Blood-based molecular and cellular biomarkers of early response to neoadjuvant PD-1 blockade in patients with non-small cell lung cancer [0.03%]
非小细胞肺癌患者新辅助PD-1阻断的早期反应的血液分子和细胞生物标志物
Xi Zhang,Rui Chen,Zirong Huo et al.
Xi Zhang et al.
Background: Despite the improved survival observed in PD-1/PD-L1 blockade therapy, a substantial proportion of cancer patients, including those with non-small cell lung cancer (NSCLC), still lack a response. ...
Zhihao Yang,HaoYuan Wu,ZhiWei Wang et al.
Zhihao Yang et al.
Small extracellular vesicles (sEVs) are cell-derived, nanometer-sized particles enclosed by a lipid bilayer. All kinds of biological molecules, including proteins, DNA fragments, RNA, lipids, and metabolites, can be selectively loaded into ...
LINC00665 promotes the progression and immune evasion of lung cancer by facilitating the translation of TCF7 protein through dependence on IRES [0.03%]
长链非编码RNA LINC00665通过IRES依赖促进TCF7翻译从而加速肺癌进展和免疫逃逸
Chaonan Han,Jinchen Su,Yue Pei et al.
Chaonan Han et al.
Objective: To investigate the influence of LINC00665 on the development and immune evasion of lung cancer. Methods: Tumor tissues and c...
Pitavastatin sensitizes the EGFR-TKI associated resistance in lung cancer by inhibiting YAP/AKT/BAD-BCL-2 pathway [0.03%]
pitavastatin通过抑制YAP/AKT/BAD-BCL-2通路逆转表皮生长因子受体酪氨酸激酶抑制剂耐药性肺癌
Jie Liu,Jialei Fu,Ping Fu et al.
Jie Liu et al.
Background: Despite effective strategies, resistance in EGFR mutated lung cancer remains a challenge. Metabolic reprogramming is one of the main mechanisms of tumor drug resistance. A class of drugs known as "statins" inh...
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells [0.03%]
NFIC通过介导m6A mRNA甲基化来调控转录和转录后调节以抑制非小细胞肺癌细胞的恶性表型
Kesong Shi,Yani Chen,Ruihua Liu et al.
Kesong Shi et al.
Background: Multiple genetic and epigenetic regulatory mechanisms are crucial in the development and tumorigenesis process. Transcriptional regulation often involves intricate relationships and networks with post-transcri...
Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway [0.03%]
ABI2通过下调PI3K/Akt信号通路抑制TNBC细胞增殖依赖性降解
Linlin Lv,Shujing Li,Jie Kang et al.
Linlin Lv et al.
Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC. In this study, we obtain a ke...
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis [0.03%]
WZ-3146作为KIF4A的小分子抑制剂通过诱导凋亡抑制胶质瘤进展
Tao Yan,Qing Jiang,Guangpu Ni et al.
Tao Yan et al.
Background: Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...
Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution [0.03%]
基于乳腺癌患者的类器官探究患者特异性肿瘤的演变过程
Serena Mazzucchelli,Lorena Signati,Letizia Messa et al.
Serena Mazzucchelli et al.
Background: A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to investigate the tumour evolution before and after neoa...
Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study [0.03%]
用于乙基脲诱导的肺肿瘤的吲哚并[1,2-d]噻唑并[3,2-a]嘧啶类似物的抗增殖作用及其在体内和体外通过白化Wistar大鼠的凋亡途径的作用：一种计算研究
Archana Bharti Sonkar,Abhishek Verma,Sneha Yadav et al.
Archana Bharti Sonkar et al.
Lung cancer (LC) ranks second most prevalent cancer in females after breast cancer and second in males after prostate cancer. Based on the GLOBOCAN 2020 report, India represented 5.9% of LC cases and 8.1% of deaths caused by the disease. Se...
Monitoring measurable residual disease in paediatric acute lymphoblastic leukaemia using immunoglobulin gene clonality based on next-generation sequencing [0.03%]
基于下一代测序的免疫球蛋白基因克隆性检测儿童急性淋巴细胞白血病微小残留病
Won Kee Ahn,Kyunghee Yu,Hongkyung Kim et al.
Won Kee Ahn et al.
Background: Assessment of measurable residual disease (MRD) is an essential prognostic tool for B-lymphoblastic leukaemia (B-ALL). In this study, we evaluated the utility of next-generation sequencing (NGS)-based MRD asse...