MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions [0.03%]
MORC蛋白通过介导活性染色质区域的染色质压缩来调节转录因子结合
Zhenhui Zhong,Yan Xue,C Jake Harris et al.
Zhenhui Zhong et al.
Background: The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylatio...
Sarah Gersing,Matteo Cagiada,Marinella Gebbia et al.
Sarah Gersing et al.
Background: Glucokinase (GCK) regulates insulin secretion to maintain appropriate blood glucose levels. Sequence variants can alter GCK activity to cause hyperinsulinemic hypoglycemia or hyperglycemia associated with GCK-...
Identifying yield-related genes in maize based on ear trait plasticity [0.03%]
基于果穗性状可塑性鉴定控制玉米产量相关基因
Minguo Liu,Shuaisong Zhang,Wei Li et al.
Minguo Liu et al.
Background: Phenotypic plasticity is defined as the phenotypic variation of a trait when an organism is exposed to different environments, and it is closely related to genotype. Exploring the genetic basis behind the phen...
A graph neural network-based interpretable framework reveals a novel DNA fragility-associated chromatin structural unit [0.03%]
一种基于图神经网络的可解释框架揭示了新型DNA脆弱性相关的染色质结构单元
Yu Sun,Xiang Xu,Lin Lin et al.
Yu Sun et al.
Background: DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, and they can cause cancer if improperly repaired. Recent chromosome conformation capture techniques, such as Hi-C, have enabled the i...
Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells [0.03%]
结合不同的CRISPR核酸酶可同时实现同源重组敲入和碱基编辑，并防止CAR-T细胞中多基因组编辑造成的易位
Viktor Glaser,Christian Flugel,Jonas Kath et al.
Viktor Glaser et al.
Background: Multiple genetic modifications may be required to develop potent off-the-shelf chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand br...
Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data [0.03%]
转换配对文件可提高长读RNA测序数据变异调用工具的性能
Vladimir B C de Souza,Ben T Jordan,Elizabeth Tseng et al.
Vladimir B C de Souza et al.
Long-read RNA sequencing (lrRNA-seq) produces detailed information about full-length transcripts, including novel and sample-specific isoforms. Furthermore, there is an opportunity to call variants directly from lrRNA-seq data. However, mos...
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA [0.03%]
长链非编码RNA HIDEN通过与IMP1相互作用并稳定FZD5 mRNA来调节人内胚层分化
Pei Lu,Jie Yang,Mao Li et al.
Pei Lu et al.
Background: Extensive studies have revealed the function and mechanism of lncRNAs in development and differentiation, but the majority have focused on those lncRNAs adjacent to protein-coding genes. In contrast, lncRNAs l...
Author Correction: mbDenoise: microbiome data denoising using zero-inflated probabilistic principal components analysis [0.03%]
作者更正：mbDenoise：使用零膨胀概率主成分分析进行微生物组数据去噪
Yanyan Zeng,Jing Li,Chaochun Wei et al.
Yanyan Zeng et al.
Published Erratum
Genome biology. 2023 Apr 21;24(1):84. DOI:10.1186/s13059-023-02940-x 2023
CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping [0.03%]
利用ssDNA图谱直接分析dCas9和Cas9全基因组特异性的CasKAS系统
Georgi K Marinov,Samuel H Kim,S Tansu Bagdatli et al.
Georgi K Marinov et al.
Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they are generall...
YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2 [0.03%]
小胶质细胞中YY1乳酰化通过转录激活介导FGF2上调促进血管生成
Xiaotang Wang,Wei Fan,Na Li et al.
Xiaotang Wang et al.
Background: Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactyla...