Denzel Eggermont,Lissa Eggermont,Nagihan Aslantaş et al.
Denzel Eggermont et al.
Background: Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) is implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems limit mechanistic insight. Here, ...
Advances in single-cell and spatial omics for studying symbiotic nitrogen fixation: comparative cellular and evolutionary perspectives [0.03%]
单细胞和空间组学在研究共生固氮作用方面的进展：比较细胞和进化视角
Yan Shi,Huiru Liu,Weicai Yang et al.
Yan Shi et al.
Single-cell and spatial transcriptomics have revolutionized studies of symbiotic nitrogen fixation by resolving cellular heterogeneity, spatial gene-expression, and regulatory dynamics within root nodules. Recent investigations in model leg...
Comparative centromere genomics reveals evolutionary divergence in Solanaceae genomes [0.03%]
比较中心体基因组学揭示了Solanceae基因组的进化分歧
Penglong Wan,Ming Hu,Hongyu Jin et al.
Penglong Wan et al.
Background: Centromeres are chromosomal loci epigenetically specified by the histone variant CENH3, where kinetochores assemble to ensure accurate chromosome segregation during cell division. Their repetitive and rapidly ...
GPU-accelerated linkage disequilibrium scans reveal non-independent assortment of human non-homologous chromosomes [0.03%]
基于GPU加速的连锁不平衡扫描揭示了人类非同源染色体之间的非独立分离现象
Wenhua Lv,Yuping Zou,Zhenwei Shang et al.
Wenhua Lv et al.
Background: The independence of assortment between loci on non‑homologous chromosomes, as proposed by Mendel's laws, has not been rigorously validated at the whole‑genome scale due to the computational demands of estima...
Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies [0.03%]
参考基因组和从头组装的Hi-C支架基准测试
Aakash Sur,William Stafford Noble,Peter J Myler
Aakash Sur
Background: Studying a new species using high-throughput sequencing requires a high-quality reference genome. However, assembling chromosome length sequences remains challenging. Recent advances in chromatin conformation ...
Evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulations [0.03%]
利用高保真 pedigrees 模拟评估古DNA遗传关系估计方法性能
Maël Lefeuvre,Marie-Claude Marsolier,Céline Bon
Maël Lefeuvre
Background: Recent advancements in paleogenetics, coupled with the emergence of dedicated statistical methods have, in recent years, streamlined the detection of close genetic ties from ancient DNA samples, leading to a s...
Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk [0.03%]
内源性逆转录病毒元件LTR8B和MER65通过重新调控PSG9来控制合体滋养层的融合以及子痫前期的风险
Manvendra Singh,Yuliang Qu,Amit Pande et al.
Manvendra Singh et al.
Background: Understanding the causes of the exceptional rate of evolution of the mammalian placenta is likely to aid the understanding of placental development and the etiology of the human-specific pregnancy disorder pre...
Tribolium madens satellitome reveals a network of highly abundant satellite DNAs in megabase-sized regions hallmarked by macro-dyad symmetries [0.03%]
拟步甲Tribolium madens的卫星序列组揭示了大型对称结构中的高度丰富的卫星DNA网络
Damira Veseljak,Evelin Despot-Slade,Marin Volarić et al.
Damira Veseljak et al.
Background: Tandemly repeated satellite DNAs (satDNAs) are among the most copious sequences of eukaryotic genomes. They often reside in centromeric regions, but their diversity among different organisms obscures the prope...
Augmented CENH3 loading is accompanied by transcriptional and epigenetic reprogramming at rice centromeres during meiosis [0.03%]
在水稻减数分裂过程中，伴随CENH3加载增强子，中心粒区域转录和表观遗传重编程
Lei Cao,Yangzi Zhao,Hanli You et al.
Lei Cao et al.
Background: Centromere identity in eukaryotes is defined epigenetically by CENH3 (CENPA), a specialized histone H3 variant essential for kinetochore establishment and faithful chromosome segregation. However, the regulato...
Systematic investigation of interindividual variation of DNA methylation in human whole blood [0.03%]
人类全血DNA甲基化个体差异的系统研究
Olivia A Grant,Meena Kumari,Leonard Schalkwyk et al.
Olivia A Grant et al.
Background: Interindividual genetic variability is well characterised, but we still lack a complete catalogue of loci displaying variable and stable epigenetic patterns. ...