Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways [0.03%]
针对绝经后乳腺癌代谢失调的营养和运动干预的协同作用机制研究
Zhou Su,YunPeng Zhao,Xiaoqian Cui et al.
Zhou Su et al.
Postmenopausal females diagnosed with breast cancer who are undergoing aromatase inhibitor (AI) therapy often exhibit metabolic disturbances, which may manifest as insulin resistance, dyslipidemia, increased adiposity, and an elevated risk ...
Tumor microenvironment-responsive ARRDC4: unveiling the tumor-suppressive pathway in colorectal cancer progression [0.03%]
肿瘤微环境响应型ARRDC4：揭示结直肠癌进展中的抑癌途径
Jingwen Liu,Weiming Xu,Tianhui Pan et al.
Jingwen Liu et al.
Background: One of the leading causes of poor prognosis in colorectal cancer (CRC) patients is the presence of colorectal cancer-initiating cells (CCICs). The tumor microenvironment (TME) plays a role in the acquisition o...
APOE+ macrophages induce tumor cell metastatic characteristics via TNFSF12/TNFRSF12A signaling, correlating with poor patient prognosis [0.03%]
载有APOE的巨噬细胞通过TNFSF12 / TNFRSF12A信号传导诱导肿瘤细胞转移特性，与患者预后不良相关
Chuanjun Song,Hongyu Sun,Wenyuan Gan et al.
Chuanjun Song et al.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with metastasis representing a major determinant of poor prognosis. Epithelial-mesenchymal transition (EMT) promotes metastatic progression by enhancing tumor...
USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma [0.03%]
USP48通过去泛素化和稳定DBF4促进透明细胞肾癌的肿瘤进展
Lingfeng Zhu,Liuyan Chen,Lvying Wu et al.
Lingfeng Zhu et al.
Background: The upregulation of DBF4 is correlated with a poor prognosis in patients with clear cell renal cell carcinoma (ccRCC), yet the mechanisms governing the expression and protein stability of DBF4 remain unknown. ...
TIM-3 in AML: a janus-faced orchestrator of immune exhaustion and leukemic self-renewal [0.03%]
TIM-3在AML中的作用：介导免疫衰竭和白血病干细胞自我更新的双重调控角色
Ahmed Hjazi
Ahmed Hjazi
Acute Myeloid Leukemia (AML) remains a therapeutic challenge due to relapse driven by therapy-resistant leukemic stem cells (LSCs) and a profoundly immunosuppressive microenvironment. The immune checkpoint T-cell immunoglobulin and mucin-do...
Targeting KITENIN signaling in cancer progression and therapeutic resistance: mechanistic insights and future directions [0.03%]
针对KITENIN信号在癌症进展和治疗抵抗中的作用：机制见解与未来方向
S M Abdus Salam,Eshrat Jahan,Jeong A Bae et al.
S M Abdus Salam et al.
KITENIN (KAI1 C-terminal interacting tetraspanin) has emerged as a critical oncogenic mediator involved in tumor initiation, progression, metastasis, and therapeutic resistance. Initially identified through its interaction with the metastas...
Exosomal lncRNA NORAD drives oxaliplatin resistance in AEG via the miR-433-3p/autophagy axis: a novel mechanism and potential biomarker [0.03%]
外泌体长链非编码 RNA NORAD 通过 miR-433-3p 自噬轴驱动 AEG 顺铂耐药：一种新机制和潜在生物标志物
Huabing Ma,Jing Wang,Jiaxin Liu et al.
Huabing Ma et al.
Background: Oxaliplatin resistance poses a substantial therapeutic challenge in adenocarcinoma of the esophagogastric junction (AEG). Although the lncRNA NORAD has been implicated in chemoresistance, its specific role, un...
HER2-targeted doxorubicin-loaded cell-derived extracellular vesicles induce apoptosis of breast cancer cells via ROS/TXNIP pathway activation [0.03%]
HER2靶向表柔比星负载细胞源外泌体通过激活ROS/TXNIP信号轴诱导乳腺癌细胞凋亡
Chan Mi Lee,Do Sang Lee,Ji Won Choi et al.
Chan Mi Lee et al.
Background: Systemic toxicity and limited tumor selectivity remain major obstacles in HER2-positive breast cancer therapy with conventional chemotherapeutics. Extracellular vesicles (EVs) provide a promising delivery plat...
Circular RNAs in osteosarcoma: mechanistic insights, autophagy regulation, and potential therapeutic strategies [0.03%]
圆环RNA在骨肉瘤中的研究进展：作用机制、自噬调节和潜在治疗策略
Yong Zhang,Shiqi Zhao,Zhe Li et al.
Yong Zhang et al.
Osteosarcoma (OS) represents a highly aggressive malignant neoplasm of the bone, predominantly affecting pediatric and adolescent populations. Despite significant advancements in surgical techniques and chemotherapeutic regimens, patient pr...
Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms [0.03%]
多组学整合分析识别出参与核糖体生物发生具激活作用的肝癌相关巨噬细胞亚群及其关键基因GNL2并揭示其促进肝细胞肝癌进展的作用机制
Yajie Qi,Kun Li,Pincheng Li et al.
Yajie Qi et al.
Background: Liver hepatocellular carcinoma (LIHC) is a common malignancy, yet the core genes driving its progression and potential therapeutic targets remain insufficiently explored. Ribosome biogenesis (RB) is a critical...