USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma [0.03%]
USP48通过去泛素化和稳定DBF4促进透明细胞肾癌的肿瘤进展
Lingfeng Zhu,Liuyan Chen,Lvying Wu et al.
Lingfeng Zhu et al.
Background: The upregulation of DBF4 is correlated with a poor prognosis in patients with clear cell renal cell carcinoma (ccRCC), yet the mechanisms governing the expression and protein stability of DBF4 remain unknown. ...
TIM-3 in AML: a janus-faced orchestrator of immune exhaustion and leukemic self-renewal [0.03%]
TIM-3在AML中的作用：介导免疫衰竭和白血病干细胞自我更新的双重调控角色
Ahmed Hjazi
Ahmed Hjazi
Acute Myeloid Leukemia (AML) remains a therapeutic challenge due to relapse driven by therapy-resistant leukemic stem cells (LSCs) and a profoundly immunosuppressive microenvironment. The immune checkpoint T-cell immunoglobulin and mucin-do...
Targeting KITENIN signaling in cancer progression and therapeutic resistance: mechanistic insights and future directions [0.03%]
针对KITENIN信号在癌症进展和治疗抵抗中的作用：机制见解与未来方向
S M Abdus Salam,Eshrat Jahan,Jeong A Bae et al.
S M Abdus Salam et al.
KITENIN (KAI1 C-terminal interacting tetraspanin) has emerged as a critical oncogenic mediator involved in tumor initiation, progression, metastasis, and therapeutic resistance. Initially identified through its interaction with the metastas...
Exosomal lncRNA NORAD drives oxaliplatin resistance in AEG via the miR-433-3p/autophagy axis: a novel mechanism and potential biomarker [0.03%]
外泌体长链非编码 RNA NORAD 通过 miR-433-3p 自噬轴驱动 AEG 顺铂耐药：一种新机制和潜在生物标志物
Huabing Ma,Jing Wang,Jiaxin Liu et al.
Huabing Ma et al.
Background: Oxaliplatin resistance poses a substantial therapeutic challenge in adenocarcinoma of the esophagogastric junction (AEG). Although the lncRNA NORAD has been implicated in chemoresistance, its specific role, un...
HER2-targeted doxorubicin-loaded cell-derived extracellular vesicles induce apoptosis of breast cancer cells via ROS/TXNIP pathway activation [0.03%]
HER2靶向表柔比星负载细胞源外泌体通过激活ROS/TXNIP信号轴诱导乳腺癌细胞凋亡
Chan Mi Lee,Do Sang Lee,Ji Won Choi et al.
Chan Mi Lee et al.
Background: Systemic toxicity and limited tumor selectivity remain major obstacles in HER2-positive breast cancer therapy with conventional chemotherapeutics. Extracellular vesicles (EVs) provide a promising delivery plat...
Circular RNAs in osteosarcoma: mechanistic insights, autophagy regulation, and potential therapeutic strategies [0.03%]
圆环RNA在骨肉瘤中的研究进展：作用机制、自噬调节和潜在治疗策略
Yong Zhang,Shiqi Zhao,Zhe Li et al.
Yong Zhang et al.
Osteosarcoma (OS) represents a highly aggressive malignant neoplasm of the bone, predominantly affecting pediatric and adolescent populations. Despite significant advancements in surgical techniques and chemotherapeutic regimens, patient pr...
Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms [0.03%]
多组学整合分析识别出参与核糖体生物发生具激活作用的肝癌相关巨噬细胞亚群及其关键基因GNL2并揭示其促进肝细胞肝癌进展的作用机制
Yajie Qi,Kun Li,Pincheng Li et al.
Yajie Qi et al.
Background: Liver hepatocellular carcinoma (LIHC) is a common malignancy, yet the core genes driving its progression and potential therapeutic targets remain insufficiently explored. Ribosome biogenesis (RB) is a critical...
PPP1R18-mediated activation of Wnt/β-catenin and EMT is dependent on ERK signaling in clear cell renal cell carcinoma [0.03%]
PPP1R18介导的ERK信号依赖性的Wnt/β-catenin和EMT激活在透明细胞肾细胞癌中的作用
Xing Ji,Yongyang Yun,Zhenpeng Zhu et al.
Xing Ji et al.
Background: Advanced clear cell renal cell carcinoma (ccRCC) carries a dismal prognosis, urging the discovery of novel therapeutic targets. Here, we investigate the uncharacterized protein PPP1R18 as a potential driver of...
Single-cell and bulk omics uncover fibroblast heterogeneity and HSPH1 as a key driver in Barrett's esophagus to esophageal adenocarcinoma progression [0.03%]
单细胞和批量组学揭示巴雷特食管到食管腺癌进展中的成纤维细胞异质性和HSPH1的关键作用
Lulong Tao,Yanting Guo,Fang Lu et al.
Lulong Tao et al.
Background: Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with poor prognosis, often evolving from Barrett's esophagus (BE). Understanding the molecular mechanisms driving this progression is critical ...
Exosomal circPOLK promotes metastasis of NSCLC cells via regulating mir-1204/SOX8 axis [0.03%]
环状RNA circPOLK通过调节mir-1204/SOX8轴促进非小细胞肺癌细胞转移的研究
Yang-Ling Li,Ye-Han Liu,Jing Cheng et al.
Yang-Ling Li et al.
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis of NSCLC patients is still poor particularly for patients with metastatic disease. Thus, extending the knowledge about the mechanism of metastas...