脑多巴胺神经元免受铁驱动的氧化损伤
Thaís Antonia Alves Fernandes,Aurore Tourville,Ismaila Ciss et al.
Thaís Antonia Alves Fernandes et al.
This study aimed to investigate the neuroprotective potential of the tetracycline (TC) antibiotic oxytetracycline (OT) and its non-antibiotic derivative 4-dedimethylamino 12a-deoxy-oxytetracycline (DOT), in experimental conditions that mimi...