Efficient glycosylase-mediated base editing with minimal off-target effects in mammalian embryos [0.03%]
高效的哺乳动物胚胎糖基化酶介导的碱基编辑器具备较少的脱靶效应
Yinghui Wei,Xi Cao,Shuhong Huang et al.
Yinghui Wei et al.
Developing glycosylase-based base editors (gBEs) to broaden the editing scope is highly desirable for biomedical research and agricultural applications. However, the off-target effects and applicability of gBEs need further investigation. W...
Publisher Correction: The genomic footprints of migration: how ancient DNA reveals our history of mobility [0.03%]
出版更正：迁移的基因组痕迹：古DNA如何揭示我们的流动性历史
Matthew P Williams,Christian D Huber
Matthew P Williams
Published Erratum
Genome biology. 2025 Oct 20;26(1):357. DOI:10.1186/s13059-025-03706-3 2025
Cell Decoder: decoding cell identity with multi-scale explainable deep learning [0.03%]
细胞解码器：利用多尺度可解释的深度学习进行细胞身份解码
Jun Zhu,Zeyang Zhang,Yujia Xiang et al.
Jun Zhu et al.
Background: Cells are the fundamental units of life, and understanding their diversity and functionality requires detailed characterization. The rise of single-cell omics data enables this, yet current deep learning appro...
Martin Hemberg,Federico Marini,Shila Ghazanfar et al.
Martin Hemberg et al.
The field of single-cell biology is growing rapidly, generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal,...
SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations [0.03%]
SPAmix：一种用于混合人群大规模遗传关联研究的可扩展、准确且通用的分析框架
Yuzhuo Ma,He Xu,Ying Li et al.
Yuzhuo Ma et al.
Background: Inclusion of individuals with diverse or admixed genetic ancestries is crucial to discover novel findings that may be missed by genomics analyses rooted solely in European population. ...
Reference genome bias in light of species-specific chromosomal reorganization and translocations [0.03%]
针对物种特异性染色体重组和易位的参考基因组偏差
Marius F Maurstad,Siv Nam Khang Hoff,José Cerca et al.
Marius F Maurstad et al.
Background: Whole-genome sequencing efforts, have during the past decade, unveiled the central role of genomic rearrangements-such as chromosomal inversions-in evolutionary processes, including local adaptation in a wide ...
sCCIgen: a high-fidelity spatially resolved transcriptomics data simulator for cell-cell interaction studies [0.03%]
sCCIgen：一种高保真的空间分辨转录组数据模拟器用于细胞间相互作用研究
Xiaoyu Song,Joselyn C Chavez-Fuentes,Weiping Ma et al.
Xiaoyu Song et al.
Spatially resolved transcriptomics (SRT) facilitates the study of cell-cell interactions within native tissue environments. To support method development and benchmarking, we introduce sCCIgen, a real-data-based simulator that generates hig...
Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development [0.03%]
空间和单细胞表达分析揭示了小麦穗发育早期复杂的表达区域
Xiaosa Xu,Huiqiong Lin,Junli Zhang et al.
Xiaosa Xu et al.
Background: Wheat is important for global food security. Understanding the molecular mechanisms driving spike and spikelet development can benefit the development of more productive varieties. ...
iPro-MP: a BERT-based model to predict multiple prokaryotic promoters [0.03%]
基于BERT的预测原核生物启动子的模型:iPro-MP
Wei Su,Yuhe Yang,Yafei Zhao et al.
Wei Su et al.
Background: Promoters, as essential cis-regulatory elements in prokaryotes, govern gene expression by mediating RNA polymerase binding through core motifs and long-range regulatory interactions, playing a pivotal role in ...
A novel gene expression stability metric to unveil homeostasis and regulation [0.03%]
一种新的基因表达稳定性度量方法用于揭示稳态和调节机制
Mengjie Chen
Mengjie Chen
We explore the concept of gene expression stability within a homeostatic cell through the gene homeostasis Z-index, a measure that highlights genes under active regulation in response to internal and external stimuli. The Z-index uncovers d...