IL-12p40 drives oral squamous cell carcinoma progression via MMPs and IL-12Rβ1/STAT3 signaling [0.03%]
IL-12p40通过MMP和IL-12Rβ1/STAT3信号促进口腔鳞状细胞癌进展
Dongxiao Tang,Shaoqin Tu,Yiting Shao et al.
Dongxiao Tang et al.
Background: Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy with frequent lymphatic metastasis and poor clinical outcomes. IL-12p40, a shared subunit of IL-12 and IL-23, can engage IL-12Rβ1,...
Integrative plasma-to-spatial proteomics reveals fibroblast-associated signatures in liver metastatic breast cancer [0.03%]
集成血浆到空间蛋白质组学揭示乳腺癌肝转移相关的成纤维细胞特征
Elif Öcal,Janik Riese,Ursula Schneider et al.
Elif Öcal et al.
Background: Liver metastases from breast cancer (BCLM) are associated with aggressive disease and poor survival outcomes. Liver-directed locoregional therapies (LRT) based on radiation are limited by resistance and relaps...
Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma [0.03%]
基于机器学习的预后模型和单细胞转录组整合，用于识别肺癌腺癌脑转移相关的恶性亚群和潜在治疗靶点
Jingdan Pang,Wentian Wu,Peiwen Zhu et al.
Jingdan Pang et al.
Background: Lung adenocarcinoma (LUAD) is a highly prevalent and lethal form of lung cancer. Brain metastasis (BrM) is a major cause of mortality in patients with LUAD. The tumor microenvironment (TME) of LUAD BrM remains...
CD133 structural instability as a gateway to medulloblastoma vulnerability [0.03%]
CD133结构不稳定作为胶质母细胞瘤易感性的途径
Zaira Spinello,Martina Brunetti,Natalia Pediconi et al.
Zaira Spinello et al.
Background: Medulloblastoma (MB) is the most common malignant paediatric brain tumor. Among distinct MB subtypes, Group 3 represents one of the most aggressive subtypes, with high relapse rate, frequent metastasis, and mo...
Bioinformatics analysis of PFKFB family in pan-cancer and preliminary exploration of PFKFB4 in bladder cancer [0.03%]
PFKFB家族泛癌分析及PFKFB4在膀胱癌中作用的初步探索
Yan Xu,Jian Xu,Chunyang Han et al.
Yan Xu et al.
Background: The phosphofructokinase-fructose bisphosphatases (PFKFBs) family is critical in tumors and the immune system. Nevertheless, the involvement of the PFKFB family genes in the immune microenvironment and prognosi...
Imaging mass cytometry reveals novel cellular neighborhoods for predicting the prognosis of nonalcoholic fatty liver disease-associated hepatocellular carcinoma [0.03%]
成像质谱流式细胞术揭示了非酒精性脂肪肝病相关肝细胞癌预后预测的新细胞区域
Bowen Xu,Xianming Wang,Xin Geng et al.
Bowen Xu et al.
Objective: We aimed to examine the panoramic cellular composition and spatial structure of clinical samples from nonalcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC), assess the landscape of th...
Integrative profiling of senescence-associated cells and genes identifies UGT1A7 as a prognostic and therapeutic target in Lung squamous cell carcinoma [0.03%]
集落细胞和基因的综合分析鉴定出UGT1A7是肺鳞状细胞癌预后和治疗靶点
Shengqiang Mao,Tong Deng,Zhiqiang Liu et al.
Shengqiang Mao et al.
Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to senescence-related biological processes. Meanwhile, senescence reshapes the tumor microenv...
M196R-TNFR2 and membrane TNFα down-regulate soluble TNFα-induced pro-metastatic functions in triple-negative breast cancer cells [0.03%]
M196R-TNFR2和膜TNFα下调可溶性TNFα诱导的三阴性乳腺癌细胞促转移功能
Shelly Adam-Shlanger,Michal Porat,Tamir Baram et al.
Shelly Adam-Shlanger et al.
Tumor necrosis factor α (TNFα) was connected to disease progression in breast cancer, through the activation of TNFR1 and, to some extent also of TNFR2, in cancer cells and/or in immune cells. We found that in triple-negative breast cance...
ANGPTL4 contributes to osimertinib resistance through NDRG1-associated extracellular matrix remodeling in EGFR-mutant NSCLC organoid models [0.03%]
ANGPTL4通过NDRG1相关细胞外基质重塑在EGFR突变NSCLC类器官模型中导致奥希替尼耐药性
Dai-Yan Zhou,Pei Xie,Si-Yuan Wang et al.
Dai-Yan Zhou et al.
Background: As a first-line treatment for EGFR-mutated non-small cell lung cancer (NSCLC), acquired resistance to osimertinib has become a major clinical challenge. Traditional two-dimensional cell culture models have sig...
KIF23 in disease pathogenesis and therapeutics : from molecular mechanisms to clinical translation [0.03%]
疾病发病机制和治疗中的KIF23：从分子机理到临床转化
Yi Liu,Yu Luo,Pinghong Hu et al.
Yi Liu et al.
Kinesin family member 23 (KIF23), a key regulator of cell division, has attracted growing interest owing to its aberrant expression and functional dysregulation in numerous human diseases. However, its systematic mechanisms of action across...