Molecular and genetic features of a blaNDM-1 and blaSHV-12 coharboring hypermucoviscous Klebsiella pneumoniae of serotype K2 and ST65 [0.03%]
产ndm-1和blaSHV-12基因的黏液型克雷伯菌分子特征及遗传特性研究（血清型K2，序列类型ST65）
Yuting Kang,Qiujie Li,Wanting Ma et al.
Yuting Kang et al.
Purpose: This study aimed to assess the resistance phenotype, virulence phenotype, and genetic characteristics of a blaNDM-1 and blaSHV-12 co-harboring ST65 K2 Klebsiella pneumoniae (KP114), which was isolated from Genera...
In vitro activity of rifampicin, rifapentine and rifabutin in combination with their 25-deacetyl-metabolites against various Mycobacterium tuberculosis lineages [0.03%]
利福霉素、利福定和利福布汀及其25-去乙酰基代谢物对各种结核分枝杆菌谱系体外联合活性研究
Charlotte Genestet,Chloé Bourg,Elisabeth Hodille et al.
Charlotte Genestet et al.
Objectives: Rifamycin agents (rifampicin (RIF), rifapentine (RFP), rifabutin (RFB)) are the cornerstone of tuberculosis (TB) therapy. Rifamycins are metabolized into 25-deacetyl-metabolites, which have been described has ...
Characterization, genomic analysis and preclinical evaluation of the lytic Staphylococcus bacteriophage PSK against methicillin-resistant Staphylococcus aureus wound isolate [0.03%]
针对耐甲氧西林金黄色葡萄球菌伤口分离株的裂解性葡萄球菌噬菌体PSK的特性、基因组分析及临床前评估研究
Abanoub A Zanaty,Tarek Dishisha,Mohamed Abd El-Gawad El-Sayed-Ahmed et al.
Abanoub A Zanaty et al.
Background: The dissemination of multi-drug-resistant bacteria, particularly Methicillin-resistant Staphylococcus aureus (MRSA), necessitates exploring new alternatives for their control. Bacteriophages are promising anti...
Major blood stream infection-causing bacterial pathogens, antimicrobial resistance patterns and trends: a multisite retrospective study in Asmara, Eritrea (2014-2022) [0.03%]
主要引起血液感染的细菌病原体、抗菌耐药性模式和趋势：埃里特里亚阿斯马拉多站点回顾性研究（2014-2022年）
Yosan Gebremeskel Andemichael,Eyorusalem Tsehaye Habtetsion,Hagos Hayelom Gulbet et al.
Yosan Gebremeskel Andemichael et al.
Background: An important knowledge gap exists on the epidemiology of blood stream infections (BSIs) in low-middle-income countries (LMICs). In this retrospective analysis, we evaluated the etiology, antimicrobial resistan...
Host DNA depletion assisted metagenomic sequencing of bronchoalveolar lavage fluids for diagnosis of pulmonary tuberculosis [0.03%]
支气管肺泡灌洗液宿主DNA耗尽辅助的宏基因组测序在肺结核诊断中的应用
Jinfeng Yuan,Liping Ma,Juan Du et al.
Jinfeng Yuan et al.
Metagenomic next-generation sequencing (mNGS) has greatly improved our understanding of pathogens in infectious diseases such as pulmonary tuberculosis (PTB). However, high human DNA background (> 95%) impedes the detection sensitivity of m...
Diagnostics, resistance and clinical relevance of non-tuberculous mycobacteria unidentified at the species level by line probe assays: a bi-national study [0.03%]
线探针测定无法鉴定到物种水平的非结核分枝杆菌的诊断、耐药性和临床意义：一项两国研究
Matúš Dohál,Nils Wetzstein,Michaela Hromádková et al.
Matúš Dohál et al.
Objectives: While the reported incidence of non-tuberculous mycobacterial (NTM) infections is increasing, the true prevalence remains uncertain due to limitations in diagnostics and surveillance. The emergence of rare and...
Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights [0.03%]
肺炎克雷伯菌和大肠杆菌中新型新德里金属β-内酰胺酶的分子流行病学及表型特征分析
Noor Ul Ain,Linzy Elton,Zahra Sadouki et al.
Noor Ul Ain et al.
Background: Carbapenemase-producing Enterobacterales pose a serious clinical threat, particularly in high-burden settings of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae (CREK), where rapid detection to...
Comparison of phenotypic and genetic traits of ESBL-producing UPEC strains causing recurrent or single episode UTI in postmenopausal women [0.03%]
产后妇女复发性或单一发作尿路感染产ESBL的大肠杆菌菌株的表型和基因型特征比较分析
Michelle Kalu,Peter Jorth,Annie Wong-Beringer
Michelle Kalu
Background: Recurrent urinary tract infections (rUTIs) occur in over 20% of patients, with postmenopausal women (over 50 years old) carrying the highest risk for recurrence compared to younger women. Virulence factors suc...
Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model [0.03%]
克拉维林、阿米卡星和头孢西丁联合对黏液鲍曼不动杆菌感染的疗效有限：空腔纤维感染模型研究
Etienne Vignaud,Sylvain Goutelle,Charlotte Genestet et al.
Etienne Vignaud et al.
Background: Mycobacterium abscessus (MABS) causes difficult-to-treat pulmonary and extra-pulmonary infections. A combination therapy comprising amikacin, cefoxitin, and a macrolide agent is recommended, but its antimicrob...
Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk [0.03%]
结直肠癌中肠道息肉及肿瘤微环境的重塑：来自黏膜菌群和代谢物互作的研究启示
Hadi Feizi,Hossein Samadi Kafil,Andrey Plotnikov et al.
Hadi Feizi et al.
Background: Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed to be involved in CRC development. In this reg...