Defined bacterial consortium highlights the impact of intestinal bacteria on DNA methylation and tumorigenesis [0.03%]
一种定义良好的细菌群落突显了肠道菌群对DNA甲基化和肿瘤发生的影响
Claudia Mercado-Rodriguez,Siddhi Chitre,Pyoung Hwa Park et al.
Claudia Mercado-Rodriguez et al.
Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States. While the gut microbiota has been shown to influence CRC development, the specific contribution of bacteria...
Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana [0.03%]
拟南芥中转座子的体细胞移动具有爆炸性并受到独特的整合偏向塑造
Heena Ambreen,Basile Leduque,Leandro Quadrana et al.
Heena Ambreen et al.
Background: The movement of transposable elements (TEs) in somatic cells generates genetic and phenotypic diversity across the soma of individual organisms. This process is especially important in plants that display a se...
UK Biobank whole-genome sequencing reveals robust contributions of rare variants to complex-trait heritability [0.03%]
英国生物银行全基因组测序揭示罕见变异对复杂性状遗传率的显著贡献
Hyein Jung,Hae-Un Jung,Ji-One Kang et al.
Hyein Jung et al.
Background: The missing heritability of complex traits remains a key challenge in human genetics. Recent studies have highlighted the potential role of rare variants in addressing this gap. However, their contribution has...
A one-week automated genome-wide optical pooled screen using OttoSeq [0.03%]
基于OttoSeq的为期一周的自动化全基因组光学池筛检测方法
Bryce Kirby,Matteo Di Bernardo,Iain M Cheeseman et al.
Bryce Kirby et al.
Optical pooled screens (OPS) are bottlenecked by labor-intensive in situ sequencing and analysis protocols. Here, we present OttoSeq, an automated OPS platform combining the Otto2 fluid handling system with the Brieflow analysis pipeline. W...
Integrated lipidomic and transcriptomic profiling of the host response in human malaria [0.03%]
人类疟疾宿主反应的整合脂质组学和转录组学分析
Wael Abdrabou,Dariga Bolatbay,Issiaka Soulama et al.
Wael Abdrabou et al.
Background: Identifying the mechanisms of host-parasite interactions in vivo in malaria is essential for the development of antimalarial strategies tailored to clinically and physiologically relevant contexts. ...
Centromeric satellite expansion drives genome evolution in the snowy owl [0.03%]
雪鸮着丝粒卫星序列的扩增驱动基因组演化
Helle Tessand Baalsrud,Benedicte Garmann-Aarhus,Emily Louise Gilbert Enevoldsen et al.
Helle Tessand Baalsrud et al.
Background: Comparative genomic studies in birds have revealed that bird genomes are relatively repeat-poor and stable in terms of karyotype, size, and gene synteny/collinearity compared to other vertebrates. One notable ...
Wen-Ye Yao,Marta Gòdia,Lingzhao Fang et al.
Wen-Ye Yao et al.
Background: Allele-specific expression (ASE) is the imbalanced expression of two alleles of the same locus. It is quite pervasive among many species and is associated with health and economically relevant traits. ASE is o...
Genomic sequence evolution underlying human neocortical interareal diversification [0.03%]
人类新皮层区间多样化的基因组序列演化基础
Wei He,Weizhen Hou,Chengyong Jiang et al.
Wei He et al.
Background: Neocortical expansion and diversification in primates, especially humans, underpin advanced cognitive abilities, yet the molecular and cellular bases of neocortical area specification remain incompletely under...
Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits [0.03%]
酒精使用障碍及相关表型的功能性3' UTR变异体的调控机制
Andy B Chen,Xuhong Yu,Jennifer M Rupp et al.
Andy B Chen et al.
Background: Genetic variants in the 3' untranslated regions (3'-UTRs) of mRNAs can alter binding of RNA-binding proteins and microRNAs and thereby influence regulation by affecting RNA stability, localization, and transla...
A longitudinal single-nucleus transcriptomic atlas of bovine placentation reveals dynamic cellular hierarchies and regulatory programs [0.03%]
牛横向单核转录组胎盘图谱揭示了动态细胞等级和调节程序
Guanghui Tan,Xiaoru Yan,Xuesha Cao et al.
Guanghui Tan et al.
Background: Elucidating cellular hierarchies and regulatory mechanisms of placental development across gestation is critical for understanding pregnancy maintenance and improving reproductive outcomes in mammals, includin...