LLPS-based classification and a novel prognostic signature reveal NRF1 as a therapeutic target in pancreatic cancer [0.03%]
基于LLPS的分类和新型预后标志物揭示了NRF1可作为胰腺癌治疗靶点
Weishen Wang,Yi Zhao,Songyao Jiang et al.
Weishen Wang et al.
Background: Aberrant liquid-liquid phase separation (LLPS) can alter biomolecular condensate functions and may influence pancreatic tumorigenesis and progression, but the specific role of LLPS regulators in prognosis and ...
Macrophage-derived CTSZ promotes prostate cancer progression via αVβ3 integrin-mediated activation of the AKT/FOXO1/JUNB signaling axis [0.03%]
巨噬细胞衍生的CTSZ通过αVβ3整合素激活AKT/FOXO1/JUNB信号轴促进前列腺癌进展
Youxin Liu,Saipeng Chen,Jie Xu et al.
Youxin Liu et al.
Background: The tumor microenvironment (TME), especially tumor-associated macrophages (TAMs), plays a critical role in prostate cancer (PCa) progression. Cathepsin Z (CTSZ) is a lysosomal protease implicated in various ma...
Combining Mendelian randomization and multiomics data to determine the causal relationship between systemic inflammation and head and neck squamous cell carcinoma [0.03%]
结合孟德尔随机化和多组学数据确定系统性炎症与头颈部鳞状细胞癌之间因果关系的方法
Ke Yang,Guixin Zhu,Yanyan Li et al.
Ke Yang et al.
Background: Head and neck squamous cell carcinoma (HNSCC), the seventh most common cancer worldwide, is strongly associated with chronic inflammation. While chronic inflammation is often localized, systemic inflammation r...
Integrative analysis of SLFN11-related DEGs reveals novel biomarkers for cisplatin sensitivity and immune modulation in colorectal cancer [0.03%]
SLFN11相关差异基因的综合分析揭示了结直肠癌顺铂敏感性和免疫调节的新型生物标志物
Wei Wang,Lijiang Zhou,Jing Wang et al.
Wei Wang et al.
Background: Cisplatin is a widely used chemotherapy drug, but resistance mechanisms, including the role of SLFN11, pose significant challenges in colorectal cancer (CRC) treatment, with only 15-20% of patients showing obj...
TMEM33 regulates the proliferation and migration of lung adenocarcinoma by promoting the PI3K/AKT/mTOR signaling pathway [0.03%]
TMEM33通过促进PI3K/AKT/mTOR信号通路调节肺腺癌的增殖和迁移
Muli Wudu,Haijun Lou,Yuyu Ma et al.
Muli Wudu et al.
Lung adenocarcinoma is a common type of lung cancer with high incidence and mortality rates. TMEM33, a tumor-associated protein, has not been fully elucidated in lung adenocarcinoma. To explore the expression of TMEM33 in lung adenocarcinom...
The novel oleanolic acid derivative ZQL-4c modulates trastuzumab resistance in HER2+ breast cancer by inhibiting SCD-mediated lipid metabolism disorders [0.03%]
新型齐墩果酸衍生物ZQL-4c通过抑制SCD介导的脂质代谢紊乱调节HER2阳性乳腺癌耐药性
Yiwen Ma,Shisheng Wang,Xiaorui Li et al.
Yiwen Ma et al.
Approximately 15% to 20% of patients with breast cancer are human epidermal growth factor 2 (HER2)-positive, and this type has a high recurrence rate. With the application of anti-HER2 drugs such as trastuzumab, the prognosis of patients wi...
In silico repurposing of clinically approved drugs as potential BRAF inhibitors: a pharmacophore-based virtual screening and experimental investigation [0.03%]
基于药效团的虚拟筛选及实验研究已批准药物作为潜在BRAF抑制剂的再利用
Hooriehsadat Amini,Negin Ebrahimi,Sayedali Mousavirahimi et al.
Hooriehsadat Amini et al.
The BRAFV600E mutation is a key oncogenic driver in multiple cancers. While FDA-approved BRAF inhibitors exist, their efficacy is often limited by drug resistance and adverse effects, necessitating the discovery of novel therapeutic agents....
Cell line-dependent effects of β‑estradiol and testosterone on aurora kinases, GATA3, and associated miRNAs in hepatocellular carcinoma models HepG2 and Huh‑7 [0.03%]
雌二醇和睾酮对肝癌细胞系HepG2和Huh-7中aurora激酶、GATA3及相关miRNA的影响取决于细胞系本身的特点
Taraneh Rezaei,Mobina Abidi,Yaser Mohammadi et al.
Taraneh Rezaei et al.
Background: Higher prevalence of hepatocellular carcinoma (HCC) in men is largely attributed to the sex hormones and behavioral risk factors. This study investigated the effects of male (testosterone) and female (estradio...
Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6 [0.03%]
磷脂酰肌醇-3-激酶类二型α异构体在肝癌中通过抑制LRP6磷酸化靶向Wnt/β-catenin信号通路发挥新型抗转移作用
Jing Chen,Li-Xin Ren,Yong Ma et al.
Jing Chen et al.
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. The class II α-isoform of phosphatidylinositol 3-kinase (PIK3C2A) was found to be a regulator in proliferation and migration of endothelial c...
Integrating MRI radiomics and transcriptomics to predict IDH mutation status and prognosis in glioma [0.03%]
结合磁共振成像影像组学和转录组学预测胶质瘤IDH突变状态及预后
Rong-de Zhong,Qian Li,Heng Wang et al.
Rong-de Zhong et al.
Objective: To investigate MRI-based radiomic features in glioma and key genes related to IDH mutations, and to analyze their correlation. Methods: ...