Retraction Note: MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene [0.03%]
撤回 notice:MiR-20a-5p通过靶向KIF26B基因抑制成骨肉瘤的多药耐药性
Youguang Pu,Qiyi Yi,Fangfang Zhao et al.
Youguang Pu et al.
The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential [0.03%]
口腔鳞状细胞癌中的口腔微生物群：揭示机制和临床潜力
Amany Hany Mohamed Kamel,Nourhan El-Tantawy,Sarah Ahmed et al.
Amany Hany Mohamed Kamel et al.
Originating in the mucosal lining of the mouth, oral squamous cell carcinoma is the most common malignancy of the head and neck regions. Its pathogenesis is multifactorial, involving environmental exposures, genetic susceptibility, and life...
CAR-T and TIL therapies in solid tumors: barriers, clinical lessons, and convergent solutions [0.03%]
实体瘤的CAR-T和TIL治疗：障碍、临床经验及趋同解决方案
Duc-Hiep Bach,Van T Hoang,Thi Viet Pham et al.
Duc-Hiep Bach et al.
The approval of lifileucel in 2024 marked an important milestone in oncology as the first cellular therapy authorized for a solid tumor. This milestone stands in sharp contrast to the success of CAR-T cells in hematologic malignancies, wher...
Exosomes in cancer drug resistance: dual roles in therapy failure and emerging precision therapeutics [0.03%]
外泌体与癌症耐药：治疗失败和新兴精准治疗的双重角色
Bantayehu Addis Tegegne,Habtamu Belew,Zigale Hibstu Teffera et al.
Bantayehu Addis Tegegne et al.
Exosomes play a key role in cancer, functioning both as drivers of drug resistance and as tools for therapy. Tumor-derived exosomes facilitate intercellular communication through selective transfer of bioactive cargo, including proteins (e....
FOXA2 suppresses ESCC proliferation and metastasis by inhibiting PSMB9 expression, thereby attenuating proteasome activity [0.03%]
FOXA2通过抑制PSMB9表达来抑制食管鳞癌的增殖和转移，从而降低蛋白酶体活性
Wenqiang Xia,Ning Li,Chunxia Gong et al.
Wenqiang Xia et al.
Background: Esophageal squamous cell carcinoma (ESCC) represents a highly lethal malignancy. The FOXA2 was involved in cellular proliferation, differentiation, tumorigenesis, and metastasis. The precise regulatory mechani...
MRPL13 sustains mitochondrial integrity and MAPK-associated aggressiveness in esophageal squamous cell carcinoma [0.03%]
MRPL13通过维持食管鳞癌的线粒体完整性并促进MAPK相关恶性表型发挥促肿瘤作用
Shujuan Luo,Tao Liu,Qiaojuan Wang et al.
Shujuan Luo et al.
Background: Mitochondrial ribosomal protein L13 (MRPL13) has been implicated in tumor progression, but its relevance to esophageal squamous cell carcinoma (ESCC) remains insufficiently defined. Because mitochondrial adapt...
A multi-omics prognostic model integrating disulfidptosis-related molecular features in colorectal cancer [0.03%]
结直肠癌中结合二硫化酶作用分子特征的多组学预后模型
Huabin Zhou,Songrui Xiang,Yongjun Wu et al.
Huabin Zhou et al.
Background: Disulfidptosis is a recently described cell-death-related process associated with intracellular disulfide stress and may be relevant to tumor progression and immune regulation. However, its prognostic signific...
IL-12p40 drives oral squamous cell carcinoma progression via MMPs and IL-12Rβ1/STAT3 signaling [0.03%]
IL-12p40通过MMP和IL-12Rβ1/STAT3信号促进口腔鳞状细胞癌进展
Dongxiao Tang,Shaoqin Tu,Yiting Shao et al.
Dongxiao Tang et al.
Background: Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy with frequent lymphatic metastasis and poor clinical outcomes. IL-12p40, a shared subunit of IL-12 and IL-23, can engage IL-12Rβ1,...
Integrative plasma-to-spatial proteomics reveals fibroblast-associated signatures in liver metastatic breast cancer [0.03%]
集成血浆到空间蛋白质组学揭示乳腺癌肝转移相关的成纤维细胞特征
Elif Öcal,Janik Riese,Ursula Schneider et al.
Elif Öcal et al.
Background: Liver metastases from breast cancer (BCLM) are associated with aggressive disease and poor survival outcomes. Liver-directed locoregional therapies (LRT) based on radiation are limited by resistance and relaps...
Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma [0.03%]
基于机器学习的预后模型和单细胞转录组整合，用于识别肺癌腺癌脑转移相关的恶性亚群和潜在治疗靶点
Jingdan Pang,Wentian Wu,Peiwen Zhu et al.
Jingdan Pang et al.
Background: Lung adenocarcinoma (LUAD) is a highly prevalent and lethal form of lung cancer. Brain metastasis (BrM) is a major cause of mortality in patients with LUAD. The tumor microenvironment (TME) of LUAD BrM remains...