An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease [0.03%]
William Gao,Peng Hu,Brittney Wick et al.
William Gao et al.
Background: As the first organ to develop in utero, the human heart undergoes extensive molecular, structural and metabolic remodeling during development and must sustain its function throughout life. ...
Cis-regulatory architecture downstream of FLOWERING LOCUS T underlies quantitative control of flowering in Arabidopsis thaliana [0.03%]
Hao-Ran Zhou,Duong Thi Hai Doan,Thomas Hartwig et al.
Hao-Ran Zhou et al.
Background: The FLOWERING LOCUS T (FT) gene is a central integrator of floral induction in Arabidopsis thaliana, with its precise expression controlled by complex transcriptional networks. While upstream regulatory region...
HistoGWAS: an AI-enabled framework for automated genetic analysis of tissue phenotypes in histology cohorts [0.03%]
Shubham Chaudhary,Almut Voigts,Michael Bereket et al.
Shubham Chaudhary et al.
Understanding how genetic variation shapes tissue structure is crucial for disease biology, yet scalable, general-purpose frameworks for genetic analysis of histology traits are lacking. We present HistoGWAS, a framework for genome-wide ass...
The pan-genome provides insights into evolutionary dynamics and fatty acid metabolism in Aceraceae family [0.03%]
Qiuyue Ma,Shushun Li,Zhongping Xu et al.
Qiuyue Ma et al.
Background: The Aceraceae family has ecological, ornamental and economical importance in plants. However, the genetic variations, evolution, and domestication of Aceraceae species are not well understood. Pan-genomes prov...
RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation [0.03%]
Yan Wang,Chunxu Yang,Rongjie Lin et al.
Yan Wang et al.
RNA modifications play pivotal roles in regulating RNA metabolism. Notably, they do not function in isolation, but crosstalk with DNA/protein modifications and other RNA modifications to form multi-layered regulatory networks that cooperati...
A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium [0.03%]
Thomas Balan,Ambre Petitalot,Julien Richard Albert et al.
Thomas Balan et al.
Background: The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1...
MRBEE-TL: improving causal effect estimation in multi-ancestry multivariable Mendelian randomization with transfer learning [0.03%]
Yihe Yang,Xiaofeng Zhu
Yihe Yang
Multivariable Mendelian randomization has been largely applied to individuals of European ancestry, due to the larger sample sizes available in European GWAS. We introduce MRBEE-TL, one of the first multi-ancestry multivariable Mendelian ra...
Ayun Luo,Hang-Yu Tian,Song Li et al.
Ayun Luo et al.
Background: All species of gibbons are endangered, with the Yunnan lar gibbons (Hylobates lar yunnanensis) officially declared extinct in the wild in 2022. While human activities are frequently cited as major factor, the ...
Benchmarking single-cell tumor immune atlases and application for uncovering cell states related to immunotherapy response [0.03%]
Jing Yang,Yu Shyr,Qi Liu
Jing Yang
Background: The tumor immune microenvironment, containing a variety of immune cells with both tumor-promoting and anti-tumoral functions, plays a significant role in tumor immune surveillance and immunological evasion. Ch...
Jiameng Xu,Ying Zhang,Ke Qing et al.
Jiameng Xu et al.
Background: Polycomb Repressive Complex 2 (PRC2) establishes H3K27me3 to regulate gene expression, yet how its genomic targeting is achieved in large crop genomes remains unclear. Cereal endosperm development relies on ti...