The Role of Mitochondrial Quality Control in Manganese-induced Neurotoxicity [0.03%]
线粒体质量控制在线皮质毒性中的作用
Alexey A Tinkov,Hyunjin Kim,Anatoly V Skalny et al.
Alexey A Tinkov et al.
The objective of the present review is to discuss the involvement of altered mitochondrial quality control in Mn-induced neurotoxicity. Existing data demonstrate that mitochondrial autophagy (mitophagy) and brain mitochondrial unfolded prot...
Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis [0.03%]
神经毒物暴露致母鼠产前应激致海马齿状回区持续性神经发生障碍相关促进轴突生长及突触可塑性的差异甲基化基因识别
Ryota Ojiro,Yasunori Takahashi,Qian Tang et al.
Ryota Ojiro et al.
Taurine Protects Against Melamine-Induced Hippocampal Neurotoxicity in Rats by Attenuating Metabolic Responses, Autophagy and Inflammation [0.03%]
牛磺酸通过减轻代谢反应、自噬和炎症来保护大鼠免受 melamine诱导的海马神经毒性
Adedeji David Atere,Mlungisi Patrick Msibi,Mega Obukohwo Oyovwi et al.
Adedeji David Atere et al.
Melamine, an industrial chemical linked to neurotoxicity, prompted this study investigating taurine's neuroprotective effects in rat brains. The study examined the impact of taurine on brain metabolic enzymes, neurochemicals, autophagy-rela...
Neuroinflammatory Mechanisms and Therapeutic Targets in Oxaliplatin-Induced Peripheral Neuropathy: a Comprehensive Review [0.03%]
奥沙利铂诱导的外周神经病的神经炎症机制和治疗靶点：全面综述
Sima Dehghani,Hamidreza Khorsandi,Rosa Hosseinzadegan et al.
Sima Dehghani et al.
Oxaliplatin-induced peripheral neuropathy (OIPN) is a severe, dose-limiting complication that significantly reduces quality of life in cancer patients, with no effective preventive or therapeutic options currently available. There is increa...
Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis [0.03%]
重叠分析调查环境暴露在肌萎缩侧索硬化病理中的潜在作用
Nazli Sila Kara,Ozan Ozisik,Anaïs Baudot et al.
Nazli Sila Kara et al.
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease causing motor neuron loss. 90-95% of ALS cases are sporadic, and the interplay of genetic predispositions and environmental exposures is essential in ALS patholo...
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson's Disease [0.03%]
新型小分子化合物DDOX在帕金森病动物模型中展现神经保护及改善运动缺陷的作用
Lorena Borges,Glauce Crivelaro do Nascimento,Laurent Ferrié et al.
Lorena Borges et al.
Tetracycline-derived compounds with anti-inflammatory properties have demonstrated neuroprotective potential in preclinical models of Parkinson's disease. In this study, we investigated the efficacy of DDOX (4-dedimethylamino 12a-deoxydoxyc...
A Balanced Cannabinoids Mixture Protects Neural Stem/progenitor Cells from CoCl2 Induced Injury by Regulating Autophagy and Inflammation: An in Vitro Study [0.03%]
一种平衡的大麻二酚混合物通过调节自噬和炎症保护CoCl2诱导的神经干细胞/前体细胞损伤：一项体外研究
Maryam Azarfarin,Tahereh Ghadiri,Ali Gorji et al.
Maryam Azarfarin et al.
Although tetrahydrocannabinol (THC) and cannabidiol (CBD) have been individually studied for their neuroprotective roles, few studies have addressed the effects of their balanced 1:1 formulation Satinex (STX) under pathologic conditions lik...
Neuroprotective Roles of Metformin in a Streptozotocin-Induced Dementia Model in Rats [0.03%]
二甲双胍在链脲佐菌素致痴呆大鼠模型中的神经保护作用
Adriana Fernanda Kuckartz Vizuete,Ana Paula Moreira,Lisandra Eda Fusinato Zin et al.
Adriana Fernanda Kuckartz Vizuete et al.
Alzheimer's disease (AD) is the leading cause of dementia in humans, with high social and economic costs. AD is predominantly a sporadic disorder, and its risk increases with age and in individuals with type 2 diabetes mellitus (T2DM). Metf...
Novel in silico Evidence of Bisphenol A as a Neuroinflammatory Modulator through the cGAS-STING-NLRP3 Pathway [0.03%]
新型的计算证据表明双酚A通过cGAS-STING-NLRP3通路发挥神经炎症调制作用
Veena V Tom,Sheshagiri Dixit,Karthik Pujar et al.
Veena V Tom et al.
Bisphenol A (BPA), a widely prevalent environmental contaminant, has been linked to neuroinflammation; however, the molecular mechanisms underlying this effect remain unclear. In this study, we used molecular docking and molecular dynamics ...
Development of a Novel Aluminium Chloride-Induced Zebrafish Model of Alzheimer's Disease: Involvement of Oxidative Stress, Cholinergic Dysfunction, and Gut Pathophysiology [0.03%]
一种新型铝氯化物诱导的斑马鱼阿尔茨海默病模型的发展：涉及氧化应激，胆碱能功能障碍和肠道病理生理学的影响
Rutvi Vaja,Mariya Vohra,A V Ramachandran et al.
Rutvi Vaja et al.
Alzheimer's Disease (AD) is a progressive and fatal neurodegenerative disorder (NDD), and the leading cause of dementia globally, with females being more susceptible than males. Existing animal models for AD are primarily pharmacologically ...