Multi-dimensional profiling of lactylation-related signatures for prognostic and therapeutic insights in bladder cancer [0.03%]
膀胱癌乳酰化相关特征的多维度谱型分析及其预后和诊疗价值
Hongjun Zhao,Kangjing Li,Hexin Xu et al.
Hongjun Zhao et al.
Background: Bladder cancer (BCa) is a prevalent malignancy with challenging prognosis and management. Lactylation, a novel post-translational modification, is dysregulated in various cancers. This study investigates lacty...
Clinical application of cytokine-induced killer cells in cancer immunotherapy [0.03%]
细胞因子诱导的杀伤细胞在肿瘤免疫治疗中的临床应用
Farzaneh Ghorbani,Hossein Abbaszadeh,Yahya Yahyavi et al.
Farzaneh Ghorbani et al.
Cytokine-induced killer (CIK) cells exhibit potent antitumor activity with reduced dependence on strict MHC compatibility, mediated by a combination of T-cell receptor (TCR)-dependent recognition and natural killer (NK)-like, MHC-unrestrict...
Modulation of splicing factors SF3B1 and SRSF1 by polypurine reverse Hoogsteen hairpins affects the splicing pattern of estrogen receptor α in breast cancer cells [0.03%]
多聚嘌呤反向Hoogsteen发夹通过调节乳腺癌细胞中的剪接因子SF3B1和SRSF1影响雌激素受体α的剪接模式
Ester López-Aguilar,Judith Cullell,Ana Delgado et al.
Ester López-Aguilar et al.
Multiple mRNA splice variants for the human estrogen receptor α (ERα) with one or more skipped exons have been identified, and some encode isoforms with modified functions compared with the wild-type 66 kDa protein. Our aim was to evaluat...
Celastrol induces apoptosis of myelodysplastic syndrome cells through a ROS-dependent pro-apoptotic endoplasmic-reticulum stress pathway [0.03%]
celastrol通过ROS依赖性促凋亡的内质网应激途径诱导骨髓增生异常综合征细胞发生凋亡
Fuxiang Zheng,Wenjun Shao,Li Liu et al.
Fuxiang Zheng et al.
Background: Myelodysplastic syndromes (MDS) represent clonal hematopoietic stem cell disorders with inherent propensity for leukemic transformation. Emerging evidence implicates dysregulated Endoplasmic-Reticulum stress (...
The anti-leukemic effects of vitamin K4 by modulating the JAK/STAT signaling pathway [0.03%]
维生素K4通过调节JAK/STAT信号传导途径产生抗白血病作用
Xiuyu Li,Pengcheng Zhu,Shaowen Hu et al.
Xiuyu Li et al.
Background: Vitamin K4 (VK4) is a hemostasis medicine used in clinical practice. It has also been reported to possess anti-cancer properties in types of solid tumors, however, its antitumor effects in leukemia cells are u...
DNA damage response signature-based prognostic genes for intrahepatic cholangiocarcinoma: a combined analysis of machine learning and biological experiments [0.03%]
基于DNA损伤反应特征的肝内胆管癌预后基因：机器学习与生物实验结合分析发现预测指标
Kai Lu,Hanqi Li,Yinying Wu et al.
Kai Lu et al.
Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive subtype of primary liver cancer with insidious onset, early metastasis, and poor prognosis. DNA damage response (DDR) dysfunction is linked to ICC t...
ADH4 deficiency activates the NRF2-CSF1 axis by increased lipid peroxidation in hepatocellular carcinoma [0.03%]
ADH4缺乏通过增加肝细胞癌中的脂质过氧化激活NRF2-CSF1轴
Ping Yan,Yunhai Luo,Dadi Peng et al.
Ping Yan et al.
Background: Hepatocellular carcinoma (HCC) is frequently associated with serious metabolic disorders, resulting in a bleak prognosis. Although ADH4 is implicated in the metabolism of fatty acids, its exact function in tum...
Machine learning for postoperative complication prediction and early recurrence risk assessment across cancer types: a systematic review and meta-analysis [0.03%]
机器学习在术后并发症预测和癌症类型早期复发风险评估中的应用：系统回顾和meta分析
Wen Chen,Xinliang Liu,Zhenheng Wu et al.
Wen Chen et al.
Background: Although machine learning is often used in medical diagnosis, its effectiveness in cancer diagnosis remains uncertain. Objective: ...
Kaempferol-based nanocarriers as a potential therapeutic strategy against drug-resistant lung cancer [0.03%]
基于山柰酚的纳米递送系统作为治疗耐药性肺癌的潜在策略
Pouya Goleij,Mohammad Amin Khazeei Tabari,Danaé S Larsen et al.
Pouya Goleij et al.
Lung cancer is the predominant cause of cancer-related deaths, with chemoresistance posing a significant challenge for effective treatment. Drug resistance in lung cancer cells involves various cellular and molecular mechanisms, including t...
Molecular convergence in gallbladder cancer: MEK-ERK signalling at the crossroads of oncogenic hubs and pathway cross-talks [0.03%]
胆囊癌的分子汇聚现象：MEK-ERK信号通路在致癌中心及途径串扰的交叉点上的作用
Deeptima Jaiswar,Manjusha Dixit
Deeptima Jaiswar
Gallbladder cancer (GBC) is a highly aggressive malignancy with late presentation, limited therapeutic options, and dismal survival rates. Despite recent advances in molecular profiling, our understanding of GBC remains fragmented, with mos...