Nikol Chantzi,Ilias Georgakopoulos-Soares
Nikol Chantzi
Background: Short tandem repeats (STRs) are widespread, dynamic repetitive elements with a number of biological functions and relevance to human diseases, genome plasticity and adaptation. However, their prevalence across...
A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem [0.03%]
胶质瘤免疫生态系统中的单细胞RNA选择性可变剪接图谱
Xiao Song,Deanna Tiek,Minghui Lu et al.
Xiao Song et al.
Background: Single-cell analysis has refined our understanding of cellular heterogeneity in glioma, yet RNA alternative splicing, a critical layer of transcriptome regulation, remains underexplored at single-cell resoluti...
A systematic evaluation of highly variable gene selection methods for single-cell RNA-sequencing [0.03%]
单细胞RNA测序的高可变基因选择方法的系统评估
Ruzhang Zhao,Jiuyao Lu,Yuzi Li et al.
Ruzhang Zhao et al.
Selecting highly variable genes (HVGs) is a critical step in single-cell RNA sequencing data analysis. We benchmark 47 HVG selection methods across 19 datasets, 18 evaluation criteria, and 5,358 settings. Hybrid methods – mixtures of multi...
Correction: iNOME-seq: in vivo simultaneous genome-wide mapping of chromatin accessibility, nucleosome positioning, DNA-binding protein sites, and DNA methylation in Arabidopsis [0.03%]
纠正：iNOME-seq：在阿拉伯芥中同时进行染色体可及性、核小体定位、DNA结合蛋白位点和DNA甲基化的全基因组测绘（体内）
Nosheen Hussain,Ryan Merritt,Julia Engelhorn et al.
Nosheen Hussain et al.
Published Erratum
Genome biology. 2025 Dec 10;26(1):423. DOI:10.1186/s13059-025-03888-w 2025
Transcriptional dynamics and chromatin accessibility in the regulation of shade-responsive genes in Arabidopsis [0.03%]
拟南芥荫蔽响应基因的转录动力学和染色质可及性调节研究
Sandi Paulišić,Alessandra Boccaccini,René Dreos et al.
Sandi Paulišić et al.
Background: Open chromatin regions host DNA regulatory motifs that are accessible to transcription factors and the transcriptional machinery. In Arabidopsis, responses to light are heavily regulated at the transcriptional...
Ancient genomes give insight into 160,000 years of East Asian population dynamics and biological adaptation [0.03%]
古代基因组揭示东亚16万年的群体动态和生物适应性
Guanglin He,Yuntao Sun,Shuhan Duan et al.
Guanglin He et al.
Advances in ancient DNA research have transformed our understanding of human evolution, admixture-driven adaptation, and genetic underpinnings of traits. However, the evolutionary dynamics of Paleolithic and Neolithic East Asian remain frag...
RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood [0.03%]
基于脐带血DNA甲基组变异性的个人、累积和互动的基因-环境贡献分析研究
Erick I Navarro-Delgado,Darina Czamara,Karlie Edwards et al.
Erick I Navarro-Delgado et al.
Genetic variation and environmental exposures are amongst the main factors associated with inter-individual DNA methylation variability. However, the prevalence and genomic context of individual, additive, and interactive gene-environment e...
Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes [0.03%]
组蛋白H2B泛素化在转录应激基因启动子和编码区域中起不同作用
Rubén Barrios,Montserrat Vega,Rebeca Gracia-Domingo et al.
Rubén Barrios et al.
AP1 is a pioneer transcription factor that programmes cell fate through MADS-domain protein tetramerisation [0.03%]
AP1是一个转录因子，通过MADS结构域蛋白四聚化来编程细胞命运
Xiaocai Xu,Manuel Neumann,Frederic Carew et al.
Xiaocai Xu et al.
Identifying cell-type-specific spatially variable genes with ctSVG [0.03%]
利用ctSVG识别具有空间异质性的细胞类型特异性基因
Haotian Zhuang,Xinyi Shang,Wenpin Hou et al.
Haotian Zhuang et al.
Spatially variable genes (SVGs) reveal the molecular and functional heterogeneity of cells across different spatial regions of a tissue. Sample-wide SVGs identified by existing methods largely overlap with cell-type marker genes derived fro...