Global landscape of protein-coding and long non-coding RNA alternative splicing and regulation in the human esophageal squamous cell carcinoma [0.03%]
人食管鳞状细胞癌中蛋白质编码和长链非编码RNA的可变剪接及调控的全局景观
Yunfei Wang,Jingkuan Yang,Shuling Li et al.
Yunfei Wang et al.
Background: Aberrant alternative splicing (AS) generates multiple isoforms from a single gene, leading to functional diversity and potentially contributing to tumorigenesis. The spliceosome pathway is significantly activa...
Correction: LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis [0.03%]
长链非编码RNA SPINT1-AS1通过miR-135b-5p/PGAM1轴增强瓦博格效应并促进骨肉瘤进展的纠正观点
Jinyou Wang,Ning Zhang,Yan Wang et al.
Jinyou Wang et al.
Published Erratum
Cancer cell international. 2026 Jun 19;26(1):234. DOI:10.1186/s12935-026-04375-3 2026
Next-generation CAR-NK cell therapy: engineering strategies, translational challenges, and future perspectives in cancer immunotherapy [0.03%]
下一代CAR-NK细胞治疗：癌症免疫疗法中的工程策略、转化挑战和未来前景
Minoo Bakhtiari,Hamid Nickho,Mahmoud Mahmoudi et al.
Minoo Bakhtiari et al.
Natural killer (NK) cells play a central role in innate immune surveillance and represent a promising platform for next-generation cancer immunotherapy. Recent advances in chimeric antigen receptor (CAR) engineering have accelerated the dev...
Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification [0.03%]
PLK4与PPM1D联合抑制促进17号染色体扩增的癌细胞死亡
Miroslav Stoyanov,Cecilia Aquino-Perez,Shreyasi Mazumder et al.
Miroslav Stoyanov et al.
Background: Polo-like kinase 4 (PLK4) is a key regulator of centriole duplication and contributes to mitotic spindle organization during cell division. PLK4 has been implicated as pharmacological target in a subset of bre...
BRD4 regulation of PIM1 identifies a novel therapeutic vulnerability in acute megakaryoblastic leukemia [0.03%]
BRD4调节的PIM1在急性巨核细胞白血病中的治疗脆弱性识别
Ailian Guo,Fang Fang,Peifang Xiao et al.
Ailian Guo et al.
Background: Acute megakaryoblastic leukemia (AMKL), a rare but aggressive subtype of acute myeloid leukemia (AML), currently has limited treatment options. Given the emerging role of super-enhancers (SEs) in governing onc...
Circadian rhythms and non-coding RNAs: mechanistic insights, clinical impact, and future opportunities for personalized medicine [0.03%]
昼夜节律与非编码RNA：机制见解、临床影响及精准医疗未来机遇展望
Mai A Abdelmawla,Heba R Ghaiad,Nora M Aborehab et al.
Mai A Abdelmawla et al.
Circadian rhythms are intrinsic 24-hour cycles that regulate diverse physiological processes, including sleep-wake cycles, metabolism, immune function, and hormone secretion. The molecular clockwork is made up of regulatory feedback loops a...
Correction: Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes [0.03%]
纠正：淋巴活化基因3蛋白在鼻咽癌中的表达与程序性死亡受体-1和程序性死亡配体-1、肿瘤浸润淋巴细胞有关
Fan Luo,Jiaxin Cao,Feiteng Lu et al.
Fan Luo et al.
Published Erratum
Cancer cell international. 2026 Jun 17;26(1):232. DOI:10.1186/s12935-026-04350-y 2026
Immunotherapy resistance in colorectal cancer: therapeutic strategies and biomarker-guided approaches [0.03%]
免疫疗法抵抗在结直肠癌中的作用：治疗策略和生物标志物指导的方法
Mahdi Jafarlou,Vahid Jafarlou,Samaneh Nouri et al.
Mahdi Jafarlou et al.
Overcoming immunotherapy resistance remains a major challenge in colorectal cancer (CRC), particularly because most tumors are microsatellite stable/proficient mismatch repair (MSS/pMMR) and respond poorly to immune checkpoint inhibitors (I...
Performance and pilot clinical validation of MALDITEC-CTC: a circulating tumor cell detection platform using whole-cell MALDI-TOF MS fingerprinting in osteosarcoma [0.03%]
基于基质辅助激光解吸电离飞行时间质谱技术检测骨肉瘤循环肿瘤细胞的性能及临床验证研究
Santhasiri Orrapin,Nutnicha Sirikaew,Wararat Chiangjong et al.
Santhasiri Orrapin et al.
Background: Osteosarcoma is a highly metastatic bone malignancy, with hematogenous spread as the leading cause of mortality. Circulating tumor cells (CTCs) offer a minimally invasive window to detect metastatic potential ...
An integrative framework combining Mendelian randomization, single-cell profiling, and experimental validation identifies FTMT as a mitochondrial-immune regulator in non-small cell lung cancer [0.03%]
结合孟德尔随机化、单细胞谱型和实验验证的综合框架鉴定FTMT为非小细胞肺癌中的线粒体-免疫调节因子
Shouyong Xiao,Siyun Wu,Xianfeng Shao et al.
Shouyong Xiao et al.
Background: Mitochondrial iron handling and immune surveillance are intertwined in tumor biology. Mitochondrial ferritin (FTMT) buffers redox-active iron in mitochondria, while MICB is an NKG2D ligand that can promote ant...