APLP2 as a molecular link between immune regulation and bone metabolism in hepatocellular carcinoma: evidence from scRNA-seq and functional validation [0.03%]
ALPLP2作为免疫调节和骨代谢之间分子联系的肝癌证据：来自单细胞 RNA 测序和功能验证的证据
Zhen Liang,Jinchang Zheng,Zhanpeng Su et al.
Zhen Liang et al.
Background and aims: Hepatocellular carcinoma (HCC) remains a significant health concern worldwide, characterized by elevated mortality rates that are often associated with diagnoses occurring in advanced stages and the r...
From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B [0.03%]
从生物信息学到临床：缺氧条件下PPBP通过CXCR2/PI3K/Akt信号促进胶质母细胞瘤进展并可被灯盏花素B靶向
Xianwen Cao,Yuansheng Fan,Jiaying Wang et al.
Xianwen Cao et al.
Background: Glioblastoma multiforme (GBM) is an aggressive brain cancer closely linked to hypoxic conditions and altered lactate metabolism. This study aims to investigate the prognostic factors of GBM by developing model...
Heterogeneous evolution of pancreatic cancer microvasculature revealed by longitudinal intravital imaging [0.03%]
基于纵向在体成像揭示的胰腺癌微血管异质性进化
Stephani Edwina Lucia,Sujung Hong,Reza Abdi et al.
Stephani Edwina Lucia et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate below 10%. Despite strong pro-angiogenic signaling often activated in PDAC, clinical trials with anti-angiogenic therapies have consistently f...
Transferrin receptor 1: an emerging therapeutic target in cancer beyond iron metabolism [0.03%]
transferrin受体1：一个超越铁代谢的抗癌治疗靶点
Xuefei Fu,Yuan Feng,Zhendong Wu et al.
Xuefei Fu et al.
Iron is an indispensable trace element for maintaining normal physiological functions in the body, participating in key biological processes such as energy metabolism, DNA synthesis, and damage repair. Under normal physiological conditions,...
Pinocembrin, an anticancer dihydroxyflavanone: from chemistry to cellular interactions and synergistic prospects [0.03%]
牻牛儿酮茋：从化学到细胞相互作用及增效前景的研究——一种抗肿瘤二氢黄烷醇翁牛儿醇酮.spliceโรงพยาบาล出院诊断模板中的splice似乎是拼写错误，正确的应该是"从化学到细胞相互作用及增效前景的研究——一种抗肿瘤二氢黄烷醇蒎牛儿酮。" 请确认需要保留原意还是进行调整。若按照正确拼写，应为：
牻牛儿酮：从化学到细胞相互作用及增效前景的研究——一种抗肿瘤二氢黄烷醇
Renu Chane,Shallu Saini,Rohit Bhatia et al.
Renu Chane et al.
Cancer remains a major global health challenge, with rising incidence and persistent therapy resistance highlighting the need for new multi-targeted therapeutic agents. Pinocembrin (5,7-dihydroxyflavanone), a naturally occurring flavanone f...
Fibronectin 1 mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells [0.03%]
纤连蛋白1介导结直肠癌细胞及癌症干细胞的压力诱导的侵袭性表型
Viet Cuong Nguyen,Kuang-Chao Cheng,Thuy-Tien Thi Phan et al.
Viet Cuong Nguyen et al.
Background: Multiple interacting factors within the tumor microenvironment, including mechanical pressure, extracellular matrix components, hypoxia, and vascular architecture, are known to promote cancer progression. Alth...
RANBP1 promotes oral cancer progression through activating YAP1 and NDUFB3 derived from the database of single-cell sequencing [0.03%]
基于单细胞测序数据库的RANBP1通过激活YAP1和线粒体呼吸链NDUFB3促进口腔癌进展
Wei-Chen Yen,Shu-Chen Liu,Shih-Sheng Jiang et al.
Wei-Chen Yen et al.
Oral cavity squamous cell carcinoma (OSCC) is the most common head and neck cancer, thriving in microenvironments composed of cancer cells, stromal tissue, and extracellular matrix. Extensive local invasion and cervical nodal metastasis can...
FGD3 as a prognostic and immunological biomarker: a pan-cancer analysis of its role in tumor progression and the immune landscape [0.03%]
FGD3作为预后和免疫生物标志物的作用：其在肿瘤进展和免疫景观中的角色的泛癌分析
Jing Zhu,Chun Yu,Xin Xu et al.
Jing Zhu et al.
Background: FGD3, a member of the FGD family, regulates GTPase activity and cellular morphology, thereby influencing tumor proliferation and migration. However, its role across diverse cancer types remains insufficiently ...
Retraction Note: LncRNA LIFR-AS1 promotes proliferation and invasion of gastric cancer cell via miR-29a-3p/COL1A2 axis [0.03%]
撤回 notice: LncRNA LIFR-AS1通过miR-29a-3p / COL1A2轴促进胃癌细胞增殖和侵袭
Haiyan Pan,Yuanlin Ding,Yugang Jiang et al.
Haiyan Pan et al.
A cilia-associated signature predicts resistance to anti-PD-1 immune checkpoint blockade therapy in lung adenocarcinoma [0.03%]
一种纤毛相关标志物可预测肺腺癌患者对抗PD-1免疫检查点阻断疗法的耐药性
Fei Zhou,Gaohua Feng,Xiaoshen Zhang et al.
Fei Zhou et al.
Background: Targeting immune checkpoints, specifically programmed death 1, has significantly improved clinical outcomes in non-small cell lung cancer. However, only a proportion of patients benefited from immune checkpoin...