PPP1R18-mediated activation of Wnt/β-catenin and EMT is dependent on ERK signaling in clear cell renal cell carcinoma [0.03%]
PPP1R18介导的ERK信号依赖性的Wnt/β-catenin和EMT激活在透明细胞肾细胞癌中的作用
Xing Ji,Yongyang Yun,Zhenpeng Zhu et al.
Xing Ji et al.
Background: Advanced clear cell renal cell carcinoma (ccRCC) carries a dismal prognosis, urging the discovery of novel therapeutic targets. Here, we investigate the uncharacterized protein PPP1R18 as a potential driver of...
Single-cell and bulk omics uncover fibroblast heterogeneity and HSPH1 as a key driver in Barrett's esophagus to esophageal adenocarcinoma progression [0.03%]
单细胞和批量组学揭示巴雷特食管到食管腺癌进展中的成纤维细胞异质性和HSPH1的关键作用
Lulong Tao,Yanting Guo,Fang Lu et al.
Lulong Tao et al.
Background: Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with poor prognosis, often evolving from Barrett's esophagus (BE). Understanding the molecular mechanisms driving this progression is critical ...
Exosomal circPOLK promotes metastasis of NSCLC cells via regulating mir-1204/SOX8 axis [0.03%]
环状RNA circPOLK通过调节mir-1204/SOX8轴促进非小细胞肺癌细胞转移的研究
Yang-Ling Li,Ye-Han Liu,Jing Cheng et al.
Yang-Ling Li et al.
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis of NSCLC patients is still poor particularly for patients with metastatic disease. Thus, extending the knowledge about the mechanism of metastas...
FAK inhibitor suppresses ovarian cancer growth by inhibiting tumor angiogenesis [0.03%]
FAK抑制剂通过抑制肿瘤血管生成来抑制卵巢癌生长
Jingtian Shen,Zhiru Su,Yihan Shan et al.
Jingtian Shen et al.
Background: Ovarian cancer, the second deadliest gynecological malignancy, necessitates the identification of novel therapeutic targets. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has emerged as a promis...
Multi-omics analysis of the mechanism by ATP13A2 regulates the tumor microenvironment and prognosis in hepatocellular carcinoma [0.03%]
ATP13A2调控肿瘤微环境和肝癌细胞癌预后的多组学分析
Yijie Weng,Changan Chen,Yueqing Cai et al.
Yijie Weng et al.
Background and aims: Hepatocellular carcinoma (HCC) is a prevalent global cancer. Most patients with HCC are diagnosed at an advanced stage. Therefore, new biomarkers and treatments are urgently needed. ...
Integrated analyses reveal a potential role for PFKFB4 in M2 macrophage polarization and hepatocellular carcinoma progression [0.03%]
综合分析揭示PFKFB4可能在M2型巨噬细胞极化和肝癌进展中发挥作用
Siying Wang,Qinqiu Zhang,Tian Li et al.
Siying Wang et al.
Background: Hepatocellular carcinoma (HCC) is the third most lethal malignant tumor worldwide, PFKFB4 has emerged as a key metabolic enzyme with critical roles in cancer progression and immune regulation. However, its pre...
In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects [0.03%]
基于吡唑并嘧啶的mTOR抑制剂的反筛、合成及抗癌和去老化功效评估
David Rysanek,Zofia Chrienova,Dorota Stary et al.
David Rysanek et al.
Background: Cellular senescence is a stress-induced state characterized by irreversible cell cycle arrest. Senescent cells accumulate during aging and contribute to age-related diseases, including neurodegeneration, cance...
Probiotic-derived EPS-ZnO nanoparticles: therapeutic potential in colorectal cancer gene regulation [0.03%]
益生元衍生的EPS-ZnO纳米颗粒：在结直肠癌基因调控中的治疗潜力
Saeideh Afsharipoor,Razieh Nazari,Anoosh Eghdami et al.
Saeideh Afsharipoor et al.
Colorectal cancer (CRC), the third most common and second deadliest cancer worldwide, arises from the abnormal growth of epithelial cells in the colon or rectum. This study focused on the oncogenes BCL9, KRAS, and WNT10A, alongside the tumo...
Hsa-miR-149-5p targets Men1 to inhibit the progression of gastric cancer through the HSPA6/JNK pathway [0.03%]
miR-149-5p通过HSPA6 / JNK通路靶向Men1抑制胃癌发展
Jin-Xun Jiang,Shi-Jie Zhang,Kun Zhao et al.
Jin-Xun Jiang et al.
Background: The mechanisms underlying gastric cancer (GC) progression, including recurrence and metastasis, remain unclear. Studies have reported that microRNAs and Men1 are closely associated with multiple tumors, includ...
Personalized immunotherapy in HCC: synthesis, delivery, and clinical progress of mRNA-based vaccines [0.03%]
基于mRNA疫苗的肝癌个性化免疫治疗：合成、递送及临床进展
Shirin Tavakoli,Ali Hassanzadeh,Maryam Samareh Salavatipour et al.
Shirin Tavakoli et al.
Messenger RNA (mRNA)-based vaccines have quickly developed as a unique approach to cancer immunotherapy with specific antigen expression, flexible design, and safety. They are broadly categorized into self-amplifying mRNA (SAM) vaccines and...