Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target [0.03%]
葡萄糖代谢下降和分子伴侣功能衰退是衰老成纤维细胞生存的必要特征及丙酮酸脱氢酶是潜在的 senolytic 作用靶点
Mingzhu Zhang,Ziqi Hu,Shengwen Piao et al.
Mingzhu Zhang et al.
Cellular senescence contributes to aging and age-related diseases. Deep identifications of the senescence-specific cellular features are crucial to the better understanding of the survival and maintenance of senescence and the development o...
The Immune Cell Atlas of "Longevity Molecular Tag": Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms [0.03%]
“长寿分子标签”免疫细胞图谱：主要免疫细胞亚群及其潜在的分子调控机制鉴定
Zhiling Zhang,Huabin Su,Shihui Fu et al.
Zhiling Zhang et al.
Immunosenescence represents a critical aspect of the aging process. Centenarians, serving as a nature model of "healthy aging," demonstrate a distinctive immune "compensatory adaptation" mechanism that contributes to the maintenance of immu...
Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae [0.03%]
宿主衰老诱导中性粒细胞出现类似衰老的表型并改变对肺炎链球菌的转录反应
Michael C Battaglia,Manmeet Bhalla,Brandon Marzullo et al.
Michael C Battaglia et al.
Aging drives increased susceptibility to respiratory infections by Streptococcus pneumoniae (pneumococci). Polymorphonuclear leukocytes (PMNs) are among the first responders in the lung following pneumococcal infection and are required for ...
Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study [0.03%]
PM对表观遗传学衰老的效应及其受健康膳食模式的修饰作用——广州生物库队列研究
Rui Qiang Li,Shou Xin Peng,Rui Hang Zhang et al.
Rui Qiang Li et al.
Air pollution accelerates biological aging via oxidative stress and inflammation, a process potentially mitigated by plant-based diets. However, the role of dietary or genetic modulators in this relationship remains understudied. Our study ...
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment [0.03%]
细胞衰老的表观遗传标记不能被选择性杀死衰老细胞的药物逆转
Jessica Kasamoto,John González,Yaroslav Markov et al.
Jessica Kasamoto et al.
Epigenetic clocks are commonly used aging biomarkers based on DNA methylation that predict long-term morbidity and mortality risk. Increased cellular senescence with age is also posited to contribute to age-related disease and mortality. Ho...
Lactose-Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster [0.03%]
乳糖衍生的碳水化合物诱导果蝇营养程式效应性别差异的影响
Peixin Sun,Shiying Shao,Robin W Creemers et al.
Peixin Sun et al.
Early-life nutrition can exert long-lasting effects on later-life health. Given that lactose is extensively consumed during early mammalian development, this raises the intriguing possibility that lactose or its constituent galactose may ex...
Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice [0.03%]
老龄小鼠卵细胞代谢变化的跨代传递
Hafsa Gulzar,Richard Musson,Simona Bisogno et al.
Hafsa Gulzar et al.
The increase in maternal age of pregnancies is a global phenomenon that may have wide-ranging implications for the future health of the next generations. We have previously shown that oocytes from females at advanced maternal age (AMA F0) a...
Select Small Non-Coding RNAs Are Determinants of Survival in Older Adults [0.03%]
选择性小非编码RNA是老年人生存率的决定因素
Virginia Byers Kraus,Sisi Ma,Syeda Iffat Naz et al.
Virginia Byers Kraus et al.
To investigate the relevance of small RNAs to human longevity, we pursued three goals: (a) to validate epigenetic (small RNA) factors underlying survival of older adults, (b) to develop and validate prediction models of survival for potenti...
Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans [0.03%]
代谢基因HKDC1的沉默与小鼠和人类的衰老及神经退行性病变相关
Zeenat Farooq,Vladimir Ilievski,James Boyett et al.
Zeenat Farooq et al.
Increased life expectancy brought about by improved healthcare and lifestyle has heightened the challenge of neurodegenerative disorders like Alzheimer's disease (AD) and other age-related disorders. Neurodegeneration is known to be accompa...