FDA-approved kinase inhibitors in PROTAC design, development and synthesis [0.03%]
FDA批准的激酶抑制剂在PROTAC设计、开发与合成中的应用
Kacper Kossakowski,Alina Cherniienko,Lucjusz Zaprutko et al.
Kacper Kossakowski et al.
FDA-approved kinase inhibitors represent a rapidly growing class of targeted therapies with proven clinical success in oncology. However, their occupancy-driven mode of action is often associated with resistance, off-target effects, and inc...
Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer [0.03%]
一种新型的RSK2抑制剂用于治疗转移性胰腺癌的发现
Chi-Hsiu Chung,Kai-Cheng Hsu,Ming-Min Huang et al.
Chi-Hsiu Chung et al.
Pancreatic cancer is among the most lethal malignancies, with a five-year survival rate of only 6%. For patients with metastatic disease, current treatments extend median survival by merely four months. This study addresses the urgent need ...
Hidden targets in dermatology: In vitro and In silico inhibitory effects of common 23 dermatologic drugs on human carbonic anhydrase isoenzymes I and II [0.03%]
皮肤科的隐秘目标：常见皮肤病药物对人碳酸酐酶同工酶I和II的体外和分子对接抑制作用
İlkay Can,Kübra Çıkrıkcı,Nahit Gençer et al.
İlkay Can et al.
In this study, we have aimed to determine the in vitro and in silico effects of 23 frequently used dermatologic drugs on human carbonic anhydrase I (hCA I) and II (hCA II). The inhibitory effects of the drugs on hCA I and hCA II were determ...
Correction [0.03%]
改正通知书
Design and synthesis of polymer nanoparticles with pH-responsive pan-HDAC inhibitor (C5) derived from norbornene block copolymers to increase C5 solubility and improve its targeted delivery to prostate cancer sites [0.03%]
基于降冰片烯嵌段共聚物的广谱HDAC抑制剂（C5）的pH响应性聚合物纳米粒的设计、合成及其在前列腺癌部位靶向递送中的应用研究
Jacob Mathew,Anshul Mishra,Trong-Nghia Le et al.
Jacob Mathew et al.
This study investigated the incorporation of C5, a pan-HDAC inhibitor, into a norbornene-derived block copolymer with pH-sensitive hydrolysis (PNEG-b-P(Nor-PABA-C5)) to generate NPs for prostate cancer treatment. Amphiphilic PNEG-b-P(Nor-PA...
Site-selective arylations of nature-inspired flavonoids or steroidal phenols via C-H or O-H activation [0.03%]
基于自然产物黄酮类或甾体酚的C-H/O-H活化位点选择性芳构化反应
Rebeka Ignácz,Noémi Bózsity,Dénes Unger et al.
Rebeka Ignácz et al.
Phenols are important structural elements of natural products and pharmaceuticals. Due to their versatile chemical transformability, phenols are frequently used building blocks in medicinal chemistry. Their aromatic nature allows directed C...
Nucleoside diphosphate kinase strongly promotes GDP and ADP metabolism in the cell and affects endogenous proton leak in mitochondria - the kinase is hampered by oxidative phosphorylation inhibitors [0.03%]
核苷二磷酸激酶在细胞中强烈促进GDP和ADP的代谢并影响线粒体内的内源性质子泄漏-该激酶受氧化磷酸化抑制剂阻碍
Andrzej M Woyda-Ploszczyca
Andrzej M Woyda-Ploszczyca
Rapid GDP metabolism in mitochondria isolated from wild-type yeast is postulated. The hallmark of exogenous GDP is convergence with the effect of exogenous ADP, typically inducing oxidative phosphorylation (OXPHOS). The GDP-provoked changes...
Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation [0.03%]
基于结构的药效团建模、虚拟筛选、分子对接、分子动力学模拟及PLK1-PBD和PLK4-PB3双靶点抑制剂的生物学评价
Changhao Zhao,Hanying Wu,Huajing Liu et al.
Changhao Zhao et al.
Aberrant expression of PLK1 and PLK4 is closely associated with tumourigenesis, and their simultaneous inhibition can effectively suppress tumour proliferation. In this study, we successfully identified peptide inhibitors (Peptides 1-5) cap...
Ligand-based discovery of novel N-arylpyrrole derivatives as broad-spectrum antimicrobial agents with antibiofilm and anti-virulence activity [0.03%]
基于配体的广谱抗菌剂新型N-芳基吡咯衍生物的发现及其具有抗生物被膜和降低毒力活性的作用
Basma M Qandeel,Samar Mowafy,Mohamed F El-Badawy et al.
Basma M Qandeel et al.
The escalating threat of antimicrobial resistance calls for novel therapeutic agents. This study employed a ligand-based design approach to develop three series of N-arylpyrrole derivatives (Va-e, VIa-e, and VIIa-e), refined through molecul...
Discovery of conformation constrained tetracyclic compounds as potent chitinase Of Chi-h inhibitors with a novel binding mode [0.03%]
发现构象约束四环化合物作为强效壳聚糖酶Chi-H抑制剂的新结合模式
Pengtao Yuan,Xi Jiang,Xintong Ni et al.
Pengtao Yuan et al.
Chitinase h (Chi-h) has been identified as a promising pesticide target due to its exclusive distribution in lepidopteran insects and its essential role in the moulting processes. In this study, we leverage OfChi-h from destructive agricult...