Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition [0.03%]
稳定的母源蛋白决定了小鼠卵子到胚胎转变过程中独特的转录组、翻译组和蛋白质组的重新编程
Hongmei Zhang,Shuyan Ji,Ke Zhang et al.
Hongmei Zhang et al.
Background: The oocyte-to-embryo transition (OET) converts terminally differentiated gametes into a totipotent embryo and is critically controlled by maternal mRNAs and proteins, while the genome is silent until zygotic g...
SEESAW: detecting isoform-level allelic imbalance accounting for inferential uncertainty [0.03%]
翘翘板：在推断不确定性情况下检测亚型水平的等位基因不平衡
Euphy Y Wu,Noor P Singh,Kwangbom Choi et al.
Euphy Y Wu et al.
Detecting allelic imbalance at the isoform level requires accounting for inferential uncertainty, caused by multi-mapping of RNA-seq reads. Our proposed method, SEESAW, uses Salmon and Swish to offer analysis at various levels of resolution...
Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues [0.03%]
绘制无义介导的mRNA衰减调节在人类组织间的遗传变异图谱
Bo Sun,Liang Chen
Bo Sun
Background: Nonsense-mediated mRNA decay (NMD) was originally conceived as an mRNA surveillance mechanism to prevent the production of potentially deleterious truncated proteins. Research also shows NMD is an important po...
GreenHill: a de novo chromosome-level scaffolding and phasing tool using Hi-C [0.03%]
GreenHill：一种利用Hi-C从头进行染色体水平挂载和分型的工具
Shun Ouchi,Rei Kajitani,Takehiko Itoh
Shun Ouchi
Chromosome-level haplotype-resolved genome assembly is an important resource in molecular biology. However, current de novo haplotype assemblers require parental data or reference genomes and often fail to provide chromosome-level results. ...
Sayali Anil Alatkar,Daifeng Wang
Sayali Anil Alatkar
Multimodal measurements of single-cell sequencing technologies facilitate a comprehensive understanding of specific cellular and molecular mechanisms. However, simultaneous profiling of multiple modalities of single cells is challenging, an...
Tiago Maié,Marco Schmidt,Myriam Erz et al.
Tiago Maié et al.
DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. Here, we propose a computational framework named CimpleG for the detection of small CpG methylation signatures used for ...
Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences [0.03%]
通过与相邻内含子序列碱基配对，内含子小核仁RNA调控宿主基因的剪接事件
Danny Bergeron,Laurence Faucher-Giguère,Ann-Kathrin Emmerichs et al.
Danny Bergeron et al.
Background: Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced ...
HiCognition: a visual exploration and hypothesis testing tool for 3D genomics [0.03%]
HiCognition：一个用于三维基因组视觉探索和假设检验的工具
Christoph C H Langer,Michael Mitter,Roman R Stocsits et al.
Christoph C H Langer et al.
Genome browsers facilitate integrated analysis of multiple genomics datasets yet visualize only a few regions at a time and lack statistical functions for extracting meaningful information. We present HiCognition, a visual exploration and m...
Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6 [0.03%]
原钙黏着蛋白20通过靶向ATF6维持肠道屏障功能以防御克罗恩病
Shanshan Huang,Zhuo Xie,Jing Han et al.
Shanshan Huang et al.
Background: Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohn's disease. H...
Characterization of large-scale genomic differences in the first complete human genome [0.03%]
第一例人类完整基因组的第一个大规模基因组差异的特征描述
Xiangyu Yang,Xuankai Wang,Yawen Zou et al.
Xiangyu Yang et al.
Background: The first telomere-to-telomere (T2T) human genome assembly (T2T-CHM13) release is a milestone in human genomics. The T2T-CHM13 genome assembly extends our understanding of telomeres, centromeres, segmental dup...