From heterogeneity to mechanism: a systems-level analysis pinpoints the S100A8/A9 axis in colorectal cancer [0.03%]
从异质性到机制：系统水平分析确定S100A8/A9轴在结直肠癌中的作用
Hamideh Raeisi,Mahsa Saeedi Niasar,Ehsan Nazemalhosseini Mojarad et al.
Hamideh Raeisi et al.
Background: The functional roles of the S100 protein family in colorectal cancer (CRC) are enigmatic, marked by widespread dysregulation but limited prognostic utility. This heterogeneity obscures their potential as thera...
Xiaokun Chen,Xiao Liu,Jie Gong et al.
Xiaokun Chen et al.
Cancer metastasis remains a major obstacle in oncology and significantly worsens patient outcomes. A key challenge lies in understanding when and how tumor cells overcome biological barriers to spread, and to what extent external or interna...
Single-cell-marker-based subtyping and multi-level analyses uncover the prognostic effects, dysregulations and therapeutic indicative potential of an eight-gene signature in lung adenocarcinoma [0.03%]
基于单细胞标志物的亚型分类和多层次分析揭示八基因标记在肺腺癌预后、失调及治疗指示中的潜在作用
Xiuzhi Zhang,Fengqi Chen,Wenke Sun et al.
Xiuzhi Zhang et al.
Background: Lung adenocarcinoma (LUAD), the predominant subtype of non-small cell lung cancer, exhibits substantial molecular heterogeneity, complicating the identification of reliable prognostic and therapeutic markers. ...
Evaluation of ACMG/AMP guidelines for classifying APC variants in Korean patients with suspected familial adenomatous polyposis [0.03%]
评估ACMG/AMP指南在疑似家族性腺瘤性息肉病韩国患者APC变异分类中的适用性
Seo-Jin Park,Namsoo Kim,Dongju Won et al.
Seo-Jin Park et al.
Background: APC is the most frequently mutated gene in familial adenomatous polyposis (FAP). Recent advancements in sequencing technologies and the introduction of the 2024 APC-specific ACMG/AMP variant classification gui...
CD90 mediates gastric cancer immune evasion though regulating IGF2BP2 to stabilize the m6A-CD47/SIRPα axis [0.03%]
CD90通过调节IGF2BP2稳定m6A-CD47/SIRPα轴介导胃癌免疫逃逸
Siyi Liu,Lin Liang,Zihua Zhou et al.
Siyi Liu et al.
As a cell surface glycoprotein, CD90 plays a significant role in the initiation and progression of malignancies such as gastric cancer (GC) by influencing tumor cell proliferation, migration, and angiogenesis. However, its specific role in ...
Correction: ZNF655 promotes tumor growth and chemoresistance by targeting MAFF-CCND1 axis in ovarian cancer [0.03%]
校正：ZNF655通过靶向MAFF-CCND1轴促进卵巢癌的生长和化疗耐药性
Ying Xiong,Jiaxin Yin,Yulin Huang et al.
Ying Xiong et al.
Published Erratum
Cancer cell international. 2026 Jun 29;26(1):243. DOI:10.1186/s12935-026-04383-3 2026
PSMD8 promotes breast cancer progression and attenuates paclitaxel sensitivity by stabilizing KIF10 [0.03%]
PSMD8通过稳定KIF10促进乳腺癌进展和降低紫杉醇敏感性
Chenyuan Li,Xinyue Nie,Shichong Liao et al.
Chenyuan Li et al.
Background: Breast cancer (BC) patients have been threatened by distant metastasis and variations in treatment response for a long time. The mechanism urgently remains to be explored. ...
LLPS-based classification and a novel prognostic signature reveal NRF1 as a therapeutic target in pancreatic cancer [0.03%]
基于LLPS的分类和新型预后标志物揭示了NRF1可作为胰腺癌治疗靶点
Weishen Wang,Yi Zhao,Songyao Jiang et al.
Weishen Wang et al.
Background: Aberrant liquid-liquid phase separation (LLPS) can alter biomolecular condensate functions and may influence pancreatic tumorigenesis and progression, but the specific role of LLPS regulators in prognosis and ...
Macrophage-derived CTSZ promotes prostate cancer progression via αVβ3 integrin-mediated activation of the AKT/FOXO1/JUNB signaling axis [0.03%]
巨噬细胞衍生的CTSZ通过αVβ3整合素激活AKT/FOXO1/JUNB信号轴促进前列腺癌进展
Youxin Liu,Saipeng Chen,Jie Xu et al.
Youxin Liu et al.
Background: The tumor microenvironment (TME), especially tumor-associated macrophages (TAMs), plays a critical role in prostate cancer (PCa) progression. Cathepsin Z (CTSZ) is a lysosomal protease implicated in various ma...
Combining Mendelian randomization and multiomics data to determine the causal relationship between systemic inflammation and head and neck squamous cell carcinoma [0.03%]
结合孟德尔随机化和多组学数据确定系统性炎症与头颈部鳞状细胞癌之间因果关系的方法
Ke Yang,Guixin Zhu,Yanyan Li et al.
Ke Yang et al.
Background: Head and neck squamous cell carcinoma (HNSCC), the seventh most common cancer worldwide, is strongly associated with chronic inflammation. While chronic inflammation is often localized, systemic inflammation r...