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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6360
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Tingting Qin,Christopher Lee,Shiting Li et al. Tingting Qin et al.
Background: Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set of enhancers and/or cel...
Tony Zeng,Yang I Li Tony Zeng
Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-...
Chloe X Wang,Lin Zhang,Bo Wang Chloe X Wang
Integrative analysis of large-scale single-cell RNA sequencing (scRNA-seq) datasets can aggregate complementary biological information from different datasets. However, most existing methods fail to efficiently integrate multiple large-scal...
Oren Ben-Kiki,Akhiad Bercovich,Aviezer Lifshitz et al. Oren Ben-Kiki et al.
Scaling scRNA-seq to profile millions of cells is crucial for constructing high-resolution maps of transcriptional manifolds. Current analysis strategies, in particular dimensionality reduction and two-phase clustering, offer only limited s...
Ángel Ferrero-Serrano,Megan M Sylvia,Peter C Forstmeier et al. Ángel Ferrero-Serrano et al.
Background: Genome-wide association studies (GWAS) aim to correlate phenotypic changes with genotypic variation. Upon transcription, single nucleotide variants (SNVs) may alter mRNA structure, with potential impacts on tr...
Danying Shao,Gretta D Kellogg,Ali Nematbakhsh et al. Danying Shao et al.
Reproducibility is a significant challenge in (epi)genomic research due to the complexity of experiments composed of traditional biochemistry and informatics. Recent advances have exacerbated this as high-throughput sequencing data is gener...
Ammar Tareen,Mahdi Kooshkbaghi,Anna Posfai et al. Ammar Tareen et al.
Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and massively parallel reporter assays on gene regulatory sequences. Despite their increasing popularity, a ge...
Jovan Tanevski,Ricardo Omar Ramirez Flores,Attila Gabor et al. Jovan Tanevski et al.
The advancement of highly multiplexed spatial technologies requires scalable methods that can leverage spatial information. We present MISTy, a flexible, scalable, and explainable machine learning framework for extracting relationships from...
Yanyan Zeng,Jing Li,Chaochun Wei et al. Yanyan Zeng et al.
The analysis of microbiome data has several technical challenges. In particular, count matrices contain a large proportion of zeros, some of which are biological, whereas others are technical. Furthermore, the measurements suffer from unequ...