Neuroprotective Effects of Kinetin Against Glutamate-Induced Oxidative Cytotoxicity in HT22 Cells: Involvement of Nrf2 and Heme Oxygenase-1 [0.03%]
植物激素表皮生长因子的神经保护作用及其对HT22细胞中Nrf2和血红素氧合酶-1的作用机制研究
Yunpeng Wei,Dan Liu,Yin Zheng et al.
Yunpeng Wei et al.
Oxidative stress is considered as one of key factors related to Alzheimer's disease (AD), while kinetin (KT) has been reported to exert anti-oxidative activities as well as neuroprotective effects both in vivo and in vitro. Thus, in this st...
Comparative Examination of Temporal Glyoxalase 1 Variations Following Perforant Pathway Transection, Excitotoxicity, and Controlled Cortical Impact Injury [0.03%]
穿通路切断、兴奋毒性及可控性脑损伤后时间性甘油醛酶1变化的比较研究
Philipp Pieroh,Daniel-Christoph Wagner,Beat Alessandri et al.
Philipp Pieroh et al.
Following acute neuronal lesions, metabolic imbalance occurs, the rate of glycolysis increases, and methylglyoxal (MGO) forms, finally leading to metabolic dysfunction and inflammation. The glyoxalase system is the main detoxification syste...
Comparative Study
Neurotoxicity research. 2018 Feb;33(2):412-421. DOI:10.1007/s12640-017-9808-8 2018
Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-L-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring-Potential Involvement of DNA Damage and Oxidative Stress [0.03%]
暴露于胎氰毒素β-Ν-甲基胺-L-丙氨酸（BMAA）可导致后代长期的行为变化-潜在的DNA损伤和氧化应激参与作用
Anthony Laugeray,Asma Oummadi,Clément Jourdain et al.
Anthony Laugeray et al.
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like sym...
Neuromelanin in Parkinson's Disease: from Fenton Reaction to Calcium Signaling [0.03%]
帕金森病中的神经黑素：从芬顿反应到钙信号转导
Rainer Knörle
Rainer Knörle
Neuromelanin is supposed to play a key role in the pathogenesis of Parkinson's disease. A common theory is the formation of reactive oxygen species through the Fenton reaction catalyzed by neuromelanin-bound iron ions and subsequent death o...
A Panel of Autoantibodies Against Neural Proteins as Peripheral Biomarker for Pesticide-Induced Neurotoxicity [0.03%]
一组针对神经蛋白的自身抗体组成份作为农药诱导神经毒性的外周生物标志物
Heba Allah Abd El Rahman,Mohamed Salama,Seham A Gad El-Hak et al.
Heba Allah Abd El Rahman et al.
In the present study, we screened the sera of subjects chronically exposed to mixtures of pesticides (composed mainly of organophosphorus compounds (OPs) and others) and developed neurological symptoms for the presence of autoantibodies aga...
Erratum to: Assessing Cyanobacterial Harmful Algal Blooms as Risk Factors for Amyotrophic Lateral Sclerosis [0.03%]
有关论文“Amyotrophic Lateral Sclerosis风险因素评价中的蓝藻赤潮评估”的勘误项
Nathan Torbick,Beth Ziniti,Elijah Stommel et al.
Nathan Torbick et al.
Published Erratum
Neurotoxicity research. 2018 Jan;33(1):227. DOI:10.1007/s12640-017-9807-9 2018
Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects [0.03%]
解偶联蛋白2抑制加剧了血糖波动介导的神经效应
Susana Cardoso,Raquel M Seiça,Paula I Moreira
Susana Cardoso
Though glucose fluctuations have been considered as an adverse factor for the development of several diabetes-related complications, their impact in the central nervous system is still not fully elucidated. This study was conducted to evalu...
RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model [0.03%]
糖基化终产物诱导的载脂蛋白E依赖性血脑屏障β淀粉样蛋白转运增加与NF-κB信号通路活化有关
Fang Chen,Arijit Ghosh,Mei Hu et al.
Fang Chen et al.
The receptor for advanced glycation end products (RAGE) at the blood-brain barrier (BBB) is critical for regulation of amyloid-β (Aβ) homeostasis in the diabetic brain. In this study, we used an in vitro BBB model consisting of mouse brai...
Detection of the Cyanotoxins L-BMAA Uptake and Accumulation in Primary Neurons and Astrocytes [0.03%]
原代神经元和星形胶质细胞中莱鲍迪苷酸性藻毒素的检测及蓄积作用
Vanessa X Tan,Claire Mazzocco,Bianca Varney et al.
Vanessa X Tan et al.
We show for the first time that a newly developed polyclonal antibody (pAb) can specifically target the cyanotoxin β-methylamino-L-alanine (BMAA) and can be used to enable direct visualization of BMAA entry and accumulation in primary brai...
The Role of HINT1 in Methamphetamine-Induced Conditioned Place Preference [0.03%]
HINT1在甲基苯丙胺致条件位置偏爱中的作用研究
Ju-Ping Li,Peng Liu,Gang Lei et al.
Ju-Ping Li et al.
Drug addiction is a chronically relapsing disorder in humans; yet, the underlying mechanism remained unclear. Recent studies suggested that the histidine triad nucleotide binding protein 1 (HINT1) may play significant roles in diverse neuro...