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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6360
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Zhana Duren,Fengge Chang,Fnu Naqing et al. Zhana Duren et al.
Technological development has enabled the profiling of gene expression and chromatin accessibility from the same cell. We develop scREG, a dimension reduction methodology, based on the concept of cis-regulatory potential, for single cell mu...
Michael Piechotta,Isabel S Naarmann-de Vries,Qi Wang et al. Michael Piechotta et al.
Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection a...
Ateeq M Khaliq,Cihat Erdogan,Zeyneb Kurt et al. Ateeq M Khaliq et al.
Background: Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironmen...
Dmitry E Andreev,Gary Loughran,Alla D Fedorova et al. Dmitry E Andreev et al.
Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality withi...
Jinzhuang Dou,Shaoheng Liang,Vakul Mohanty et al. Jinzhuang Dou et al.
Integration of single-cell multiomics profiles generated by different single-cell technologies from the same biological sample is still challenging. Previous approaches based on shared features have only provided approximate solutions. Here...
Jianzhi Yang,Mark J P Chaisson Jianzhi Yang
Variant benchmarking is often performed by comparing a test callset to a gold standard set of variants. In repetitive regions of the genome, it may be difficult to establish what is the truth for a call, for example, when different alignmen...
Yilin Xie,Yan Chen,Zijuan Li et al. Yilin Xie et al.
The precise spatiotemporal gene expression is orchestrated by enhancers that lack general sequence features and thus are difficult to be computationally identified. By nascent RNA sequencing combined with epigenome profiling, we detect acti...
Li Fang,Qian Liu,Alex Mas Monteys et al. Li Fang et al.
Despite recent improvements in basecalling accuracy, nanopore sequencing still has higher error rates on short-tandem repeats (STRs). Instead of using basecalled reads, we developed DeepRepeat which converts ionic current signals into red-g...
Rui Wang,Yunuo Mao,Wendong Wang et al. Rui Wang et al.
Background: Patient-derived organoid culture is a powerful system for studying the molecular mechanisms of cancers, especially colorectal cancer (CRC), one of the most prevalent cancers worldwide. There are two main types...