Cosmopolitanism in the depths of Barbaricum evidenced by archaeogenomic data from the Late Iron Age Goth community of the Masłomęcz group [0.03%]
马尔索梅奇集团晚铁器时代哥特社区的考古基因组数据揭示了野蛮之地深处的文化世界主义现象
Michał Golubiński,Mateusz Baca,Danijela Popović et al.
Michał Golubiński et al.
Background: High mobility and extensive trade and military interactions are well recognized throughout the Late Iron Age Europe. The extremely rich archaeological record for the Masłomęcz group - a Goth-associated assem...
Genetic associations of circulating plasma proteins with cardiometabolic diseases [0.03%]
循环血浆蛋白与心血管代谢性疾病的遗传关联研究
Ruixin Zhou,Jun Qiao,Xiuzhen Zhang et al.
Ruixin Zhou et al.
Background: Cardiovascular disease is the leading cause of death worldwide, and its risk is closely linked to metabolic abnormalities. Through summary-data-based mendelian randomization and colocalization analysis, we inv...
Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution [0.03%]
单细胞分辨率下解决染色体外DNA的克隆演化和选择问题
Josephine Deleuran Hendriksen,Alessio Locallo,Balthasar Clemens Schlotmann et al.
Josephine Deleuran Hendriksen et al.
Background: Genomic alterations are a hallmark of cancer, and extrachromosomal DNA (ecDNA) has emerged as a key source of oncogene selection, tumor growth, and drug resistance. The intratumor heterogeneity and clonal sele...
stGCL: a versatile cross-modality fusion method based on multi-modal graph contrastive learning for spatial transcriptomics [0.03%]
基于多模态图对比学习的空间转录组学跨模性融合方法stGCL
Na Yu,Daoliang Zhang,Wei Zhang et al.
Na Yu et al.
3D epigenome architecture orchestrates cis and trans regulation of flowering time in rice [0.03%]
三维表观基因组架构调控水稻开花时间的顺式和反式调节
Yue Li,Zhanyi Zhang,Leilei Qiu et al.
Yue Li et al.
Background: Trimethylation of histone H3 lysine 27 (H3K27me3) confers a repressive chromatin state and is dynamically deposited and removed to regulate gene expression throughout plant growth and development. Nevertheless...
Paige Steppe,Katherine O&#x;Connor,Jeff Hasty
Paige Steppe
Engineered bacteria are emerging as a transformative class of cancer therapeutics. Recent advances in synthetic biology have expanded the genetic circuit toolbox, enabling the programmable control of attenuation, payload release, and immuno...
SCITO-seq2: ultra-high-throughput single-cell transcriptome and epitope sequencing [0.03%]
SCITO-seq2：超大规模单细胞转录组和表位测序
Su-Hyeon Lee,Bo-Yeong Jin,Cho-Rong Lee et al.
Su-Hyeon Lee et al.
We introduce SCITO-seq2, an enhanced successor to SCITO-seq that integrates probe-based RNA detection with the established ultra-high-throughput protein profiling. SCITO-seq2 achieves robust quantification of transcripts and surface protein...
Benpeng Miao,Xinlong Luo,Amina Ademovic et al.
Benpeng Miao et al.
Genome-resolved metagenomics uncovers diversity and functional landscapes of the gastrointestinal epithelium-associated microbiome in cattle [0.03%]
基因组解析宏基因组揭示了牛胃肠黏膜相关微生物群的多样性和功能景观
Limei Lin,Xinyi Zheng,Ye Tao et al.
Limei Lin et al.
Background: The ruminant gastrointestinal epithelium harbors a diverse and functionally critical remains poorly characterized microbial community due to persistent host-derived DNA contamination in metagenomic studies. ...
Accurate variant effect estimation in FACS-based deep mutational scanning data with Lilace [0.03%]
基于FACS的深度突变扫描数据中使用Lilace进行精确的变异效应估计
Jerome Freudenberg,Jingyou Rao,Matthew K Howard et al.
Jerome Freudenberg et al.
Deep mutational scanning (DMS) coupled with fluorescence-activated cell sorting (FACS) provides a high-throughput method to link genetic variants with quantitative molecular phenotypes. Analysis of these experiments is challenging due to me...