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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6360
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Ping Zhang,Harindra E Amarasinghe,Justin P Whalley et al. Ping Zhang et al.
Background: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activi...
Zhongli Xu,Elisa Heidrich-O&#x;Hare,Wei Chen et al. Zhongli Xu et al.
The recently developed method TEA-seq and similar DOGMA-seq single cell trimodal omics assays provide unprecedented opportunities for understanding cell biology, but independent evaluation is lacking. We explore the utility of DOGMA-seq com...
Advait Balaji,Bryce Kille,Anthony D Kappell et al. Advait Balaji et al.
The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge. To address this need we developed SeqScreen, whic...
Laura Fancello,Thomas Burger Laura Fancello
Background: Proteogenomics aims to identify variant or unknown proteins in bottom-up proteomics, by searching transcriptome- or genome-derived custom protein databases. However, empirical observations reveal that these la...
Nadav Brandes,Omer Weissbrod,Michal Linial Nadav Brandes
Genetic studies of human traits have revolutionized our understanding of the variation between individuals, and yet, the genetics of most traits is still poorly understood. In this review, we highlight the major open problems that need to b...
Daiwei Tang,Seyoung Park,Hongyu Zhao Daiwei Tang
A challenge in bulk gene differential expression analysis is to differentiate changes due to cell type-specific gene expression and cell type proportions. SCADIE is an iterative algorithm that simultaneously estimates cell type-specific gen...
Yanli Zhou,Chengjun Zhang,Li Zhang et al. Yanli Zhou et al.
Background: Events of gene fusion have been reported in several organisms. However, the general role of gene fusion as part of new gene origination remains unknown. ...
Mehran Karimzadeh,Michael M Hoffman Mehran Karimzadeh
Existing methods for computational prediction of transcription factor (TF) binding sites evaluate genomic regions with similarity to known TF sequence preferences. Most TF binding sites, however, do not resemble known TF sequence motifs, an...
Magda Markowska,Tomasz Cąkała,BłaŻej Miasojedow et al. Magda Markowska et al.
Copy number alterations constitute important phenomena in tumor evolution. Whole genome single-cell sequencing gives insight into copy number profiles of individual cells, but is highly noisy. Here, we propose CONET, a probabilistic model f...
Michael H Guo,Prashanth Sama,Brenna A LaBarre et al. Michael H Guo et al.
Background: Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral ...