Molecular convergence in gallbladder cancer: MEK-ERK signalling at the crossroads of oncogenic hubs and pathway cross-talks [0.03%]
胆囊癌的分子汇聚现象：MEK-ERK信号通路在致癌中心及途径串扰的交叉点上的作用
Deeptima Jaiswar,Manjusha Dixit
Deeptima Jaiswar
Gallbladder cancer (GBC) is a highly aggressive malignancy with late presentation, limited therapeutic options, and dismal survival rates. Despite recent advances in molecular profiling, our understanding of GBC remains fragmented, with mos...
MicroRNA-29b-5p regulates cell proliferation and cancer stemness via TGF-β/p300 pathway in human synovial sarcoma [0.03%]
微小核糖核酸-29b-5p通过TGF-β/p300通路调节人类滑膜肉瘤细胞增殖和癌干细胞属性
HuiLing Xu,ShuangShuang Dong,Zhen Zhang et al.
HuiLing Xu et al.
Synovial sarcoma (SS) is a rare and aggressive soft tissue malignancy characterized by t(X;18)(p11.2;q11.2) translocation, which results in the SYT-SSX fusion gene. SS exhibits cancer stem cell-like properties that contribute to its invasiv...
TRIM15 Mediates ubiquitination of Paxillin to facilitate the progression of ovarian cancer [0.03%]
TRIM15通过泛素化Paxillin促进卵巢癌进展
Jiaqi Xu,Tiantian Wu,Fei Wu et al.
Jiaqi Xu et al.
Background: Globally, among gynecological malignancies, ovarian cancer (OC) stands as an important factor contributing to mortality. E3 ubiquitin ligase activity is a common characteristic found in the tripartite motif (T...
Targeting the NKG2D axis in head and neck squamous cell carcinoma: from molecular insights to clinical applications [0.03%]
靶向头颈鳞癌中NKG2D轴：从分子机制到临床应用
Parsa Alijanizadeh,Mahshid Shahmoradi,Amirhossein Kamroo et al.
Parsa Alijanizadeh et al.
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that evades immune surveillance by impairing the NKG2D receptor on natural killer (NK) cells and cytotoxic T lymphocytes. NKG2D recognizes stress-induced ligands (e.g., M...
Azza M El-Derby,Nouran T Salem,Noha Hesham et al.
Azza M El-Derby et al.
Oncolytic viruses (OVs) have emerged as a promising cancer therapy due to their natural selectivity to replicate in and destroy cancer cells. However, despite encouraging preclinical and early clinical outcomes, the therapeutic efficacy of ...
NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes [0.03%]
NUDT1促进骨肉瘤进展并可作为预测临床结果的可靠指标
Zhe Zhang,Lu Wan,Kai Ai et al.
Zhe Zhang et al.
Osteosarcoma (OS) is a primary bone malignancy characterized by high metastatic potential and poor prognosis. Nudix hydrolase 1 (NUDT1) plays a key role in preventing oxidative DNA damage, yet its functional significance in OS remains to be...
Repurposing melatonin for its potential roles in gastrointestinal cancers: highlighting the molecular mechanisms [0.03%]
褪黑素在胃肠癌症中的潜在作用及其分子机制
Kiana Yousefipour,Seyed Soheil Razavi Rohani,Sayed Mohammad Mahdi Hosseini et al.
Kiana Yousefipour et al.
Gastrointestinal (GI) cancers are among the most common cancers of the decade, many of which have a poor prognosis. Due to the high prevalence of toxicity and adverse drug reactions (ADRs) of chemotherapeutic agents and low patient complian...
ALDH18A1 regulates glutamine metabolism and tumor microenvironment in the attenuation of clear cell renal cell carcinoma [0.03%]
醛脱氢酶18家族成员A1通过调节谷氨酰胺代谢和肿瘤微环境抑制透明细胞肾细胞癌进展
Yang Fu,Xuzhong Liu,Qing Sun et al.
Yang Fu et al.
Objectives: To assess the potential role of glutamine metabolism-related genes (GMRGs) in the progression, prognosis, and immune microenvironment of clear cell renal cell carcinoma (ccRCC). ...
Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways [0.03%]
针对绝经后乳腺癌代谢失调的营养和运动干预的协同作用机制研究
Zhou Su,YunPeng Zhao,Xiaoqian Cui et al.
Zhou Su et al.
Postmenopausal females diagnosed with breast cancer who are undergoing aromatase inhibitor (AI) therapy often exhibit metabolic disturbances, which may manifest as insulin resistance, dyslipidemia, increased adiposity, and an elevated risk ...
Tumor microenvironment-responsive ARRDC4: unveiling the tumor-suppressive pathway in colorectal cancer progression [0.03%]
肿瘤微环境响应型ARRDC4：揭示结直肠癌进展中的抑癌途径
Jingwen Liu,Weiming Xu,Tianhui Pan et al.
Jingwen Liu et al.
Background: One of the leading causes of poor prognosis in colorectal cancer (CRC) patients is the presence of colorectal cancer-initiating cells (CCICs). The tumor microenvironment (TME) plays a role in the acquisition o...