Metabolic Reprogramming of Brain Microglia: Implications for Aging and Aging-Associated Neurodegenerative Diseases [0.03%]
脑小胶质细胞的代谢重构：对衰老及与衰老相关神经退行性疾病的意义
Seokjo Kang,Helen S Goodridge
Seokjo Kang
Microglia, the resident macrophages of the central nervous system (CNS), are key players in maintaining brain and spinal cord homeostasis and protecting the CNS from damage and disease. During aging, the brain undergoes profound changes-inc...
Metabolic Reprogramming of Brain Microglia: Implications for Aging and Aging-Associated Neurodegenerative Diseases [0.03%]
脑微胶质细胞的代谢重构：衰老及衰老相关神经退行性疾病的启示
Seokjo Kang,Helen S Goodridge
Seokjo Kang
Microglia, the resident macrophages of the central nervous system (CNS), are key players in maintaining brain and spinal cord homeostasis and protecting the CNS from damage and disease. During aging, the brain undergoes profound changes-inc...
Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice [0.03%]
靶向RANKL可预防异染性老化小鼠的骨丢失、改善肌肉功能和延长寿命
Sandra Freitas-Rodríguez,Alejandra Valle-Cao,Francisco Rodríguez et al.
Sandra Freitas-Rodríguez et al.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by the early development of pathological features associated with aging, ultimately leading to premature death. HGPS primarily affects tissues of mesenchym...
Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland [0.03%]
线粒体决定乳腺逐渐衰老和突发式衰老
Edmund Charles Jenkins,Mrittika Chattopadhyay,Thelma Mashaka et al.
Edmund Charles Jenkins et al.
The incidence of breast cancer shows its largest peak around the age of 65 but also a peak around 45 indicating a bimodal distribution. While some potential explanations, such as age-related enrichment in specific breast cancer sub-types an...
Effects of Physical Activity on Brain White Matter Integrity Are Region-, Dose-, and Age-Dependent: Findings From the Population-Based Rhineland Study [0.03%]
基于人群的莱茵兰研究发现：运动对脑白质完整性的影响因区域、剂量和年龄而异
Eva Saxler,Fabienne A U Fox,Alexandra Koch et al.
Eva Saxler et al.
White matter integrity is a sensitive marker of cerebrovascular health and aging. Physical activity may promote white matter health, but previous studies were limited by self-reported activity and small sample sizes. We examined the associa...
HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1-Mediated Mitochondrial Metabolism [0.03%]
HNRNPC琥珀酰化通过YME1L1介导的线粒体代谢影响阿尔茨海默病神经退行性病变
Xuewei Li,Fan Yang,Yuyan Jiang et al.
Xuewei Li et al.
Mitochondrial dysfunction and abnormal energy metabolism are important pathological features of Alzheimer's disease (AD). This study investigates how mitochondrial protease YME1L1 affects mitochondrial function and its upstream regulation i...
Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age-Elevated Blood Pressure [0.03%]
内皮AGGF1缺乏导致线粒体功能障碍并有助于年龄升高血压
Weixin Lv,Xiaojuan Zhong,Qiang Yuan et al.
Weixin Lv et al.
Endothelial cells are critical in the regulation of blood pressure. We previously demonstrated AGGF1 was crucial for maintaining endothelial cell function. This study aims to examine whether AGGF1 regulates blood pressure. Here, we found th...
Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging [0.03%]
激活乳酸受体GPR81可改善衰老细胞和早衰模型中的衰老标志并改善肌肉功能
Pihu Mehrotra,Sai Harsha Bhamidipati,Pedro Lei et al.
Pihu Mehrotra et al.
Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis, leading to lipotoxicity and loss of muscle function. Here, we report that loss of the lactate receptor GPR81 in cellular and progeroid models of muscle ...
Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway [0.03%]
薯蓣皂苷通过激活SIRT1/PGC-1α信号通路促进卫星细胞增殖和肌发生从而缓解与年龄相关的肌肉减少症
Xin Zeng,Han Ding,Ziye Li et al.
Xin Zeng et al.
Age-related sarcopenia is characterized by a progressive decline in skeletal muscle mass and function, with satellite cell dysfunction representing a central pathogenic mechanism. Diosgenin, a steroidal saponin derived from plants of the Di...