Deyan Wang,Yiling Li,Mengmeng Li et al.
Deyan Wang et al.
Background: Salicaceae species have diverse sex determination systems and frequent sex chromosome turnovers. However, compared with poplars, the diversity of sex determination in willows is poorly understood, and little i...
Genomics and epigenetics guided identification of tissue-specific genomic safe harbors [0.03%]
基于基因组和表观遗传学的组织特异性基因组安全港位点识别
Dewan Shrestha,Aishee Bag,Ruiqiong Wu et al.
Dewan Shrestha et al.
Background: Genomic safe harbors are regions of the genome that can maintain transgene expression without disrupting the function of host cells. Genomic safe harbors play an increasingly important role in improving the ef...
DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis [0.03%]
阿拉伯芥中DNA甲基化奠定调控基因组转录的表观基因组图景
Lun Zhao,Qiangwei Zhou,Li He et al.
Lun Zhao et al.
Background: It is challenging to determine the effect of DNA methylation on the epigenetic landscape and the function in higher organisms due to the lack of DNA methylation-free mutants. ...
Author Correction: Towards accurate and reliable resolution of structural variants for clinical diagnosis [0.03%]
作者更正：朝向准确可靠地解决临床诊断的结构变异问题
Zhichao Liu,Ruth Roberts,Timothy R Mercer et al.
Zhichao Liu et al.
Published Erratum
Genome biology. 2022 Sep 20;23(1):198. DOI:10.1186/s13059-022-02773-0 2022
Goutham Atla,Silvia Bonàs-Guarch,Mirabai Cuenca-Ardura et al.
Goutham Atla et al.
Background: Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. Fo...
Comprehensive and scalable quantification of splicing differences with MntJULiP [0.03%]
利用MntJULiP全面且可扩展地量化剪接差异
Guangyu Yang,Sarven Sabunciyan,Liliana Florea
Guangyu Yang
Tools for differential splicing detection have failed to provide a comprehensive and consistent view of splicing variation. We present MntJULiP, a novel method for comprehensive and accurate quantification of splicing differences between tw...
Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa [0.03%]
在撒哈拉以南非洲测试祖先特异性多基因风险评分预测前列腺癌的泛化能力
Michelle S Kim,Daphne Naidoo,Ujani Hazra et al.
Michelle S Kim et al.
Background: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in...
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation [0.03%]
CPEB4阻抑物复合体介导的mRNA降解对早期基因表达的调控
Fabian Poetz,Svetlana Lebedeva,Johanna Schott et al.
Fabian Poetz et al.
Background: Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3' untranslated region (UTR) of specific mRNAs and assemble a...
Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation [0.03%]
脊椎动物CPEB蛋白的比较分析定义了两个在转录后基因调控中功能协调但又各不相同的亚家族
Berta Duran-Arqué,Manuel Cañete,Chiara Lara Castellazzi et al.
Berta Duran-Arqué et al.
Background: Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation elements (CPEs) in their 3' UTRs, leading to cytoplasmic changes in their poly(A) tail lengths; this can promote translational repression or a...
Positional motif analysis reveals the extent of specificity of protein-RNA interactions observed by CLIP [0.03%]
位置图谱分析揭示CLIP观测到的蛋白质-RNA相互作用的程度及特异性
Klara Kuret,Aram Gustav Amalietti,D Marc Jones et al.
Klara Kuret et al.
Background: Crosslinking and immunoprecipitation (CLIP) is a method used to identify in vivo RNA-protein binding sites on a transcriptome-wide scale. With the increasing amounts of available data for RNA-binding proteins ...