Deciphering functional landscapes of rumen microbiota unveils the role of Prevotella bryantii in milk fat synthesis in goats [0.03%]
破译瘤胃微生物组的功能景观揭示Prevotella bryantii在山羊乳脂合成中的作用
Yu Lei,Yining Zheng,Yiting Yan et al.
Yu Lei et al.
Background: The rumen microbiome is critical for regulating milk synthesis in dairy livestock, yet the molecular mechanisms linking microbial functions to host lipid metabolism remain poorly understood. While host genetic...
Dissecting the genetic architecture of circadian rhythms in human tissues using a quantitative circadian deviation score [0.03%]
利用定量昼夜节律偏差评分分析人类组织中昼夜节律的遗传结构
Zheyu Li,Liang Chen
Zheyu Li
Background: Circadian rhythms influence various physiological and behavioral processes, including sleep, metabolism, and immune response. Although key regulatory factors of biological clocks have been identified and genom...
Land plant-specific H3K27 methyltransferases ATXR5 and ATXR6 control plant development and stress responses [0.03%]
陆生植物特有的组蛋白H3K27甲基转移酶ATXR5和ATXR6调控植物发育及胁迫响应
Xiaoyi Li,Jie Pan,Qian Liu et al.
Xiaoyi Li et al.
Background: Histone modifications are critical for transcriptional regulation. A notable genetic innovation in land plants is the emergence of histone lysine methyltransferases ATXR5/6, which specifically catalyze the rep...
Determinants of de novo mutations in extended pedigrees of 43 dog breeds [0.03%]
来自43个犬品种的大家系中新生突变的发生率和决定因素
Shao-Jie Zhang,Jilong Ma,Meritxell Riera et al.
Shao-Jie Zhang et al.
Background: Understanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recom...
Antagonistic effects of selection on alleles associated with seed size and seed dormancy in wheat [0.03%]
小麦籽粒大小和休眠位点受选择效应的影响
Feilong Guo,Changbin Yin,Tian Li et al.
Feilong Guo et al.
Background: Seed dormancy and size are two crucial traits influencing crop yield, and they have undergone strong selection during cereal domestication and improvement. However, the genetic basis underlying the antagonisti...
scKAN: interpretable single-cell analysis for cell-type-specific gene discovery and drug repurposing via Kolmogorov-Arnold networks [0.03%]
基于柯尔莫哥洛夫-阿恩斯德网络的可解释单细胞分析：用于细胞类型特异性基因发现和药物重定位
Haohuai He,Zhenchao Tang,Guanxing Chen et al.
Haohuai He et al.
Background: Analysis of single-cell RNA sequencing (scRNA-seq) data has revolutionized our understanding of cellular heterogeneity, yet current approaches face challenges in efficiency, interpretability, and connecting mo...
Hanwen Zhou,Yue Hu,Yulong Zheng et al.
Hanwen Zhou et al.
Background: RNA metabolism is tightly regulated by cis-elements and trans-acting factors. Most information guiding such regulation is encoded in RNA sequences. Deciphering the regulatory rules is critical for RNA biology ...
Fueling chromosomal gene diversification and artificial evolution with CRISPR [0.03%]
利用CRISPR促进染色体基因多样化和人工进化
Ruiying Zhu,Chuanhong Ren,Zehua Bao
Ruiying Zhu
Gene diversification is an effective approach to massively dissecting variant functions and evolving sequences when paired with an appropriate assay. In vitro mutagenesis and ectopic gene expression, however, fail to simulate the endogenous...
Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain [0.03%]
长读序技术揭示人脑中神经精神疾病易感基因的RNA异构体組合
Ricardo De Paoli-Iseppi,Shweta S Joshi,Josie Gleeson et al.
Ricardo De Paoli-Iseppi et al.
Background: Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes. Ho...
Identification of novel H2A histone variants across diverse clades of algae [0.03%]
藻类多样分类单元中新型H2A组蛋白变体的鉴定
Ellyn Rousselot,Zofia Nehr,Jean-Marc Aury et al.
Ellyn Rousselot et al.
Background: Histones are among the most conserved proteins in eukaryotes. They not only ensure DNA compaction in the nucleus but also participate in epigenetic regulation of gene expression. These key epigenetic players a...