Cold atmospheric plasma affects metabolic processes in malignant melanoma [0.03%]
冷等离子体影响恶性黑色素瘤的代谢过程
Erika Rein,Tom Zimmermann,Stefan Fischer et al.
Erika Rein et al.
Background: Partially ionized gas, also known as cold atmospheric plasma (CAP), is reported to have anti-tumor specific properties via reactive oxygen and nitrogen species (RONS) in different tumor entities. Many CAP effe...
NPTXR as a novel therapeutic target: efficacy of antibody-drug conjugates in preclinical tumor models [0.03%]
NPTXR作为新型治疗靶点的疗效：抗体药物偶联物在肿瘤模型中的疗效研究
Mykola Lyndin,Michel Janicot,Justus Müller et al.
Mykola Lyndin et al.
Background: The neuronal pentraxin receptor (NPTXR) is mainly expressed in the cytoplasm of a subset of neuronal cells in the cerebral cortex. While NPTXR may be involved in mediating uptake of synaptic material during sy...
Quantifying target antigen-dependent CAR T-cell performance against AML [0.03%]
量化针对急性髓系白血病的CAR-T细胞依赖靶抗原的表现性能
Saumil Shah,Jan Mueller,Emanuel Vogel et al.
Saumil Shah et al.
Chimeric Antigen Receptor (CAR) T-cell therapy has transformed cancer immunotherapy by genetically engineering T-cells to target tumor antigens. Acute myeloid leukemia (AML) presents unique challenges due to resistance mechanisms, especiall...
Retraction Note: MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene [0.03%]
撤回 notice:MiR-20a-5p通过靶向KIF26B基因抑制成骨肉瘤的多药耐药性
Youguang Pu,Qiyi Yi,Fangfang Zhao et al.
Youguang Pu et al.
The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential [0.03%]
口腔鳞状细胞癌中的口腔微生物群：揭示机制和临床潜力
Amany Hany Mohamed Kamel,Nourhan El-Tantawy,Sarah Ahmed et al.
Amany Hany Mohamed Kamel et al.
Originating in the mucosal lining of the mouth, oral squamous cell carcinoma is the most common malignancy of the head and neck regions. Its pathogenesis is multifactorial, involving environmental exposures, genetic susceptibility, and life...
CAR-T and TIL therapies in solid tumors: barriers, clinical lessons, and convergent solutions [0.03%]
实体瘤的CAR-T和TIL治疗：障碍、临床经验及趋同解决方案
Duc-Hiep Bach,Van T Hoang,Thi Viet Pham et al.
Duc-Hiep Bach et al.
The approval of lifileucel in 2024 marked an important milestone in oncology as the first cellular therapy authorized for a solid tumor. This milestone stands in sharp contrast to the success of CAR-T cells in hematologic malignancies, wher...
Exosomes in cancer drug resistance: dual roles in therapy failure and emerging precision therapeutics [0.03%]
外泌体与癌症耐药：治疗失败和新兴精准治疗的双重角色
Bantayehu Addis Tegegne,Habtamu Belew,Zigale Hibstu Teffera et al.
Bantayehu Addis Tegegne et al.
Exosomes play a key role in cancer, functioning both as drivers of drug resistance and as tools for therapy. Tumor-derived exosomes facilitate intercellular communication through selective transfer of bioactive cargo, including proteins (e....
FOXA2 suppresses ESCC proliferation and metastasis by inhibiting PSMB9 expression, thereby attenuating proteasome activity [0.03%]
FOXA2通过抑制PSMB9表达来抑制食管鳞癌的增殖和转移，从而降低蛋白酶体活性
Wenqiang Xia,Ning Li,Chunxia Gong et al.
Wenqiang Xia et al.
Background: Esophageal squamous cell carcinoma (ESCC) represents a highly lethal malignancy. The FOXA2 was involved in cellular proliferation, differentiation, tumorigenesis, and metastasis. The precise regulatory mechani...
MRPL13 sustains mitochondrial integrity and MAPK-associated aggressiveness in esophageal squamous cell carcinoma [0.03%]
MRPL13通过维持食管鳞癌的线粒体完整性并促进MAPK相关恶性表型发挥促肿瘤作用
Shujuan Luo,Tao Liu,Qiaojuan Wang et al.
Shujuan Luo et al.
Background: Mitochondrial ribosomal protein L13 (MRPL13) has been implicated in tumor progression, but its relevance to esophageal squamous cell carcinoma (ESCC) remains insufficiently defined. Because mitochondrial adapt...
A multi-omics prognostic model integrating disulfidptosis-related molecular features in colorectal cancer [0.03%]
结直肠癌中结合二硫化酶作用分子特征的多组学预后模型
Huabin Zhou,Songrui Xiang,Yongjun Wu et al.
Huabin Zhou et al.
Background: Disulfidptosis is a recently described cell-death-related process associated with intracellular disulfide stress and may be relevant to tumor progression and immune regulation. However, its prognostic signific...